Photodynamic therapy in lung and gastrointestinal cancers
Twelve central bronchial carcinoma patients and two gastrointestinal (GI) tract (oesophageal and colonic) early-stage cancer patients were treated with photodynamic therapy (PDT). Haematoporphyrin (HP/5, Jacopo Monico, Italy) at a dose of 5 mg kg −1 body weight was used as photosensitizer. Laser lig...
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| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 1990-06, Vol.6 (1), p.175-181 |
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| container_title | Journal of photochemistry and photobiology. B, Biology |
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| creator | Karanov, Strashimir Kostadinov, Dimitar Shopova, Maria Kurtev, Panayot |
| description | Twelve central bronchial carcinoma patients and two gastrointestinal (GI) tract (oesophageal and colonic) early-stage cancer patients were treated with photodynamic therapy (PDT). Haematoporphyrin (HP/5, Jacopo Monico, Italy) at a dose of 5 mg kg
−1 body weight was used as photosensitizer. Laser light at 628.2–630 nm generated by two different laser systems (gold vapour laser (I.P. Optics, Sofia, Bulgaria) in lung cancer cases and an argon dye laser system (Spectra Physics, Mountain View, U.S.A.) in GI tract cancers) was used. Lung cancers were irradiated 48 h after drug administration and GI tract cancers were irradiated 72 h after infusion of the photosensitizer. Both tumour sites were treated with a total energy dose in the range 350–600 J cm
−2. Efficiency of PDT in lung cancer was evaluated by X-rays and endoscopic and functional respiratory tests for bronchial de-obstruction. Complete remission after PDT of GI tract cancers was considered to be tumour eradication (histologically and cytologically proved) and a tumour-free interval of at least 12 months. |
| doi_str_mv | 10.1016/1011-1344(90)85087-D |
| format | Article |
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−2. Efficiency of PDT in lung cancer was evaluated by X-rays and endoscopic and functional respiratory tests for bronchial de-obstruction. Complete remission after PDT of GI tract cancers was considered to be tumour eradication (histologically and cytologically proved) and a tumour-free interval of at least 12 months.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/1011-1344(90)85087-D</identifier><identifier>PMID: 2121932</identifier><identifier>CODEN: JPPBEG</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Carcinoma, Bronchogenic - drug therapy ; Carcinoma, Bronchogenic - pathology ; Chemotherapy ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - pathology ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - pathology ; Haematoporphyrin ; Hematoporphyrins - therapeutic use ; Humans ; laser ; Lasers ; lung ; Lung Neoplasms - drug therapy ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; oesophageal and colon cancers ; Pharmacology. Drug treatments ; Photochemotherapy ; photodynamic therapy</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 1990-06, Vol.6 (1), p.175-181</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-870925ac05d5b853354e62e5ab0bd50c02473fc2396410743b50734ab3fc86373</citedby><cites>FETCH-LOGICAL-c387t-870925ac05d5b853354e62e5ab0bd50c02473fc2396410743b50734ab3fc86373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1011-1344(90)85087-D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,3539,23913,23914,25123,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19745731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2121932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karanov, Strashimir</creatorcontrib><creatorcontrib>Kostadinov, Dimitar</creatorcontrib><creatorcontrib>Shopova, Maria</creatorcontrib><creatorcontrib>Kurtev, Panayot</creatorcontrib><title>Photodynamic therapy in lung and gastrointestinal cancers</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>Twelve central bronchial carcinoma patients and two gastrointestinal (GI) tract (oesophageal and colonic) early-stage cancer patients were treated with photodynamic therapy (PDT). Haematoporphyrin (HP/5, Jacopo Monico, Italy) at a dose of 5 mg kg
−1 body weight was used as photosensitizer. Laser light at 628.2–630 nm generated by two different laser systems (gold vapour laser (I.P. Optics, Sofia, Bulgaria) in lung cancer cases and an argon dye laser system (Spectra Physics, Mountain View, U.S.A.) in GI tract cancers) was used. Lung cancers were irradiated 48 h after drug administration and GI tract cancers were irradiated 72 h after infusion of the photosensitizer. Both tumour sites were treated with a total energy dose in the range 350–600 J cm
−2. Efficiency of PDT in lung cancer was evaluated by X-rays and endoscopic and functional respiratory tests for bronchial de-obstruction. Complete remission after PDT of GI tract cancers was considered to be tumour eradication (histologically and cytologically proved) and a tumour-free interval of at least 12 months.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Bronchogenic - drug therapy</subject><subject>Carcinoma, Bronchogenic - pathology</subject><subject>Chemotherapy</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - pathology</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Haematoporphyrin</subject><subject>Hematoporphyrins - therapeutic use</subject><subject>Humans</subject><subject>laser</subject><subject>Lasers</subject><subject>lung</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>oesophageal and colon cancers</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemotherapy</subject><subject>photodynamic therapy</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoq67-A4VeFD1U89mkF0F2_YIFPeg5pGm6G2nTNWmF_fembtWbOUzCzDtvZh4AThC8QhBl1zGgFBFKL3J4KRgUPJ3vgAMkOElxJvBufP9I9sFhCO8wHpbxCZhghFFO8AHIX1Zt15Ybpxqrk25lvFpvEuuSunfLRLkyWarQ-da6zoTOOlUnWjltfDgCe5Wqgzke7yl4u797nT2mi-eHp9ntItVE8C4VHOaYKQ1ZyQrBCGHUZNgwVcCiZFBDTDmpNCZ5RhHklBQMckJVEZMiI5xMwfnWd-3bjz4OIRsbtKlr5UzbBykgjDqBopBuhdq3IXhTybW3jfIbiaAciA0ByQGHzKH8Jibnse109O-LxpS_TSOiWD8b6ypoVVc-rm_Dn3fOKeNk-P5mqzMRxqc1XgZtTURVWm90J8vW_j_IF0oqhZg</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Karanov, Strashimir</creator><creator>Kostadinov, Dimitar</creator><creator>Shopova, Maria</creator><creator>Kurtev, Panayot</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>Photodynamic therapy in lung and gastrointestinal cancers</title><author>Karanov, Strashimir ; Kostadinov, Dimitar ; Shopova, Maria ; Kurtev, Panayot</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-870925ac05d5b853354e62e5ab0bd50c02473fc2396410743b50734ab3fc86373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Bronchogenic - drug therapy</topic><topic>Carcinoma, Bronchogenic - pathology</topic><topic>Chemotherapy</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - pathology</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Haematoporphyrin</topic><topic>Hematoporphyrins - therapeutic use</topic><topic>Humans</topic><topic>laser</topic><topic>Lasers</topic><topic>lung</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>oesophageal and colon cancers</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemotherapy</topic><topic>photodynamic therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karanov, Strashimir</creatorcontrib><creatorcontrib>Kostadinov, Dimitar</creatorcontrib><creatorcontrib>Shopova, Maria</creatorcontrib><creatorcontrib>Kurtev, Panayot</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karanov, Strashimir</au><au>Kostadinov, Dimitar</au><au>Shopova, Maria</au><au>Kurtev, Panayot</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy in lung and gastrointestinal cancers</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>6</volume><issue>1</issue><spage>175</spage><epage>181</epage><pages>175-181</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><coden>JPPBEG</coden><abstract>Twelve central bronchial carcinoma patients and two gastrointestinal (GI) tract (oesophageal and colonic) early-stage cancer patients were treated with photodynamic therapy (PDT). Haematoporphyrin (HP/5, Jacopo Monico, Italy) at a dose of 5 mg kg
−1 body weight was used as photosensitizer. Laser light at 628.2–630 nm generated by two different laser systems (gold vapour laser (I.P. Optics, Sofia, Bulgaria) in lung cancer cases and an argon dye laser system (Spectra Physics, Mountain View, U.S.A.) in GI tract cancers) was used. Lung cancers were irradiated 48 h after drug administration and GI tract cancers were irradiated 72 h after infusion of the photosensitizer. Both tumour sites were treated with a total energy dose in the range 350–600 J cm
−2. Efficiency of PDT in lung cancer was evaluated by X-rays and endoscopic and functional respiratory tests for bronchial de-obstruction. Complete remission after PDT of GI tract cancers was considered to be tumour eradication (histologically and cytologically proved) and a tumour-free interval of at least 12 months.</abstract><cop>Lausanne</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2121932</pmid><doi>10.1016/1011-1344(90)85087-D</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of photochemistry and photobiology. B, Biology, 1990-06, Vol.6 (1), p.175-181 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Bronchogenic - drug therapy Carcinoma, Bronchogenic - pathology Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Esophageal Neoplasms - drug therapy Esophageal Neoplasms - pathology Haematoporphyrin Hematoporphyrins - therapeutic use Humans laser Lasers lung Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging oesophageal and colon cancers Pharmacology. Drug treatments Photochemotherapy photodynamic therapy |
| title | Photodynamic therapy in lung and gastrointestinal cancers |
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