Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells

The chemokine-CXCL12 and its receptor, CXCR4, have recently been shown to play an important role in regulating the directional migration of breast cancer cells to sites of metastasis. In the present study, we showed that CXCL12 enhanced the chemotaxis, chemoinvasion and adhesive properties of breast...

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Veröffentlicht in:	Oncogene 2004-01, Vol.23 (1), p.157-167
Hauptverfasser:	Fernandis, Aaron Zefrin, Prasad, Anil, Band, Hamid, Klösel, Roland, Ganju, Ramesh Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - pathology Cell Adhesion Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemokine CXCL12 Chemokines, CXC - pharmacology Chemotaxis Female Focal Adhesion Kinase 1 Focal Adhesion Kinase 2 Focal Adhesion Protein-Tyrosine Kinases Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Intracellular Signaling Peptides and Proteins Mammary gland diseases Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medical sciences Medicine Medicine & Public Health Mitogen-Activated Protein Kinases - physiology Molecular and cellular biology Neoplasm Invasiveness Neoplasm Metastasis Oncology original-paper Phosphatidylinositol 3-Kinases - physiology Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - physiology Protein-Tyrosine Kinases - metabolism Receptors, CXCR4 - physiology Tumors Tyrosine - metabolism
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