Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands

To analyze the role of Toll-like receptors (TLR) in the pathogenesis of rheumatoid arthritis, we have assessed the effects of stimulation of cultured synovial fibroblasts by the TLR-2 ligand bacterial peptidoglycan. By using high density oligonucleotide microarray analysis we identified 74 genes tha...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-01, Vol.172 (2), p.1256-1265
Hauptverfasser:	Pierer, Matthias, Rethage, Janine, Seibl, Reinhart, Lauener, Roger, Brentano, Fabia, Wagner, Ulf, Hantzschel, Holm, Michel, Beat A, Gay, Renate E, Gay, Steffen, Kyburz, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - microbiology Cells, Cultured Chemokine CCL5 - biosynthesis Chemokine CCL5 - metabolism Chemokine CCL8 Chemokine CXCL6 Chemokines - metabolism Chemokines, CXC - biosynthesis Chemokines, CXC - metabolism Chemotaxis, Leukocyte - immunology DNA microarrays Fibroblasts - immunology Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Profiling Humans Ligands Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Middle Aged Monocyte Chemoattractant Proteins - biosynthesis Monocyte Chemoattractant Proteins - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Oligonucleotide Array Sequence Analysis Osteoarthritis - immunology Osteoarthritis - metabolism Peptidoglycan - pharmacology Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Synovial Fluid - immunology Synovial Fluid - metabolism Synovial Membrane - immunology Synovial Membrane - metabolism Synovial Membrane - pathology TLR2 protein Toll-Like Receptor 2 Toll-Like Receptors Up-Regulation - immunology
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