Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion

The objective of this research project was to determine the physicochemical properties and investigate the drug release mechanism from ethyl cellulose (EC) matrix tablets prepared by either direct compression or hot-melt extrusion (HME) of binary mixtures of water soluble drug (guaifenesin) and the...

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Veröffentlicht in:	International journal of pharmaceutics 2004-01, Vol.269 (2), p.509-522
Hauptverfasser:	Crowley, Michael M., Schroeder, Britta, Fredersdorf, Anke, Obara, Sakae, Talarico, Mark, Kucera, Shawn, McGinity, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cellulose - analogs & derivatives Chemical Phenomena Chemistry, Pharmaceutical - methods Chemistry, Physical Delayed-Action Preparations Ethyl cellulose Expectorants Free volume General pharmacology Guaifenesin Higuchi diffusion model Hot-melt extrusion Kinetics Matrix tablets Medical sciences Mercury porosimetry Particle Size Percolation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Sclerosing Solutions Sustained release Tablets Technology, Pharmaceutical - methods Tortuosity
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