Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences
A pulsed magnetic field gradient spin echo technique was used to study the brain of two volunteers and eight patients. The pulsed gradients were applied both perpendicular and parallel to the image slice. Striking changes in signal intensity were demonstrated in white matter depending on the directi...
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| Veröffentlicht in: | Journal of computer assisted tomography 1990-11, Vol.14 (6), p.865-873 |
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| container_end_page | 873 |
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| container_issue | 6 |
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| container_title | Journal of computer assisted tomography |
| container_volume | 14 |
| creator | DORAN, M HAJNAL, J. V VAN BRUGGEN, N KING, M. D YOUNG, I. R BYDDER, G. M |
| description | A pulsed magnetic field gradient spin echo technique was used to study the brain of two volunteers and eight patients. The pulsed gradients were applied both perpendicular and parallel to the image slice. Striking changes in signal intensity were demonstrated in white matter depending on the direction in which pulsed gradients were applied. These effects enabled specific white matter tracts to be identified depending on the direction of their fibres. Abnormalities were also demonstrated in these tracts in patients with a variety of diseases, including cases where only minor abnormalities were seen with conventional, highly T2-weighted sequences. The effects were attributed to anisotropically restricted diffusion within white matter. The technique may have application in a wide range of neurological disease and result in better localisation of lesions and improved detection of disease. |
| doi_str_mv | 10.1097/00004728-199011000-00001 |
| format | Article |
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Abnormalities were also demonstrated in these tracts in patients with a variety of diseases, including cases where only minor abnormalities were seen with conventional, highly T2-weighted sequences. The effects were attributed to anisotropically restricted diffusion within white matter. The technique may have application in a wide range of neurological disease and result in better localisation of lesions and improved detection of disease.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS Dementia Complex - diagnosis</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - parasitology</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Intracranial Arteriovenous Malformations - diagnosis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiodiagnosis. Nmr imagery. 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V</au><au>VAN BRUGGEN, N</au><au>KING, M. D</au><au>YOUNG, I. R</au><au>BYDDER, G. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences</atitle><jtitle>Journal of computer assisted tomography</jtitle><addtitle>J Comput Assist Tomogr</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>14</volume><issue>6</issue><spage>865</spage><epage>873</epage><pages>865-873</pages><issn>0363-8715</issn><eissn>1532-3145</eissn><coden>JCATD5</coden><abstract>A pulsed magnetic field gradient spin echo technique was used to study the brain of two volunteers and eight patients. The pulsed gradients were applied both perpendicular and parallel to the image slice. Striking changes in signal intensity were demonstrated in white matter depending on the direction in which pulsed gradients were applied. These effects enabled specific white matter tracts to be identified depending on the direction of their fibres. Abnormalities were also demonstrated in these tracts in patients with a variety of diseases, including cases where only minor abnormalities were seen with conventional, highly T2-weighted sequences. The effects were attributed to anisotropically restricted diffusion within white matter. The technique may have application in a wide range of neurological disease and result in better localisation of lesions and improved detection of disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>2229559</pmid><doi>10.1097/00004728-199011000-00001</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0363-8715 |
| ispartof | Journal of computer assisted tomography, 1990-11, Vol.14 (6), p.865-873 |
| issn | 0363-8715 1532-3145 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acquired Immunodeficiency Syndrome - complications Adult AIDS Dementia Complex - diagnosis AIDS/HIV Biological and medical sciences Brain - pathology Brain Diseases - diagnosis Brain Diseases - parasitology Brain Neoplasms - diagnosis Female Humans Infant Intracranial Arteriovenous Malformations - diagnosis Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Radiodiagnosis. Nmr imagery. Nmr spectrometry Toxoplasmosis - complications Toxoplasmosis - diagnosis |
| title | Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences |
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