Chronic infusion of bradykinin delays the progression of heart failure and preserves vascular endothelium-mediated vasodilation in conscious dogs
This study examined the effects of chronic bradykinin infusion on hemodynamics and myocardial and endothelial functions during the development of heart failure. Sixteen instrumented dogs were randomized to receive through the left atria either vehicle or bradykinin (1 microg/min) during ventricular...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2004-01, Vol.109 (1), p.114-119 |
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| creator | TONDUANGU, Daniel HITTINGER, Luc JIN BO SU GHALEH, Bijan LE CORVOISIER, Philippe SAMBIN, Lucien CHAMPAGNE, Stéphane BADOUAL, Thierry VINCENT, Fanny BERDEAUX, Alain CROZATIER, Bertrand |
| description | This study examined the effects of chronic bradykinin infusion on hemodynamics and myocardial and endothelial functions during the development of heart failure.
Sixteen instrumented dogs were randomized to receive through the left atria either vehicle or bradykinin (1 microg/min) during ventricular pacing (250 bpm, 5 weeks). Hemodynamic and left ventricular (LV) parameters and the vasodilator responses to intravenous acetylcholine (0.3 to 3 microg/kg) and nitroglycerin (1 to 10 microg/kg) were examined in the control and after 3 and 5 weeks of pacing. The expression of endothelial NOS in femoral, carotid, and renal arteries was determined by Western blot analysis. After 3 weeks of pacing, changes in LV diastolic and systolic parameters were significantly lower in bradykinin-treated than vehicle-treated dogs (LV end-diastolic pressure, +10+/-3 versus +19+/-2 mm Hg; time constant of LV isovolumic relaxation, +11+/-2 versus +17+/-1 ms; LV wall thickening, -33+/-18% versus -75+/-9%; and cardiac output, -16+/-6% versus -32+/-6%; all P |
| doi_str_mv | 10.1161/01.CIR.0000105726.89770.35 |
| format | Article |
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Sixteen instrumented dogs were randomized to receive through the left atria either vehicle or bradykinin (1 microg/min) during ventricular pacing (250 bpm, 5 weeks). Hemodynamic and left ventricular (LV) parameters and the vasodilator responses to intravenous acetylcholine (0.3 to 3 microg/kg) and nitroglycerin (1 to 10 microg/kg) were examined in the control and after 3 and 5 weeks of pacing. The expression of endothelial NOS in femoral, carotid, and renal arteries was determined by Western blot analysis. After 3 weeks of pacing, changes in LV diastolic and systolic parameters were significantly lower in bradykinin-treated than vehicle-treated dogs (LV end-diastolic pressure, +10+/-3 versus +19+/-2 mm Hg; time constant of LV isovolumic relaxation, +11+/-2 versus +17+/-1 ms; LV wall thickening, -33+/-18% versus -75+/-9%; and cardiac output, -16+/-6% versus -32+/-6%; all P<0.05). Compared with vehicle-treated dogs, bradykinin-treated dogs had a reduced rightward shift of the diastolic LV pressure-diameter relation and a reduced diastolic LV wall stress. Similar trends were observed after 5 weeks. The vasodilator response to nitroglycerin was preserved in both groups. The response to acetylcholine was blunted in vehicle-treated but preserved in bradykinin-treated dogs. Vascular endothelial NOS expression decreased in vehicle-treated but was preserved in bradykinin-treated dogs.
In conscious dogs, chronic bradykinin infusion delays the heart failure progression by preserving LV diastolic and systolic functions and by preserving vascular endothelial function.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000105726.89770.35</identifier><identifier>PMID: 14662711</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acetylcholine - pharmacology ; Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Blotting, Western ; Bradykinin - pharmacology ; Bradykinin - therapeutic use ; Cardiac Output - drug effects ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Dogs ; Endothelium, Vascular - enzymology ; Endothelium, Vascular - physiopathology ; Heart Failure - drug therapy ; Heart Failure - pathology ; Heart Failure - physiopathology ; Heart Ventricles - drug effects ; Heart Ventricles - pathology ; Medical sciences ; Myocardial Contraction - drug effects ; Nitric Oxide Synthase - biosynthesis ; Nitric Oxide Synthase Type III ; Nitroglycerin - pharmacology ; Vasodilation - drug effects ; Ventricular Pressure - drug effects</subject><ispartof>Circulation (New York, N.Y.), 2004-01, Vol.109 (1), p.114-119</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 6 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-4334b8ce423286e1eb72037a124ceb15b56407c6c459c43f334db8a794ddfc4c3</citedby><cites>FETCH-LOGICAL-c465t-4334b8ce423286e1eb72037a124ceb15b56407c6c459c43f334db8a794ddfc4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15599257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14662711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TONDUANGU, Daniel</creatorcontrib><creatorcontrib>HITTINGER, Luc</creatorcontrib><creatorcontrib>JIN BO SU</creatorcontrib><creatorcontrib>GHALEH, Bijan</creatorcontrib><creatorcontrib>LE CORVOISIER, Philippe</creatorcontrib><creatorcontrib>SAMBIN, Lucien</creatorcontrib><creatorcontrib>CHAMPAGNE, Stéphane</creatorcontrib><creatorcontrib>BADOUAL, Thierry</creatorcontrib><creatorcontrib>VINCENT, Fanny</creatorcontrib><creatorcontrib>BERDEAUX, Alain</creatorcontrib><creatorcontrib>CROZATIER, Bertrand</creatorcontrib><title>Chronic infusion of bradykinin delays the progression of heart failure and preserves vascular endothelium-mediated vasodilation in conscious dogs</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>This study examined the effects of chronic bradykinin infusion on hemodynamics and myocardial and endothelial functions during the development of heart failure.
Sixteen instrumented dogs were randomized to receive through the left atria either vehicle or bradykinin (1 microg/min) during ventricular pacing (250 bpm, 5 weeks). Hemodynamic and left ventricular (LV) parameters and the vasodilator responses to intravenous acetylcholine (0.3 to 3 microg/kg) and nitroglycerin (1 to 10 microg/kg) were examined in the control and after 3 and 5 weeks of pacing. The expression of endothelial NOS in femoral, carotid, and renal arteries was determined by Western blot analysis. After 3 weeks of pacing, changes in LV diastolic and systolic parameters were significantly lower in bradykinin-treated than vehicle-treated dogs (LV end-diastolic pressure, +10+/-3 versus +19+/-2 mm Hg; time constant of LV isovolumic relaxation, +11+/-2 versus +17+/-1 ms; LV wall thickening, -33+/-18% versus -75+/-9%; and cardiac output, -16+/-6% versus -32+/-6%; all P<0.05). Compared with vehicle-treated dogs, bradykinin-treated dogs had a reduced rightward shift of the diastolic LV pressure-diameter relation and a reduced diastolic LV wall stress. Similar trends were observed after 5 weeks. The vasodilator response to nitroglycerin was preserved in both groups. The response to acetylcholine was blunted in vehicle-treated but preserved in bradykinin-treated dogs. Vascular endothelial NOS expression decreased in vehicle-treated but was preserved in bradykinin-treated dogs.
In conscious dogs, chronic bradykinin infusion delays the heart failure progression by preserving LV diastolic and systolic functions and by preserving vascular endothelial function.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blotting, Western</subject><subject>Bradykinin - pharmacology</subject><subject>Bradykinin - therapeutic use</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Dogs</subject><subject>Endothelium, Vascular - enzymology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - pathology</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Nitroglycerin - pharmacology</subject><subject>Vasodilation - drug effects</subject><subject>Ventricular Pressure - drug effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkduKFDEQhoMo7rj6ChIW9K7bnNPtnQweFhYE0euQTqp3smaSNelemMfwjc24IwPWTSjq-6sq9SN0RUlPqaLvCO2319960oISqZnqh1Fr0nP5BG2oZKITko9P0aYBY6c5YxfoRa13LVVcy-foggqlmKZ0g35vdyWn4HBI81pDTjjPeCrWH36GFBL2EO2h4mUH-L7k2wL1H7QDWxY82xDXAtgm3wCoUB6g4gdb3RptwZB8btoY1n23Bx_sAv5YzT5Euxw7tRkup-pCXiv2-ba-RM9mGyu8Or2X6Menj9-3X7qbr5-vtx9uOieUXDrBuZgGB4JxNiigMGlGuLaUCQcTlZNUgminnJCjE3xuuJ8Gq0fh_eyE45fo7WPf9q9fK9TF7EN1EKNN0HYxAyEDp5I38Oo_8C6vJbXdDKNMSzJo1aD3j5ArudYCs7kvYW_LwVBijq4ZQk1zzZxdM39dM1w28evThHVqVzpLTzY14M0JaIe1cS42uVDPnJTjyKTmfwDIuKNd</recordid><startdate>20040106</startdate><enddate>20040106</enddate><creator>TONDUANGU, Daniel</creator><creator>HITTINGER, Luc</creator><creator>JIN BO SU</creator><creator>GHALEH, Bijan</creator><creator>LE CORVOISIER, Philippe</creator><creator>SAMBIN, Lucien</creator><creator>CHAMPAGNE, Stéphane</creator><creator>BADOUAL, Thierry</creator><creator>VINCENT, Fanny</creator><creator>BERDEAUX, Alain</creator><creator>CROZATIER, Bertrand</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20040106</creationdate><title>Chronic infusion of bradykinin delays the progression of heart failure and preserves vascular endothelium-mediated vasodilation in conscious dogs</title><author>TONDUANGU, Daniel ; HITTINGER, Luc ; JIN BO SU ; GHALEH, Bijan ; LE CORVOISIER, Philippe ; SAMBIN, Lucien ; CHAMPAGNE, Stéphane ; BADOUAL, Thierry ; VINCENT, Fanny ; BERDEAUX, Alain ; CROZATIER, Bertrand</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-4334b8ce423286e1eb72037a124ceb15b56407c6c459c43f334db8a794ddfc4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blotting, Western</topic><topic>Bradykinin - pharmacology</topic><topic>Bradykinin - therapeutic use</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Dogs</topic><topic>Endothelium, Vascular - enzymology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - pathology</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Nitroglycerin - pharmacology</topic><topic>Vasodilation - drug effects</topic><topic>Ventricular Pressure - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TONDUANGU, Daniel</creatorcontrib><creatorcontrib>HITTINGER, Luc</creatorcontrib><creatorcontrib>JIN BO SU</creatorcontrib><creatorcontrib>GHALEH, Bijan</creatorcontrib><creatorcontrib>LE CORVOISIER, Philippe</creatorcontrib><creatorcontrib>SAMBIN, Lucien</creatorcontrib><creatorcontrib>CHAMPAGNE, Stéphane</creatorcontrib><creatorcontrib>BADOUAL, Thierry</creatorcontrib><creatorcontrib>VINCENT, Fanny</creatorcontrib><creatorcontrib>BERDEAUX, Alain</creatorcontrib><creatorcontrib>CROZATIER, Bertrand</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TONDUANGU, Daniel</au><au>HITTINGER, Luc</au><au>JIN BO SU</au><au>GHALEH, Bijan</au><au>LE CORVOISIER, Philippe</au><au>SAMBIN, Lucien</au><au>CHAMPAGNE, Stéphane</au><au>BADOUAL, Thierry</au><au>VINCENT, Fanny</au><au>BERDEAUX, Alain</au><au>CROZATIER, Bertrand</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic infusion of bradykinin delays the progression of heart failure and preserves vascular endothelium-mediated vasodilation in conscious dogs</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2004-01-06</date><risdate>2004</risdate><volume>109</volume><issue>1</issue><spage>114</spage><epage>119</epage><pages>114-119</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>This study examined the effects of chronic bradykinin infusion on hemodynamics and myocardial and endothelial functions during the development of heart failure.
Sixteen instrumented dogs were randomized to receive through the left atria either vehicle or bradykinin (1 microg/min) during ventricular pacing (250 bpm, 5 weeks). Hemodynamic and left ventricular (LV) parameters and the vasodilator responses to intravenous acetylcholine (0.3 to 3 microg/kg) and nitroglycerin (1 to 10 microg/kg) were examined in the control and after 3 and 5 weeks of pacing. The expression of endothelial NOS in femoral, carotid, and renal arteries was determined by Western blot analysis. After 3 weeks of pacing, changes in LV diastolic and systolic parameters were significantly lower in bradykinin-treated than vehicle-treated dogs (LV end-diastolic pressure, +10+/-3 versus +19+/-2 mm Hg; time constant of LV isovolumic relaxation, +11+/-2 versus +17+/-1 ms; LV wall thickening, -33+/-18% versus -75+/-9%; and cardiac output, -16+/-6% versus -32+/-6%; all P<0.05). Compared with vehicle-treated dogs, bradykinin-treated dogs had a reduced rightward shift of the diastolic LV pressure-diameter relation and a reduced diastolic LV wall stress. Similar trends were observed after 5 weeks. The vasodilator response to nitroglycerin was preserved in both groups. The response to acetylcholine was blunted in vehicle-treated but preserved in bradykinin-treated dogs. Vascular endothelial NOS expression decreased in vehicle-treated but was preserved in bradykinin-treated dogs.
In conscious dogs, chronic bradykinin infusion delays the heart failure progression by preserving LV diastolic and systolic functions and by preserving vascular endothelial function.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14662711</pmid><doi>10.1161/01.CIR.0000105726.89770.35</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2004-01, Vol.109 (1), p.114-119 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetylcholine - pharmacology Animals Biological and medical sciences Blood and lymphatic vessels Blotting, Western Bradykinin - pharmacology Bradykinin - therapeutic use Cardiac Output - drug effects Cardiac Pacing, Artificial Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dogs Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology Heart Failure - drug therapy Heart Failure - pathology Heart Failure - physiopathology Heart Ventricles - drug effects Heart Ventricles - pathology Medical sciences Myocardial Contraction - drug effects Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type III Nitroglycerin - pharmacology Vasodilation - drug effects Ventricular Pressure - drug effects |
| title | Chronic infusion of bradykinin delays the progression of heart failure and preserves vascular endothelium-mediated vasodilation in conscious dogs |
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