Intestinal mucosal mast cells in Nippostrongylus-infected mice: Lack of sensitivity to corticosteroids
Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion...
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| Veröffentlicht in: | International journal for parasitology 1990-08, Vol.20 (5), p.669-672 |
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| container_end_page | 672 |
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| container_title | International journal for parasitology |
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| creator | Newlands, G.F.J. MacKellar, Anne Miller, H.R.P. |
| description | Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion in mice with corticosteroids. We have therefore examined the effects of corticosteroids on mast cell numbers and concentrations of the mast cell granule-specific serine protease Mouse Intestinal Mast Cell Protease (MIMCP) in the intestines of mice infected with
Nippostrongylus brasiliensis. Mucosal mast cell (MMC) numbers and concentrations of MIMCP were unaltered by steroid treatment. This is in marked contrast to
Nippostrongylus-infected rats which showed decreases in both mast cell numbers and concentrations of the rat mucosal mast cell protease RMCP II after steroid treatment. This suggests that differentiated murine MMC are less dependent on T cells than those of the rat. |
| doi_str_mv | 10.1016/0020-7519(90)90125-7 |
| format | Article |
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Nippostrongylus brasiliensis. Mucosal mast cell (MMC) numbers and concentrations of MIMCP were unaltered by steroid treatment. This is in marked contrast to
Nippostrongylus-infected rats which showed decreases in both mast cell numbers and concentrations of the rat mucosal mast cell protease RMCP II after steroid treatment. This suggests that differentiated murine MMC are less dependent on T cells than those of the rat.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/0020-7519(90)90125-7</identifier><identifier>PMID: 2228427</identifier><identifier>CODEN: IJPYBT</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell Count ; corticosteroids ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; intestine ; Intestines - immunology ; Mast Cells - drug effects ; Mice ; mouse ; Mucosal mast cells ; Nematode Infections - immunology ; Nippostrongylus - immunology ; Nippostrongylus brasiliensis ; Prednisolone - pharmacology ; rat ; Rats ; Rats, Inbred Strains</subject><ispartof>International journal for parasitology, 1990-08, Vol.20 (5), p.669-672</ispartof><rights>1990</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-74ce1ba317fb1c5bf9fa229e78c7b9a40c79e1dc20f9b55dc224e5e1dc1c13dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0020-7519(90)90125-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5135636$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2228427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newlands, G.F.J.</creatorcontrib><creatorcontrib>MacKellar, Anne</creatorcontrib><creatorcontrib>Miller, H.R.P.</creatorcontrib><title>Intestinal mucosal mast cells in Nippostrongylus-infected mice: Lack of sensitivity to corticosteroids</title><title>International journal for parasitology</title><addtitle>Int J Parasitol</addtitle><description>Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion in mice with corticosteroids. We have therefore examined the effects of corticosteroids on mast cell numbers and concentrations of the mast cell granule-specific serine protease Mouse Intestinal Mast Cell Protease (MIMCP) in the intestines of mice infected with
Nippostrongylus brasiliensis. Mucosal mast cell (MMC) numbers and concentrations of MIMCP were unaltered by steroid treatment. This is in marked contrast to
Nippostrongylus-infected rats which showed decreases in both mast cell numbers and concentrations of the rat mucosal mast cell protease RMCP II after steroid treatment. This suggests that differentiated murine MMC are less dependent on T cells than those of the rat.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>corticosteroids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>intestine</subject><subject>Intestines - immunology</subject><subject>Mast Cells - drug effects</subject><subject>Mice</subject><subject>mouse</subject><subject>Mucosal mast cells</subject><subject>Nematode Infections - immunology</subject><subject>Nippostrongylus - immunology</subject><subject>Nippostrongylus brasiliensis</subject><subject>Prednisolone - pharmacology</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-r1TAQxYMoz-vTb6CQhYguqpm0aRoXgjz88-CiG12HNJ1ItG2umfTB_fa23std6mpC5pczmXMYewriNQho3wghRaUVmJdGvDICpKr0PbaDTptKQK3us90FecgeEf0UAlTdNFfsSkrZNVLvWLidC1KJsxv5tPhEW3VUuMdxJB5n_iUeDolKTvOP47hQFeeAvuDAp-jxLd87_4unwAlniiXexXLkJXGfcomrXMGc4kCP2YPgRsIn53rNvn_88O3mc7X_-un25v2-8nXblko3HqF3NejQg1d9MMFJaVB3XvfGNcJrgzB4KYLplVoPskG13YCHehjqa_bipHvI6feyLmanSNsqbsa0kO2E6GTb6f-CoHQHYNoVbE6gz4koY7CHHCeXjxaE3XKwm8l2M9kaYf_mYDf9Z2f9pZ9wuDw6G7_2n5_7jrwbQ3azj3TB1JpfW2_T350wXE27i5gt-YizxyHmNQU7pPjvf_wBzHmmHQ</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Newlands, G.F.J.</creator><creator>MacKellar, Anne</creator><creator>Miller, H.R.P.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900801</creationdate><title>Intestinal mucosal mast cells in Nippostrongylus-infected mice: Lack of sensitivity to corticosteroids</title><author>Newlands, G.F.J. ; MacKellar, Anne ; Miller, H.R.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-74ce1ba317fb1c5bf9fa229e78c7b9a40c79e1dc20f9b55dc224e5e1dc1c13dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>corticosteroids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>intestine</topic><topic>Intestines - immunology</topic><topic>Mast Cells - drug effects</topic><topic>Mice</topic><topic>mouse</topic><topic>Mucosal mast cells</topic><topic>Nematode Infections - immunology</topic><topic>Nippostrongylus - immunology</topic><topic>Nippostrongylus brasiliensis</topic><topic>Prednisolone - pharmacology</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newlands, G.F.J.</creatorcontrib><creatorcontrib>MacKellar, Anne</creatorcontrib><creatorcontrib>Miller, H.R.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newlands, G.F.J.</au><au>MacKellar, Anne</au><au>Miller, H.R.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal mucosal mast cells in Nippostrongylus-infected mice: Lack of sensitivity to corticosteroids</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>20</volume><issue>5</issue><spage>669</spage><epage>672</epage><pages>669-672</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><coden>IJPYBT</coden><abstract>Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion in mice with corticosteroids. We have therefore examined the effects of corticosteroids on mast cell numbers and concentrations of the mast cell granule-specific serine protease Mouse Intestinal Mast Cell Protease (MIMCP) in the intestines of mice infected with
Nippostrongylus brasiliensis. Mucosal mast cell (MMC) numbers and concentrations of MIMCP were unaltered by steroid treatment. This is in marked contrast to
Nippostrongylus-infected rats which showed decreases in both mast cell numbers and concentrations of the rat mucosal mast cell protease RMCP II after steroid treatment. This suggests that differentiated murine MMC are less dependent on T cells than those of the rat.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2228427</pmid><doi>10.1016/0020-7519(90)90125-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Count corticosteroids Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects intestine Intestines - immunology Mast Cells - drug effects Mice mouse Mucosal mast cells Nematode Infections - immunology Nippostrongylus - immunology Nippostrongylus brasiliensis Prednisolone - pharmacology rat Rats Rats, Inbred Strains |
| title | Intestinal mucosal mast cells in Nippostrongylus-infected mice: Lack of sensitivity to corticosteroids |
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