Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa
Objective: Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplem...
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| Veröffentlicht in: | The International journal of eating disorders 2004-01, Vol.35 (1), p.10-15 |
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| container_title | The International journal of eating disorders |
| container_volume | 35 |
| creator | Barbarich, N.C McConaha, C.W Halmi, K.A Gendall, K Sunday, S.R Gaskill, J La Via, M Frank, G.K Brooks, S Plotnicov, K.H |
| description | Objective: Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects. Method: Twenty-six subjects with AN participated in a trial of fluoxetine. In a double-blind, placebo-controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function. Results: There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms. Discussion: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects. |
| doi_str_mv | 10.1002/eat.10235 |
| format | Article |
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However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects. Method: Twenty-six subjects with AN participated in a trial of fluoxetine. In a double-blind, placebo-controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function. Results: There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms. Discussion: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects.</description><identifier>ISSN: 0276-3478</identifier><identifier>EISSN: 1098-108X</identifier><identifier>DOI: 10.1002/eat.10235</identifier><identifier>PMID: 14705152</identifier><identifier>CODEN: INDIDJ</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Anorexia ; anorexia nervosa ; Anorexia Nervosa - drug therapy ; Anorexia Nervosa - therapy ; Biological and medical sciences ; clinical nutrition ; Combined Modality Therapy ; Dietary Supplements ; Docosahexaenoic Acids - therapeutic use ; Double-Blind Method ; drug therapy ; Eating disorders ; Eicosanoic Acids - therapeutic use ; Female ; Fish Oils - administration & dosage ; fluoxetine ; Fluoxetine - administration & dosage ; Fluoxetine - therapeutic use ; gaining weight ; Humans ; malnutrition ; Medical sciences ; Medical treatment ; Neuropharmacology ; nutrient intake ; Nutrition Therapy - methods ; nutritional adequacy ; nutritional intervention ; nutritional supplements ; patients ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - therapeutic use ; Tryptophan - therapeutic use ; Vitamins - therapeutic use</subject><ispartof>The International journal of eating disorders, 2004-01, Vol.35 (1), p.10-15</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 by Wiley Periodicals, Inc. Int J Eat Disord 35: 10-15, 2004.</rights><rights>Copyright Wiley Periodicals Inc. 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J. Eat. Disord</addtitle><description>Objective: Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects. Method: Twenty-six subjects with AN participated in a trial of fluoxetine. In a double-blind, placebo-controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function. Results: There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms. Discussion: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects.</description><subject>Adult</subject><subject>Anorexia</subject><subject>anorexia nervosa</subject><subject>Anorexia Nervosa - drug therapy</subject><subject>Anorexia Nervosa - therapy</subject><subject>Biological and medical sciences</subject><subject>clinical nutrition</subject><subject>Combined Modality Therapy</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Double-Blind Method</subject><subject>drug therapy</subject><subject>Eating disorders</subject><subject>Eicosanoic Acids - therapeutic use</subject><subject>Female</subject><subject>Fish Oils - administration & dosage</subject><subject>fluoxetine</subject><subject>Fluoxetine - administration & dosage</subject><subject>Fluoxetine - therapeutic use</subject><subject>gaining weight</subject><subject>Humans</subject><subject>malnutrition</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Neuropharmacology</subject><subject>nutrient intake</subject><subject>Nutrition Therapy - methods</subject><subject>nutritional adequacy</subject><subject>nutritional intervention</subject><subject>nutritional supplements</subject><subject>patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Tryptophan - therapeutic use</subject><subject>Vitamins - therapeutic use</subject><issn>0276-3478</issn><issn>1098-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10N1vFCEQAHBiNPasPvgP6MZEEx_WDrDsx2Nzqa2xfiT2om-EpYNy7sEJrN7997Ld0yYmEhIg8xtghpDHFF5RAHaCKuUN4-IOWVDo2pJC--UuWQBr6pJXTXtEHsS4BoCag7hPjmjVgKCCLch6FbHwpnBjCjZZ79RQxHG7HXCDLsUi-cI6HVBllr5hgcZYrfR-yjHD6HeYrMNsbqIpwzQlTmHlfMCdVYXD8NNH9ZDcM2qI-OiwHpPV67Or5UV5-eH8zfL0stQCalEaoXt23QrK2oZxzKceKtOzSmHV9L3BXnOkzNSMN6rB2rRGQdexqtcdIOf8mLyY790G_2PEmOTGRo3DoBz6McoWoGWioxk--weu_RhyB6JkdBqcT-jljHTwMQY0chvsRoW9pCCn7stcsrzpfrZPDheO_Qavb-Wh3Rk8PwAVtRpMUE7beOtExbo8szuZ3S874P7_L8qz06s_T5dzho0Jd38zVPgu64Y3Qn5-fy4Fu3gHy7et_Jj909kb5aX6GvIvVp8YUA7Q5bIp8N8RlrRY</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Barbarich, N.C</creator><creator>McConaha, C.W</creator><creator>Halmi, K.A</creator><creator>Gendall, K</creator><creator>Sunday, S.R</creator><creator>Gaskill, J</creator><creator>La Via, M</creator><creator>Frank, G.K</creator><creator>Brooks, S</creator><creator>Plotnicov, K.H</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa</title><author>Barbarich, N.C ; McConaha, C.W ; Halmi, K.A ; Gendall, K ; Sunday, S.R ; Gaskill, J ; La Via, M ; Frank, G.K ; Brooks, S ; Plotnicov, K.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5065-f5cb2d85128723e5cbb04fb24ae47bbfebc3e12f6237a7e6f8fa09924bc90e333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Anorexia</topic><topic>anorexia nervosa</topic><topic>Anorexia Nervosa - drug therapy</topic><topic>Anorexia Nervosa - therapy</topic><topic>Biological and medical sciences</topic><topic>clinical nutrition</topic><topic>Combined Modality Therapy</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic Acids - therapeutic use</topic><topic>Double-Blind Method</topic><topic>drug therapy</topic><topic>Eating disorders</topic><topic>Eicosanoic Acids - therapeutic use</topic><topic>Female</topic><topic>Fish Oils - administration & dosage</topic><topic>fluoxetine</topic><topic>Fluoxetine - administration & dosage</topic><topic>Fluoxetine - therapeutic use</topic><topic>gaining weight</topic><topic>Humans</topic><topic>malnutrition</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Neuropharmacology</topic><topic>nutrient intake</topic><topic>Nutrition Therapy - methods</topic><topic>nutritional adequacy</topic><topic>nutritional intervention</topic><topic>nutritional supplements</topic><topic>patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Tryptophan - therapeutic use</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbarich, N.C</creatorcontrib><creatorcontrib>McConaha, C.W</creatorcontrib><creatorcontrib>Halmi, K.A</creatorcontrib><creatorcontrib>Gendall, K</creatorcontrib><creatorcontrib>Sunday, S.R</creatorcontrib><creatorcontrib>Gaskill, J</creatorcontrib><creatorcontrib>La Via, M</creatorcontrib><creatorcontrib>Frank, G.K</creatorcontrib><creatorcontrib>Brooks, S</creatorcontrib><creatorcontrib>Plotnicov, K.H</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of eating disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbarich, N.C</au><au>McConaha, C.W</au><au>Halmi, K.A</au><au>Gendall, K</au><au>Sunday, S.R</au><au>Gaskill, J</au><au>La Via, M</au><au>Frank, G.K</au><au>Brooks, S</au><au>Plotnicov, K.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa</atitle><jtitle>The International journal of eating disorders</jtitle><addtitle>Int. J. Eat. Disord</addtitle><date>2004-01</date><risdate>2004</risdate><volume>35</volume><issue>1</issue><spage>10</spage><epage>15</epage><pages>10-15</pages><issn>0276-3478</issn><eissn>1098-108X</eissn><coden>INDIDJ</coden><abstract>Objective: Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects. Method: Twenty-six subjects with AN participated in a trial of fluoxetine. In a double-blind, placebo-controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function. Results: There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms. Discussion: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14705152</pmid><doi>10.1002/eat.10235</doi><tpages>6</tpages></addata></record> |
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| ispartof | The International journal of eating disorders, 2004-01, Vol.35 (1), p.10-15 |
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| subjects | Adult Anorexia anorexia nervosa Anorexia Nervosa - drug therapy Anorexia Nervosa - therapy Biological and medical sciences clinical nutrition Combined Modality Therapy Dietary Supplements Docosahexaenoic Acids - therapeutic use Double-Blind Method drug therapy Eating disorders Eicosanoic Acids - therapeutic use Female Fish Oils - administration & dosage fluoxetine Fluoxetine - administration & dosage Fluoxetine - therapeutic use gaining weight Humans malnutrition Medical sciences Medical treatment Neuropharmacology nutrient intake Nutrition Therapy - methods nutritional adequacy nutritional intervention nutritional supplements patients Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - therapeutic use Tryptophan - therapeutic use Vitamins - therapeutic use |
| title | Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa |
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