Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report

A common polymorphism in the catechol-O-methyltransferase gene involves a valine to methionine mutation that results in a threefold to fourfold decrease in enzyme activity. This polymorphism has been associated with altered μ-opioid receptor binding potential and prefrontal cognitive performance, as...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological psychiatry (1969) 2004, Vol.55 (1), p.102-105
Hauptverfasser:	Oswald, Lynn M, McCaul, Mary, Choi, Leena, Yang, Xioaju, Wand, Gary S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenocorticotropic Hormone - antagonists & inhibitors Adrenocorticotropic Hormone - metabolism adrenocorticotropin Adult Alleles Behavioral psychophysiology Biological and medical sciences Catechol O-Methyltransferase - genetics Catecholamine cortisol Female Fundamental and applied biological sciences. Psychology Gene Expression - genetics genetics Genotype Hormones and behavior human Humans Hydrocortisone - antagonists & inhibitors Hydrocortisone - metabolism hypertension Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Male Methionine - genetics naloxone Naloxone - pharmacology Narcotic Antagonists - pharmacology neuroendocrine Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!