The cyclic diguanylic acid regulatory system of cellulose synthesis in Acetobacter xylinum. Chemical synthesis and biological activity of cyclic nucleotide dimer, trimer, and phosphothioate derivatives

An unusual compound, cyclic-bis(3‘—-5‘) diguanylic acid (c-di-GMP or cGpGp), is involved in the regulation of cellulose synthesis in the bacterium Acetobacter xylinum. This cyclic dinucleotide acts as an allosteric, positive effector of cellulose synthase activity in vitro (Ka = 0.31 microM) and is...

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Veröffentlicht in:	The Journal of biological chemistry 1990-11, Vol.265 (31), p.18933-18943
Hauptverfasser:	Ross, P, Mayer, R, Weinhouse, H, Amikam, D, Huggirat, Y, Benziman, M, de Vroom, E, Fidder, A, de Paus, P, Sliedregt, L.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetobacter xylinum Allosteric Regulation Arabidopsis Proteins Calcium - pharmacology Cellulose - biosynthesis Cyclic GMP - analogs & derivatives Cyclic GMP - chemical synthesis Cyclic GMP - pharmacology Gluconacetobacter xylinus - metabolism Glucosyltransferases - metabolism Indicators and Reagents Structure-Activity Relationship Uridine Diphosphate Glucose - metabolism
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