Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine
We demonstrate that Mycobacterium tuberculosis that is unable to export the complex lipid phthiocerol dimycocerosate has a decreased capacity to replicate in mice and affords sustained protective immunity against M. tuberculosis infection Protection was significantly better than that provided by the...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-01, Vol.189 (1), p.105-112 |
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| container_title | The Journal of infectious diseases |
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| creator | Pinto, Rachel Saunders, Bernadette M. Camacho, Luis R. Britton, Warwick J. Gicquel, Brigitte Triccas, James A. |
| description | We demonstrate that Mycobacterium tuberculosis that is unable to export the complex lipid phthiocerol dimycocerosate has a decreased capacity to replicate in mice and affords sustained protective immunity against M. tuberculosis infection Protection was significantly better than that provided by the existing vaccine, Mycobacterium bovis bacille Calmette-Guérin (BCG), and this improved protective efficacy was maintained for at least 24 weeks after vaccination. Protection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-γ–secreting cells equal to that induced by virulent M. tuberculosis and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG. These results suggest that the BCG vaccine may be too attenuated to afford effective protective immunity against tuberculosis, and vaccine strains that can provide sustained delivery of mycobacterial antigens are promising antituberculosis vaccine candidates |
| doi_str_mv | 10.1086/380413 |
| format | Article |
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Protection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-γ–secreting cells equal to that induced by virulent M. tuberculosis and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG. These results suggest that the BCG vaccine may be too attenuated to afford effective protective immunity against tuberculosis, and vaccine strains that can provide sustained delivery of mycobacterial antigens are promising antituberculosis vaccine candidates</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/380413</identifier><identifier>PMID: 14702160</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Antigens ; Antigens, Bacterial - immunology ; Applied microbiology ; Bacteria ; Bacterial diseases ; Biological and medical sciences ; Disease Models, Animal ; Female ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Immunity ; Immunity, Cellular ; Infections ; Infectious diseases ; Interferon-gamma - biosynthesis ; Lesions ; Lipids - deficiency ; Lipids - genetics ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microbiology ; Mutation ; Mycobacterium bovis ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - enzymology ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - immunology ; Spleen ; Spleen - immunology ; Splenic tuberculosis ; T-Lymphocytes - immunology ; Transcriptional regulatory elements ; Translocation, Genetic ; Tuberculosis - immunology ; Tuberculosis - prevention & control ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis vaccine ; Tuberculosis Vaccines - administration & dosage ; Tuberculosis Vaccines - immunology ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - immunology</subject><ispartof>The Journal of infectious diseases, 2004-01, Vol.189 (1), p.105-112</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 1 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-1976d38c99283a51c59841df7716f56758fda1f24cb780bf2d64f25d44b9add33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075788$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075788$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,4024,27923,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15663011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14702160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto, Rachel</creatorcontrib><creatorcontrib>Saunders, Bernadette M.</creatorcontrib><creatorcontrib>Camacho, Luis R.</creatorcontrib><creatorcontrib>Britton, Warwick J.</creatorcontrib><creatorcontrib>Gicquel, Brigitte</creatorcontrib><creatorcontrib>Triccas, James A.</creatorcontrib><title>Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We demonstrate that Mycobacterium tuberculosis that is unable to export the complex lipid phthiocerol dimycocerosate has a decreased capacity to replicate in mice and affords sustained protective immunity against M. tuberculosis infection Protection was significantly better than that provided by the existing vaccine, Mycobacterium bovis bacille Calmette-Guérin (BCG), and this improved protective efficacy was maintained for at least 24 weeks after vaccination. Protection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-γ–secreting cells equal to that induced by virulent M. tuberculosis and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG. These results suggest that the BCG vaccine may be too attenuated to afford effective protective immunity against tuberculosis, and vaccine strains that can provide sustained delivery of mycobacterial antigens are promising antituberculosis vaccine candidates</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Immunity</subject><subject>Immunity, Cellular</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Lesions</subject><subject>Lipids - deficiency</subject><subject>Lipids - genetics</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - enzymology</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Spleen</subject><subject>Spleen - immunology</subject><subject>Splenic tuberculosis</subject><subject>T-Lymphocytes - immunology</subject><subject>Transcriptional regulatory elements</subject><subject>Translocation, Genetic</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis vaccine</subject><subject>Tuberculosis Vaccines - administration & dosage</subject><subject>Tuberculosis Vaccines - immunology</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9u0zAUxi0EYqXAG4AM0rgL2HHiP5fQjXaiwARlQtxYjuOsLknc2c60PhIPwRUvhqtWK0JC3PhY_n7-jo8_AB5j9BIjTl8RjgpM7oARLgnLKMXkLhghlOcZ5kIcgQchrBBCBaHsPjjCBUM5pmgEfr7faFcpHY23QwfjUBmvh9YFG-CJaYyO9tpA28PzZVxap413LTyxXbq13QcVDVx41YfWaRWtS6B317Y2AU69SarfHsS9z1nXDb2NG6gule1DhIs_-8Wl6tNi4OmNDdH2l_CN0rZtDZyotjMxmmw6_Prh02sulNa2Nw_BvUa1wTza1zH48vZ0MZll84_Ts8nreaaLQsQMC0ZrwrUQOSeqxLoUvMB1wximTUlZyZta4SYvdMU4qpq8pkWTl3VRVELVNSFj8GLnu_buajAhys4GbdpW9cYNQXKEOBb4_yAWOSFlymgMnv8Frtzg-zSEzHMicC4KdHDT6aeDN41ce9spv5EYyW3schd7Ap_u3YaqM_UB2-ecgOM9oIJWbZMS0zYcuJJSgjBO3LMd54b1v5s92TGrEJ2_pQhCrGScJz3b6SlEc3OrK_9dUkZYKWdfv8nzT-_wxWz-WX4gvwG_Ftuo</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Pinto, Rachel</creator><creator>Saunders, Bernadette M.</creator><creator>Camacho, Luis R.</creator><creator>Britton, Warwick J.</creator><creator>Gicquel, Brigitte</creator><creator>Triccas, James A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine</title><author>Pinto, Rachel ; Saunders, Bernadette M. ; Camacho, Luis R. ; Britton, Warwick J. ; Gicquel, Brigitte ; Triccas, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-1976d38c99283a51c59841df7716f56758fda1f24cb780bf2d64f25d44b9add33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Bacteria</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Immunity</topic><topic>Immunity, Cellular</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Lesions</topic><topic>Lipids - deficiency</topic><topic>Lipids - genetics</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Mycobacterium bovis</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - enzymology</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - immunology</topic><topic>Spleen</topic><topic>Spleen - immunology</topic><topic>Splenic tuberculosis</topic><topic>T-Lymphocytes - immunology</topic><topic>Transcriptional regulatory elements</topic><topic>Translocation, Genetic</topic><topic>Tuberculosis - immunology</topic><topic>Tuberculosis - prevention & control</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis vaccine</topic><topic>Tuberculosis Vaccines - administration & dosage</topic><topic>Tuberculosis Vaccines - immunology</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinto, Rachel</creatorcontrib><creatorcontrib>Saunders, Bernadette M.</creatorcontrib><creatorcontrib>Camacho, Luis R.</creatorcontrib><creatorcontrib>Britton, Warwick J.</creatorcontrib><creatorcontrib>Gicquel, Brigitte</creatorcontrib><creatorcontrib>Triccas, James A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinto, Rachel</au><au>Saunders, Bernadette M.</au><au>Camacho, Luis R.</au><au>Britton, Warwick J.</au><au>Gicquel, Brigitte</au><au>Triccas, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>189</volume><issue>1</issue><spage>105</spage><epage>112</epage><pages>105-112</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We demonstrate that Mycobacterium tuberculosis that is unable to export the complex lipid phthiocerol dimycocerosate has a decreased capacity to replicate in mice and affords sustained protective immunity against M. tuberculosis infection Protection was significantly better than that provided by the existing vaccine, Mycobacterium bovis bacille Calmette-Guérin (BCG), and this improved protective efficacy was maintained for at least 24 weeks after vaccination. Protection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-γ–secreting cells equal to that induced by virulent M. tuberculosis and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG. These results suggest that the BCG vaccine may be too attenuated to afford effective protective immunity against tuberculosis, and vaccine strains that can provide sustained delivery of mycobacterial antigens are promising antituberculosis vaccine candidates</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14702160</pmid><doi>10.1086/380413</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2004-01, Vol.189 (1), p.105-112 |
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| subjects | Animals Antigens Antigens, Bacterial - immunology Applied microbiology Bacteria Bacterial diseases Biological and medical sciences Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Immunity Immunity, Cellular Infections Infectious diseases Interferon-gamma - biosynthesis Lesions Lipids - deficiency Lipids - genetics Medical sciences Mice Mice, Inbred C57BL Microbiology Mutation Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Spleen Spleen - immunology Splenic tuberculosis T-Lymphocytes - immunology Transcriptional regulatory elements Translocation, Genetic Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis and atypical mycobacterial infections Tuberculosis vaccine Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology |
| title | Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine |
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