Regulation of amylase gene expression in diabetic mice is mediated by a cis-acting upstream element close to the pancreas specific enhancer

We localized the cis-acting sequences that mediate the regulation of a pancreatic amylase gene, Amy-2.2, in diabetic mice. We constructed three hybrid genes containing sequences from the 5'-flanking region of the amylase gene upstream of the heterologous elastase promoter linked to the CAT stru...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 1990-08, Vol.4 (8), p.1316-1321
Hauptverfasser:	KELLER, S. A, ROSENBERG, M. P, JOHNSON, T. M, HOWARD, G, MEISLER, M. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - genetics Amylases - metabolism Animals Base Sequence Biological and medical sciences Cloning, Molecular Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - genetics Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Insulin - metabolism Mice Mice, Transgenic Molecular and cellular biology Molecular genetics Molecular Sequence Data Pancreas - enzymology Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!