Enriching the sequence substitution matrix by structural information

A fundamental step in homology modeling is the comparison of two protein sequences: a probe sequence with an unknown structure and function and a template sequence for which the structure and function are known. The detection of protein similarities relies on a substitution matrix that scores the pr...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2004-01, Vol.54 (1), p.41-48
Hauptverfasser:	Teodorescu, Octavian, Galor, Tamara, Pillardy, Jaroslaw, Elber, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms energy function fitness function sequence alignment Sequence Alignment - methods Sequence Analysis, Protein - methods Sequence Homology, Amino Acid sequence-to-structure matching threading Z-score
Online-Zugang:	Volltext
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