Inhibitory effect of antisense oligodeoxynucleotide to p44／p42 MAPK on angiotensin II-induced hypertrophic response in cultured neonatal rat cardiac myocyte

AIM: To explore the inhibitory effect of antisense oligonucleotide (ODN) to mitogen activated protein kinase(MAPK) on cardiomyocyte hypertrophy induced by angiotensin Ⅱ (Ang Ⅱ). METHODS: A 17-mer phosphorothioate-protected antisense ODN directed against the initiation of translation sites of the p42...

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Veröffentlicht in:	Acta pharmacologica Sinica 2004, Vol.25 (1), p.41-46
Hauptverfasser:	Zhang, Shi-Qin, Ding, Bo, Guo, Zhao-Gui, Li, Yun-Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Animals, Newborn Cardiomegaly - pathology Cells, Cultured Gene Expression - drug effects Genes, fos Genes, myc Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Myocytes, Cardiac - metabolism Oligodeoxyribonucleotides, Antisense - pharmacology Rats Rats, Wistar RNA, Messenger - genetics 促细胞分裂蛋白激酶动物实验反义寡脱氧核苷酸心肌细胞细胞培养细胞肥大反应血管紧张素
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