Macrophages related to Bruch's membrane in age-related macular degeneration
This report describes focal thinning of Bruch's membrane in age-related macular degeneration and suggests a role for macrophages in this process. Electron microscopy was performed on four eyes ranging from normal ageing to age-related macular degeneration with early subretinal neovascularisatio...
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| Veröffentlicht in: | Eye (London) 1990-01, Vol.4 (4), p.613-621 |
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| creator | KILLINGSWORTH, M. C SARKS, J. P SARKS, S. H |
| description | This report describes focal thinning of Bruch's membrane in age-related macular degeneration and suggests a role for macrophages in this process. Electron microscopy was performed on four eyes ranging from normal ageing to age-related macular degeneration with early subretinal neovascularisation. As degeneration progressed multiple segments of thinning of Bruch's membrane were observed and macrophages appeared to engulf fragments of the outer collagenous zone. An associated finding at this stage was the shedding of membranous debris by the retinal pigment epithelium and its deposition within Bruch's membrane. This debris forms the basis of soft drusen but in the presence of this material thinning of Bruch's membrane was also observed beneath hard drusen. It is suggested that the widespread accumulation of phospholipid-containing membranes together with the focal concentration of lipid in hard drusen attract macrophages. |
| doi_str_mv | 10.1038/eye.1990.86 |
| format | Article |
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It is suggested that the widespread accumulation of phospholipid-containing membranes together with the focal concentration of lipid in hard drusen attract macrophages.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.1990.86</identifier><identifier>PMID: 2226993</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Aging - pathology ; Biological and medical sciences ; Choroid - ultrastructure ; Humans ; Macrophages - ultrastructure ; Macular Degeneration - pathology ; Medical sciences ; Microscopy, Electron ; Ophthalmology ; Retinal Drusen - pathology ; Retinopathies</subject><ispartof>Eye (London), 1990-01, Vol.4 (4), p.613-621</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f639a3c47928fbb0921042038dcfa632a9ff6778f8ca82712a4018cabf04fed63</citedby><cites>FETCH-LOGICAL-c417t-f639a3c47928fbb0921042038dcfa632a9ff6778f8ca82712a4018cabf04fed63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19478788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2226993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KILLINGSWORTH, M. 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This debris forms the basis of soft drusen but in the presence of this material thinning of Bruch's membrane was also observed beneath hard drusen. It is suggested that the widespread accumulation of phospholipid-containing membranes together with the focal concentration of lipid in hard drusen attract macrophages.</description><subject>Aging - pathology</subject><subject>Biological and medical sciences</subject><subject>Choroid - ultrastructure</subject><subject>Humans</subject><subject>Macrophages - ultrastructure</subject><subject>Macular Degeneration - pathology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Ophthalmology</subject><subject>Retinal Drusen - pathology</subject><subject>Retinopathies</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAURi0EKuUxMSNlAQaUcu24foxQ8RJFLCCxRY5z3QYlTbGTof8eVw0w-crf0ad7DyFnFCYUMnWDG5xQrWGixB4ZUy5FOuVTvk_GoKeQMsY-D8lRCF8AMZQwIqP4J7TOxuTl1VjfrpdmgSHxWJsOy6Rrkzvf2-VVSBpsCm9WmFSrJDLpL9IY29fGJyUucIXedFW7OiEHztQBT4f3mHw83L_PntL52-Pz7HaeWk5llzqRaZNZLjVTrihAMwqcxUNK64zImNHOCSmVU9YoJikzHGicCwfcYSmyY3K561379rvH0OVNFSzWddyz7UOuAKQWHCJ4vQPjiSF4dPnaV43xm5xCvlWXR3X5Vl2utrXnQ21fNFj-sYOrmF8MuQnW1C5qsVX4r9RcKqlU9gMlUnae</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>KILLINGSWORTH, M. C</creator><creator>SARKS, J. P</creator><creator>SARKS, S. H</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900101</creationdate><title>Macrophages related to Bruch's membrane in age-related macular degeneration</title><author>KILLINGSWORTH, M. C ; SARKS, J. P ; SARKS, S. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophages related to Bruch's membrane in age-related macular degeneration</atitle><jtitle>Eye (London)</jtitle><addtitle>Eye (Lond)</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>4</volume><issue>4</issue><spage>613</spage><epage>621</epage><pages>613-621</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>This report describes focal thinning of Bruch's membrane in age-related macular degeneration and suggests a role for macrophages in this process. Electron microscopy was performed on four eyes ranging from normal ageing to age-related macular degeneration with early subretinal neovascularisation. As degeneration progressed multiple segments of thinning of Bruch's membrane were observed and macrophages appeared to engulf fragments of the outer collagenous zone. An associated finding at this stage was the shedding of membranous debris by the retinal pigment epithelium and its deposition within Bruch's membrane. This debris forms the basis of soft drusen but in the presence of this material thinning of Bruch's membrane was also observed beneath hard drusen. It is suggested that the widespread accumulation of phospholipid-containing membranes together with the focal concentration of lipid in hard drusen attract macrophages.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>2226993</pmid><doi>10.1038/eye.1990.86</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 1990-01, Vol.4 (4), p.613-621 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Aging - pathology Biological and medical sciences Choroid - ultrastructure Humans Macrophages - ultrastructure Macular Degeneration - pathology Medical sciences Microscopy, Electron Ophthalmology Retinal Drusen - pathology Retinopathies |
| title | Macrophages related to Bruch's membrane in age-related macular degeneration |
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