Positive effects of deprenyl and estradiol on spatial memory and oxidant stress in aged female rat brains
Increasing age decreases spatial learning and memory. Spatial learning is coordinated with different brain regions. Since the oxidative damage may play a role in the aging process, including the associated cognitive decline, age-related impairment in spatial learning and memory may be alleviated by...
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| Veröffentlicht in: | Neuroscience letters 2004-01, Vol.354 (3), p.225-228 |
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| creator | Kiray, Müge Uysal, Nazan Sönmez, Ataç Açıkgöz, Osman Gönenç, Sevil |
| description | Increasing age decreases spatial learning and memory. Spatial learning is coordinated with different brain regions. Since the oxidative damage may play a role in the aging process, including the associated cognitive decline, age-related impairment in spatial learning and memory may be alleviated by antioxidant treatment. The present study examined the effects of the monoamine oxidase B inhibitor
l-deprenyl, alone and in combination with estradiol, on spatial memory using the Morris water maze and oxidant stress in aged female rat brains. We demonstrated that co-administration of deprenyl and estradiol caused a synergistic effect on spatial memory. However, use of either deprenyl or estradiol alone increased antioxidant enzyme activities in brain and reduced lipid peroxidation. Therefore, positive effects of deprenyl and estradiol on spatial memory may occur due not only to their antioxidant activities but also to the different actions. |
| doi_str_mv | 10.1016/j.neulet.2003.10.019 |
| format | Article |
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l-deprenyl, alone and in combination with estradiol, on spatial memory using the Morris water maze and oxidant stress in aged female rat brains. We demonstrated that co-administration of deprenyl and estradiol caused a synergistic effect on spatial memory. However, use of either deprenyl or estradiol alone increased antioxidant enzyme activities in brain and reduced lipid peroxidation. Therefore, positive effects of deprenyl and estradiol on spatial memory may occur due not only to their antioxidant activities but also to the different actions.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2003.10.019</identifier><identifier>PMID: 14700737</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age Factors ; Animals ; Antioxidant enzymes ; Biological and medical sciences ; Brain - anatomy & histology ; Brain - drug effects ; Brain - physiology ; Deprenyl ; Estradiol ; Estradiol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Glutathione Peroxidase - metabolism ; Lipid peroxidation ; Maze Learning - drug effects ; Memory - drug effects ; Neuroprotective Agents - pharmacology ; Oxidative Stress - drug effects ; Rat ; Rats ; Selegiline - pharmacology ; Spatial Behavior - drug effects ; Spatial memory ; Thiobarbituric Acid Reactive Substances - metabolism ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-01, Vol.354 (3), p.225-228</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-a4f117f12b46392c227e8a02ce4dd3d459757233363f371e0efb5b3d1d494e563</citedby><cites>FETCH-LOGICAL-c388t-a4f117f12b46392c227e8a02ce4dd3d459757233363f371e0efb5b3d1d494e563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2003.10.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15383736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14700737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiray, Müge</creatorcontrib><creatorcontrib>Uysal, Nazan</creatorcontrib><creatorcontrib>Sönmez, Ataç</creatorcontrib><creatorcontrib>Açıkgöz, Osman</creatorcontrib><creatorcontrib>Gönenç, Sevil</creatorcontrib><title>Positive effects of deprenyl and estradiol on spatial memory and oxidant stress in aged female rat brains</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Increasing age decreases spatial learning and memory. Spatial learning is coordinated with different brain regions. Since the oxidative damage may play a role in the aging process, including the associated cognitive decline, age-related impairment in spatial learning and memory may be alleviated by antioxidant treatment. The present study examined the effects of the monoamine oxidase B inhibitor
l-deprenyl, alone and in combination with estradiol, on spatial memory using the Morris water maze and oxidant stress in aged female rat brains. We demonstrated that co-administration of deprenyl and estradiol caused a synergistic effect on spatial memory. However, use of either deprenyl or estradiol alone increased antioxidant enzyme activities in brain and reduced lipid peroxidation. Therefore, positive effects of deprenyl and estradiol on spatial memory may occur due not only to their antioxidant activities but also to the different actions.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antioxidant enzymes</subject><subject>Biological and medical sciences</subject><subject>Brain - anatomy & histology</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Deprenyl</subject><subject>Estradiol</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Lipid peroxidation</subject><subject>Maze Learning - drug effects</subject><subject>Memory - drug effects</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Rat</subject><subject>Rats</subject><subject>Selegiline - pharmacology</subject><subject>Spatial Behavior - drug effects</subject><subject>Spatial memory</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1qGzEUhUVpaFy3b1CKNs1uHP2NNbMplJD-QKBdtGtxR7oqMhrJlcYhfvvKtSG7rgRX3z0cfSLkHWcbzvj2drdJeIi4bARjso02jI8vyIoPWnR61OIlWTHJVCdHxa7J61p3jLGe9-oVueZKM6alXpHwI9ewhEek6D3apdLsqcN9wXSMFJKjWJcCLuRIc6J1D0uASGecczn-u89PwUFaaMOwVhoShd_oqMcZItICC50KhFTfkCsPseLby7kmvz7f_7z72j18__Lt7tNDZ-UwLB0oz7n2XExqK0dhhdA4ABMWlXPSqX7UvRZSyq30UnNk6Kd-ko47NSrst3JNbs65-5L_HFp7M4dqMUZImA_VDO3lo2oJa6LOoC251oLe7EuYoRwNZ-ak2OzMWbE5KT5Nm-K29v6Sf5hmdM9LF6cN-HABoFqIvkCyoT5zvRwadSr68cxhs_EYsJhqAyaLLpT2E8bl8P8mfwEIhZxW</recordid><startdate>20040116</startdate><enddate>20040116</enddate><creator>Kiray, Müge</creator><creator>Uysal, Nazan</creator><creator>Sönmez, Ataç</creator><creator>Açıkgöz, Osman</creator><creator>Gönenç, Sevil</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040116</creationdate><title>Positive effects of deprenyl and estradiol on spatial memory and oxidant stress in aged female rat brains</title><author>Kiray, Müge ; Uysal, Nazan ; Sönmez, Ataç ; Açıkgöz, Osman ; Gönenç, Sevil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-a4f117f12b46392c227e8a02ce4dd3d459757233363f371e0efb5b3d1d494e563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Antioxidant enzymes</topic><topic>Biological and medical sciences</topic><topic>Brain - anatomy & histology</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Deprenyl</topic><topic>Estradiol</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Spatial learning is coordinated with different brain regions. Since the oxidative damage may play a role in the aging process, including the associated cognitive decline, age-related impairment in spatial learning and memory may be alleviated by antioxidant treatment. The present study examined the effects of the monoamine oxidase B inhibitor
l-deprenyl, alone and in combination with estradiol, on spatial memory using the Morris water maze and oxidant stress in aged female rat brains. We demonstrated that co-administration of deprenyl and estradiol caused a synergistic effect on spatial memory. However, use of either deprenyl or estradiol alone increased antioxidant enzyme activities in brain and reduced lipid peroxidation. Therefore, positive effects of deprenyl and estradiol on spatial memory may occur due not only to their antioxidant activities but also to the different actions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14700737</pmid><doi>10.1016/j.neulet.2003.10.019</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2004-01, Vol.354 (3), p.225-228 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age Factors Animals Antioxidant enzymes Biological and medical sciences Brain - anatomy & histology Brain - drug effects Brain - physiology Deprenyl Estradiol Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - metabolism Lipid peroxidation Maze Learning - drug effects Memory - drug effects Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Rat Rats Selegiline - pharmacology Spatial Behavior - drug effects Spatial memory Thiobarbituric Acid Reactive Substances - metabolism Time Factors Vertebrates: nervous system and sense organs |
| title | Positive effects of deprenyl and estradiol on spatial memory and oxidant stress in aged female rat brains |
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