Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome
In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregna...
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| Veröffentlicht in: | Fertility and sterility 1990-11, Vol.54 (5), p.853-857 |
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| container_title | Fertility and sterility |
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| creator | Edelstein, Michael C. Seltman, Howard J. Cox, Beverly J. Robinson, Shirley M. Shaw, Ruth A. Muasher, Suheil J. |
| description | In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregnancy rate. We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P |
| doi_str_mv | 10.1016/S0015-0282(16)53945-4 |
| format | Article |
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We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P<0.9ng/mL and 29 had P≥0.9ng/mL. Patients in the high P group had a significantly greater estradiol level on the day of hCG. No significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low P and high P groups. We conclude that in IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)53945-4</identifier><identifier>PMID: 2121554</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Antineoplastic Agents - pharmacology ; Chorionic Gonadotropin - administration & dosage ; Chorionic Gonadotropin - pharmacology ; Female ; Fertilization in Vitro ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gonadotropin-Releasing Hormone - pharmacology ; Humans ; Injections, Subcutaneous ; Leuprolide ; Luteinizing Hormone - blood ; Pregnancy ; Pregnancy Outcome - epidemiology ; Progesterone - blood ; Retrospective Studies</subject><ispartof>Fertility and sterility, 1990-11, Vol.54 (5), p.853-857</ispartof><rights>1990 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-9c8a9691ef5627c41713d9d3d2a30fa080d3e89e2b00f1cccacafb6c1d82c8503</citedby><cites>FETCH-LOGICAL-c459t-9c8a9691ef5627c41713d9d3d2a30fa080d3e89e2b00f1cccacafb6c1d82c8503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216539454$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2121554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edelstein, Michael C.</creatorcontrib><creatorcontrib>Seltman, Howard J.</creatorcontrib><creatorcontrib>Cox, Beverly J.</creatorcontrib><creatorcontrib>Robinson, Shirley M.</creatorcontrib><creatorcontrib>Shaw, Ruth A.</creatorcontrib><creatorcontrib>Muasher, Suheil J.</creatorcontrib><title>Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregnancy rate. We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P<0.9ng/mL and 29 had P≥0.9ng/mL. Patients in the high P group had a significantly greater estradiol level on the day of hCG. No significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low P and high P groups. We conclude that in IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle.</description><subject>Adult</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Humans</subject><subject>Injections, Subcutaneous</subject><subject>Leuprolide</subject><subject>Luteinizing Hormone - blood</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Progesterone - blood</subject><subject>Retrospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFu1DAQtRCoLIVPqOQTgkPAdmJvckKoKrRSpVYqnC3veLJrlNjBdhbtl_F7ON1VJU49jWbee_NG8wi54OwTZ1x9fmCMy4qJVnzg6qOsu0ZWzQuy4lKqSipZvySrJ8pr8ialX4wxxdfijJwJLgqvWZG_9zFsMWWMwSMdcI9DosHTvENqzYGGnu7m0XgKuxBd8A7oNnhjQ45hcp4aOzrvUo4mF5SWCRxgwET_uLz7j1pFHNAk57e0rBoXO1PwoqVpnqaIKS0bTETqQ6ZlYB1kt8flhtJtvfFQDpozhBHfkle9GRK-O9Vz8vPb1Y_L6-r27vvN5dfbChrZ5aqD1nSq49hLJdbQ8DWvbWdrK0zNesNaZmtsOxQbxnoOAAZMv1HAbSuglaw-J--Pe6cYfs_lUXp0CXAYjMcwJ90ytu5qxQtRHokQQ0oRez1FN5p40JzpJTD9GJhe0tClewxMN0V3cTKYNyPaJ9UpoYJ_OeIlGNw7jDqBQw_lOxEhaxvcMw7_AAcOrCY</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Edelstein, Michael C.</creator><creator>Seltman, Howard J.</creator><creator>Cox, Beverly J.</creator><creator>Robinson, Shirley M.</creator><creator>Shaw, Ruth A.</creator><creator>Muasher, Suheil J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901101</creationdate><title>Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome</title><author>Edelstein, Michael C. ; Seltman, Howard J. ; Cox, Beverly J. ; Robinson, Shirley M. ; Shaw, Ruth A. ; Muasher, Suheil J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-9c8a9691ef5627c41713d9d3d2a30fa080d3e89e2b00f1cccacafb6c1d82c8503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Humans</topic><topic>Injections, Subcutaneous</topic><topic>Leuprolide</topic><topic>Luteinizing Hormone - blood</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Progesterone - blood</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edelstein, Michael C.</creatorcontrib><creatorcontrib>Seltman, Howard J.</creatorcontrib><creatorcontrib>Cox, Beverly J.</creatorcontrib><creatorcontrib>Robinson, Shirley M.</creatorcontrib><creatorcontrib>Shaw, Ruth A.</creatorcontrib><creatorcontrib>Muasher, Suheil J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edelstein, Michael C.</au><au>Seltman, Howard J.</au><au>Cox, Beverly J.</au><au>Robinson, Shirley M.</au><au>Shaw, Ruth A.</au><au>Muasher, Suheil J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>54</volume><issue>5</issue><spage>853</spage><epage>857</epage><pages>853-857</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregnancy rate. We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P<0.9ng/mL and 29 had P≥0.9ng/mL. Patients in the high P group had a significantly greater estradiol level on the day of hCG. No significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low P and high P groups. We conclude that in IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2121554</pmid><doi>10.1016/S0015-0282(16)53945-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Antineoplastic Agents - pharmacology Chorionic Gonadotropin - administration & dosage Chorionic Gonadotropin - pharmacology Female Fertilization in Vitro Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - pharmacology Humans Injections, Subcutaneous Leuprolide Luteinizing Hormone - blood Pregnancy Pregnancy Outcome - epidemiology Progesterone - blood Retrospective Studies |
| title | Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome |
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