Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
Transcription factors GATA-1 and GATA-2 are required for normal hematopoiesis. The loss of either leads to embryonic lethality in knockout mice because of the failure of erythroid maturation and the expansion of progenitors, respectively. As the expression of GATA-1 and GATA-2 overlaps within hemato...
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| Veröffentlicht in: | Blood 2004-01, Vol.103 (2), p.583-585 |
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| creator | Fujiwara, Yuko Chang, Aaron N. Williams, Aimée M. Orkin, Stuart H. |
| description | Transcription factors GATA-1 and GATA-2 are required for normal hematopoiesis. The loss of either leads to embryonic lethality in knockout mice because of the failure of erythroid maturation and the expansion of progenitors, respectively. As the expression of GATA-1 and GATA-2 overlaps within hematopoietic progenitors, the extent to which these factors functionally compensate for each other during embryogenesis is unknown. As shown here, we have analyzed double-knockout embryos at the yolk sac stage of development and have shown that the combined absence of these GATA factors virtually ablates primitive erythroid cell formation. Thus, the function of GATA-1 and GATA-2 overlaps at the yolk sac stage. Moreover, a GATA factor, either GATA-1 or GATA-2, is required to initiate blood formation in the embryo. |
| doi_str_mv | 10.1182/blood-2003-08-2870 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Crosses, Genetic DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Erythroid-Specific DNA-Binding Factors Female Fundamental and applied biological sciences. Psychology GATA1 Transcription Factor GATA2 Transcription Factor Hematopoiesis - genetics Humans Male Mice Mice, Knockout Mice, Transgenic Molecular and cellular biology Testis - pathology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology Yolk Sac - pathology |
| title | Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development |
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