Squaric Acids:  A New Motif for Designing Inhibitors of Protein Tyrosine Phosphatases

Protein tyrosine phosphatases (PTPases) are important targets in medicinal chemistry. These enzymes play a role in a number of human diseases, including type II diabetes and infection by Yersinia pestis, the causative agent of bubonic plague. Derivatives of squaric acids such as 2-aryl-1-hydroxycycl...

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Veröffentlicht in:	Organic letters 2004-01, Vol.6 (1), p.83-86
Hauptverfasser:	Xie, Jian, Comeau, Anthony B, Seto, Christopher T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Cyclobutanes - chemistry Cyclobutanes - pharmacology Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Models, Chemical Molecular Structure Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - chemistry
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