Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke
Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases an...
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| Veröffentlicht in: | Stroke (1970) 2004, Vol.35 (1), p.163-168 |
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| container_title | Stroke (1970) |
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| creator | SANCHEZ-MORENO, Concepcion DASHE, John F SCOTT, Tammy THALER, David FOLSTEIN, Marshal F MARTIN, Antonio |
| description | Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was associated with levels of inflammatory markers and oxidative stress among cases and controls.
We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects.
Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF2alpha, but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF2alpha among stroke patients, and 8-epiPGF2alpha was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients.
Lower vitamin C concentration, higher serum levels of inflammatory (CRP, ICAM-1, MCP-1) and oxidative stress (8-epiPGF2alpha) markers, and lower PGI2 and PGE2 concentrations among stroke patients indicate the presence of an inflammatory response associated with stroke. |
| doi_str_mv | 10.1161/01.STR.0000105391.62306.2E |
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We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects.
Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF2alpha, but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF2alpha among stroke patients, and 8-epiPGF2alpha was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients.
Lower vitamin C concentration, higher serum levels of inflammatory (CRP, ICAM-1, MCP-1) and oxidative stress (8-epiPGF2alpha) markers, and lower PGI2 and PGE2 concentrations among stroke patients indicate the presence of an inflammatory response associated with stroke.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000105391.62306.2E</identifier><identifier>PMID: 14671251</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Antioxidants - analysis ; Ascorbic Acid - blood ; Biological and medical sciences ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - complications ; C-Reactive Protein - analysis ; Chemokine CCL2 - blood ; Cytokines - blood ; Diet ; Dinoprost - analogs & derivatives ; Dinoprost - blood ; Humans ; Inflammation Mediators - blood ; Intercellular Adhesion Molecule-1 - blood ; Medical sciences ; Middle Aged ; Neurology ; Neuropsychological Tests ; Nutritional Status ; Oxidative Stress ; Prostaglandins - blood ; Reference Values ; Stroke - blood ; Stroke - complications ; Time Factors ; Uric Acid - blood ; Vascular diseases and vascular malformations of the nervous system ; Vitamin E - blood</subject><ispartof>Stroke (1970), 2004, Vol.35 (1), p.163-168</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b5e4e556bbb57e8054c311939542ce9302dda9b791f9f4af4460d31e2734d5ec3</citedby><cites>FETCH-LOGICAL-c498t-b5e4e556bbb57e8054c311939542ce9302dda9b791f9f4af4460d31e2734d5ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15515121$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14671251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANCHEZ-MORENO, Concepcion</creatorcontrib><creatorcontrib>DASHE, John F</creatorcontrib><creatorcontrib>SCOTT, Tammy</creatorcontrib><creatorcontrib>THALER, David</creatorcontrib><creatorcontrib>FOLSTEIN, Marshal F</creatorcontrib><creatorcontrib>MARTIN, Antonio</creatorcontrib><title>Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was associated with levels of inflammatory markers and oxidative stress among cases and controls.
We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects.
Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF2alpha, but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF2alpha among stroke patients, and 8-epiPGF2alpha was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients.
Lower vitamin C concentration, higher serum levels of inflammatory (CRP, ICAM-1, MCP-1) and oxidative stress (8-epiPGF2alpha) markers, and lower PGI2 and PGE2 concentrations among stroke patients indicate the presence of an inflammatory response associated with stroke.</description><subject>Aged</subject><subject>Antioxidants - analysis</subject><subject>Ascorbic Acid - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - complications</subject><subject>C-Reactive Protein - analysis</subject><subject>Chemokine CCL2 - blood</subject><subject>Cytokines - blood</subject><subject>Diet</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - blood</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Nutritional Status</subject><subject>Oxidative Stress</subject><subject>Prostaglandins - blood</subject><subject>Reference Values</subject><subject>Stroke - blood</subject><subject>Stroke - complications</subject><subject>Time Factors</subject><subject>Uric Acid - blood</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vitamin E - blood</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkG9rFDEQh4NY7Fn9ChIEfbdrJn92N76T61mFQqHW1yGbnUDsbnIme4elX97t9crlzUDm-c0MDyEfgdUADXxhUP-6u63Z8oApoaFuuGBNzTevyAoUl5VsePearBgTuuJS63PytpQ_C89Fp96Qc5BNC1zBijxeostoCw50xD2OhSZPt6Mtk6X7MNspRLqmNg40xBfQpegwztnOIcVDIEQ_2mmyc8oPBzj9C8PS3iMtc8ZS6GTzPeZCrZ8xP32me3xHzrwdC74_1gvy-_vmbv2jur65-rn-dl05qbu56hVKVKrp-1612DElnQDQQivJHWrB-DBY3bcavPbSeikbNghA3go5KHTignx-nrvN6e8Oy2ymUByOo42YdsV0jLVKSLmAX59Bl1MpGb3Z5rBc_mCAmSf1hoFZ1JuTenNQb_hmCX84btn1Ew6n6NH1Anw6ArY4O_psowvlxCkFCjiI_0qhjxY</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>SANCHEZ-MORENO, Concepcion</creator><creator>DASHE, John F</creator><creator>SCOTT, Tammy</creator><creator>THALER, David</creator><creator>FOLSTEIN, Marshal F</creator><creator>MARTIN, Antonio</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke</title><author>SANCHEZ-MORENO, Concepcion ; DASHE, John F ; SCOTT, Tammy ; THALER, David ; FOLSTEIN, Marshal F ; MARTIN, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b5e4e556bbb57e8054c311939542ce9302dda9b791f9f4af4460d31e2734d5ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Antioxidants - analysis</topic><topic>Ascorbic Acid - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - complications</topic><topic>C-Reactive Protein - analysis</topic><topic>Chemokine CCL2 - blood</topic><topic>Cytokines - blood</topic><topic>Diet</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - blood</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Nutritional Status</topic><topic>Oxidative Stress</topic><topic>Prostaglandins - blood</topic><topic>Reference Values</topic><topic>Stroke - blood</topic><topic>Stroke - complications</topic><topic>Time Factors</topic><topic>Uric Acid - blood</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANCHEZ-MORENO, Concepcion</creatorcontrib><creatorcontrib>DASHE, John F</creatorcontrib><creatorcontrib>SCOTT, Tammy</creatorcontrib><creatorcontrib>THALER, David</creatorcontrib><creatorcontrib>FOLSTEIN, Marshal F</creatorcontrib><creatorcontrib>MARTIN, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANCHEZ-MORENO, Concepcion</au><au>DASHE, John F</au><au>SCOTT, Tammy</au><au>THALER, David</au><au>FOLSTEIN, Marshal F</au><au>MARTIN, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2004</date><risdate>2004</risdate><volume>35</volume><issue>1</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was associated with levels of inflammatory markers and oxidative stress among cases and controls.
We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-alpha and interleukin-1beta, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF2alpha) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects.
Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF2alpha, but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF2alpha among stroke patients, and 8-epiPGF2alpha was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients.
Lower vitamin C concentration, higher serum levels of inflammatory (CRP, ICAM-1, MCP-1) and oxidative stress (8-epiPGF2alpha) markers, and lower PGI2 and PGE2 concentrations among stroke patients indicate the presence of an inflammatory response associated with stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14671251</pmid><doi>10.1161/01.STR.0000105391.62306.2E</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Antioxidants - analysis Ascorbic Acid - blood Biological and medical sciences Biomarkers - blood Brain Ischemia - blood Brain Ischemia - complications C-Reactive Protein - analysis Chemokine CCL2 - blood Cytokines - blood Diet Dinoprost - analogs & derivatives Dinoprost - blood Humans Inflammation Mediators - blood Intercellular Adhesion Molecule-1 - blood Medical sciences Middle Aged Neurology Neuropsychological Tests Nutritional Status Oxidative Stress Prostaglandins - blood Reference Values Stroke - blood Stroke - complications Time Factors Uric Acid - blood Vascular diseases and vascular malformations of the nervous system Vitamin E - blood |
| title | Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke |
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