Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains
Reactive oxygen species can be scavenged by superoxide dismutase (SOD) and glutathione peroxidase (GPx). During ischemia-reperfusion, the normal functioning of these antioxidant enzymes may be insufficient for the prevention of oxidant-induced peroxidation of membrane lipids and hence cerebral infar...
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| Veröffentlicht in: | Neuroscience letters 2004-01, Vol.354 (2), p.158-162 |
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| creator | Siu, Flora K.W. Lo, Samuel C.L. Leung, Mason C.P. |
| description | Reactive oxygen species can be scavenged by superoxide dismutase (SOD) and glutathione peroxidase (GPx). During ischemia-reperfusion, the normal functioning of these antioxidant enzymes may be insufficient for the prevention of oxidant-induced peroxidation of membrane lipids and hence cerebral infarction. We therefore investigated whether electroacupuncture (EA) treatment at
Fengchi points in post-ischemic rats could increase the antioxidant enzyme activities and thereby reduce the extent of lipid peroxidation. The results indicated that while EA did not alter the antioxidant enzyme activities in non-ischemic normal rat brains, ischemia-reperfusion caused significant increases in SOD and GPx activities. EA treatment further increased the antioxidant enzyme activities in ischemic-reperfused brain tissues, with a concomitant decrease in the extent of lipid peroxidation. Our finding suggests that EA treatment at
Fengchi reduced the extent of lipid peroxidation in ischemic-reperfused rat brains, possibly by increasing the activities of SOD and GPx. |
| doi_str_mv | 10.1016/j.neulet.2003.10.009 |
| format | Article |
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Fengchi points in post-ischemic rats could increase the antioxidant enzyme activities and thereby reduce the extent of lipid peroxidation. The results indicated that while EA did not alter the antioxidant enzyme activities in non-ischemic normal rat brains, ischemia-reperfusion caused significant increases in SOD and GPx activities. EA treatment further increased the antioxidant enzyme activities in ischemic-reperfused brain tissues, with a concomitant decrease in the extent of lipid peroxidation. Our finding suggests that EA treatment at
Fengchi reduced the extent of lipid peroxidation in ischemic-reperfused rat brains, possibly by increasing the activities of SOD and GPx.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2003.10.009</identifier><identifier>PMID: 14698462</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Brain - enzymology ; Brain - physiopathology ; Brain Ischemia - metabolism ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Cerebral ischemia ; Disease Models, Animal ; Electroacupuncture ; Fundamental and applied biological sciences. Psychology ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Lipid peroxidation ; Lipid Peroxidation - physiology ; Male ; Medical sciences ; Neurology ; Rats ; Reperfusion Injury - metabolism ; Reperfusion Injury - physiopathology ; Reperfusion Injury - therapy ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Up-Regulation - physiology ; Vascular diseases and vascular malformations of the nervous system ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-01, Vol.354 (2), p.158-162</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-3cdfe735712d7890cc316950a1c3d796657a198d2c76bc66e1a0444a73e306633</citedby><cites>FETCH-LOGICAL-c419t-3cdfe735712d7890cc316950a1c3d796657a198d2c76bc66e1a0444a73e306633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2003.10.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15383555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14698462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siu, Flora K.W.</creatorcontrib><creatorcontrib>Lo, Samuel C.L.</creatorcontrib><creatorcontrib>Leung, Mason C.P.</creatorcontrib><title>Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Reactive oxygen species can be scavenged by superoxide dismutase (SOD) and glutathione peroxidase (GPx). During ischemia-reperfusion, the normal functioning of these antioxidant enzymes may be insufficient for the prevention of oxidant-induced peroxidation of membrane lipids and hence cerebral infarction. We therefore investigated whether electroacupuncture (EA) treatment at
Fengchi points in post-ischemic rats could increase the antioxidant enzyme activities and thereby reduce the extent of lipid peroxidation. The results indicated that while EA did not alter the antioxidant enzyme activities in non-ischemic normal rat brains, ischemia-reperfusion caused significant increases in SOD and GPx activities. EA treatment further increased the antioxidant enzyme activities in ischemic-reperfused brain tissues, with a concomitant decrease in the extent of lipid peroxidation. Our finding suggests that EA treatment at
Fengchi reduced the extent of lipid peroxidation in ischemic-reperfused rat brains, possibly by increasing the activities of SOD and GPx.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - enzymology</subject><subject>Brain - physiopathology</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - physiopathology</subject><subject>Brain Ischemia - therapy</subject><subject>Cerebral ischemia</subject><subject>Disease Models, Animal</subject><subject>Electroacupuncture</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Rats</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Reperfusion Injury - therapy</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Up-Regulation - physiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhHyDkC9yyjOPYji9IqCofUiUucLa89qTrVeIs_qjaP8TvrFcb0RucbM0873jkp2neUthSoOLjYRuwTJi3HQCrpS2AetZs6CC7VirZPW82wKBvmerhonmV0gEAOOX9y-aC9kINveg2zZ_rCW2Oi7HlWILNJSKJ6IrFRPIeCd5nDJksI5n80TtyxLjce2eyXwLZPRAfbESTfLglqaxNJM6nuWSTkJjgyO1U73lfE_g3f2rZ7O989vUlH4hPdo-zt23EyowloSPRZLKLxof0unkxminhm_W8bH59uf559a29-fH1-9Xnm9b2VOWWWTeiZFzSzslBgbWMCsXBUMucVEJwaagaXGel2FkhkBro-95IhgyEYOyy-XCee4zL74Ip67kuhtNkAi4l6QFAcqrEf0EqJXQCZAX7M2jjklLEUR-jn0180BT0SaQ-6LNIfRJ5qlaRNfZunV92M7qn0GquAu9XwCRrpjGaYH164jgbGOe8cp_OHNZvu_MYdbIeg0XnYzWv3eL_vckjEc7ChA</recordid><startdate>20040109</startdate><enddate>20040109</enddate><creator>Siu, Flora K.W.</creator><creator>Lo, Samuel C.L.</creator><creator>Leung, Mason C.P.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040109</creationdate><title>Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains</title><author>Siu, Flora K.W. ; Lo, Samuel C.L. ; Leung, Mason C.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-3cdfe735712d7890cc316950a1c3d796657a198d2c76bc66e1a0444a73e306633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - enzymology</topic><topic>Brain - physiopathology</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - physiopathology</topic><topic>Brain Ischemia - therapy</topic><topic>Cerebral ischemia</topic><topic>Disease Models, Animal</topic><topic>Electroacupuncture</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Rats</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Reperfusion Injury - therapy</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Up-Regulation - physiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siu, Flora K.W.</creatorcontrib><creatorcontrib>Lo, Samuel C.L.</creatorcontrib><creatorcontrib>Leung, Mason C.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siu, Flora K.W.</au><au>Lo, Samuel C.L.</au><au>Leung, Mason C.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2004-01-09</date><risdate>2004</risdate><volume>354</volume><issue>2</issue><spage>158</spage><epage>162</epage><pages>158-162</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Reactive oxygen species can be scavenged by superoxide dismutase (SOD) and glutathione peroxidase (GPx). During ischemia-reperfusion, the normal functioning of these antioxidant enzymes may be insufficient for the prevention of oxidant-induced peroxidation of membrane lipids and hence cerebral infarction. We therefore investigated whether electroacupuncture (EA) treatment at
Fengchi points in post-ischemic rats could increase the antioxidant enzyme activities and thereby reduce the extent of lipid peroxidation. The results indicated that while EA did not alter the antioxidant enzyme activities in non-ischemic normal rat brains, ischemia-reperfusion caused significant increases in SOD and GPx activities. EA treatment further increased the antioxidant enzyme activities in ischemic-reperfused brain tissues, with a concomitant decrease in the extent of lipid peroxidation. Our finding suggests that EA treatment at
Fengchi reduced the extent of lipid peroxidation in ischemic-reperfused rat brains, possibly by increasing the activities of SOD and GPx.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14698462</pmid><doi>10.1016/j.neulet.2003.10.009</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Brain - enzymology Brain - physiopathology Brain Ischemia - metabolism Brain Ischemia - physiopathology Brain Ischemia - therapy Cerebral ischemia Disease Models, Animal Electroacupuncture Fundamental and applied biological sciences. Psychology Glutathione peroxidase Glutathione Peroxidase - metabolism Lipid peroxidation Lipid Peroxidation - physiology Male Medical sciences Neurology Rats Reperfusion Injury - metabolism Reperfusion Injury - physiopathology Reperfusion Injury - therapy Superoxide dismutase Superoxide Dismutase - metabolism Up-Regulation - physiology Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs |
| title | Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains |
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