Artificial Modules for Enhancing Rate Constants of a Group I Intron Ribozyme without a P4-P6 Core Element

In this paper we report newly selected artificial modules that enhance the kcat values comparable with or higher than those of the wild-type ribozyme with broad substrate specificity. The elements required for the catalysis of Group I intron ribozymes are concentrated in the P3-P7 domain of their co...

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Veröffentlicht in:	The Journal of biological chemistry 2004-01, Vol.279 (1), p.540-546
Hauptverfasser:	Ohuchi, Shoji J., Ikawa, Yoshiya, Shiraishi, Hideaki, Inoue, Tan
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Buffers Introns Kinetics Models, Molecular Molecular Sequence Data Morpholines Nucleic Acid Conformation Oligodeoxyribonucleotides RNA, Catalytic - chemistry RNA, Catalytic - genetics
Online-Zugang:	Volltext
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