Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 ± 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment im...
Gespeichert in:
| Veröffentlicht in: | The American journal of cardiology 2004, Vol.93 (1), p.84-88 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 88 |
|---|---|
| container_issue | 1 |
| container_start_page | 84 |
| container_title | The American journal of cardiology |
| container_volume | 93 |
| creator | Wassmann, Sven Ribaudo, Nicole Faul, Anna Laufs, Ulrich Böhm, Michael Nickenig, Georg |
| description | The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 ± 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation. |
| doi_str_mv | 10.1016/j.amjcard.2003.09.018 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80073567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914903013353</els_id><sourcerecordid>80073567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-fc607e7cdb26972fbec542b351f57338c50c69f081f1730df4f5a66f557e97f33</originalsourceid><addsrcrecordid>eNqFkcGK1TAUhoMozp3RR1CyUXTRTtI0TQOCyDCjwoAbXYc0PfHmkjY1Se8wb-RjmnIvzNJVSPL95_zn_Ai9oaSmhHbXh1pPB6PjWDeEsJrImtD-GdrRXsiKSsqeox0hpKkkbeUFukzpUK6U8u4luqBtJ0Ur2A79vbUWTMbBYp1DPOqUdXYz7gmefuMwY5jHkPfgnfbYgPfYrrPJrvx8sCGCjhMefAgjtj48fMRFupQCMOeEH1ze4yVCLlieyhNOENcJF7AaYU4uP2LvlrDEkKEIzT54SBli8NjDEXzCnyjbjFyP_hV6YbVP8Pp8XqFfd7c_b75V9z--fr_5cl8ZJmmurOmIAGHGoSkjNnYAw9tmYJxaLhjrDSemk5b01FLByGhby3XXWc4FSGEZu0LvT3WLqz9rsaMml7bB9QxhTaonRDDeiQLyE2hiSCmCVUt0k46PihK1RaQO6hyR2iJSRKoSUdG9PTdYhwnGJ9U5kwK8OwM6Ge1t1LNx6Ynb5qBUFu7ziSuLgqODqJIpizcwulgiVWNw_7HyD26atM8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80073567</pqid></control><display><type>article</type><title>Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wassmann, Sven ; Ribaudo, Nicole ; Faul, Anna ; Laufs, Ulrich ; Böhm, Michael ; Nickenig, Georg</creator><creatorcontrib>Wassmann, Sven ; Ribaudo, Nicole ; Faul, Anna ; Laufs, Ulrich ; Böhm, Michael ; Nickenig, Georg</creatorcontrib><description>The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 ± 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2003.09.018</identifier><identifier>PMID: 14697473</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Anticholesteremic Agents - administration & dosage ; Anticholesteremic Agents - pharmacology ; Anticholesteremic Agents - therapeutic use ; Atorvastatin ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Brachial Artery - drug effects ; Brachial Artery - physiology ; Cardiology. Vascular system ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Double-Blind Method ; Drug Administration Schedule ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Female ; Forearm - blood supply ; Heart ; Heptanoic Acids - administration & dosage ; Heptanoic Acids - pharmacology ; Heptanoic Acids - therapeutic use ; Humans ; Hypercholesterolemia - blood ; Hypercholesterolemia - drug therapy ; Hypercholesterolemia - physiopathology ; Hyperemia - blood ; Hyperemia - drug therapy ; Hyperemia - physiopathology ; Male ; Medical sciences ; Middle Aged ; Nitroglycerin - pharmacology ; Pulsatile Flow - drug effects ; Pyrroles - administration & dosage ; Pyrroles - pharmacology ; Pyrroles - therapeutic use ; Treatment Outcome ; Triglycerides - blood ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>The American journal of cardiology, 2004, Vol.93 (1), p.84-88</ispartof><rights>2003 Excerpta Medica Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-fc607e7cdb26972fbec542b351f57338c50c69f081f1730df4f5a66f557e97f33</citedby><cites>FETCH-LOGICAL-c391t-fc607e7cdb26972fbec542b351f57338c50c69f081f1730df4f5a66f557e97f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2003.09.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15733119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14697473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wassmann, Sven</creatorcontrib><creatorcontrib>Ribaudo, Nicole</creatorcontrib><creatorcontrib>Faul, Anna</creatorcontrib><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Böhm, Michael</creatorcontrib><creatorcontrib>Nickenig, Georg</creatorcontrib><title>Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 ± 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation.</description><subject>Administration, Oral</subject><subject>Anticholesteremic Agents - administration & dosage</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Atorvastatin</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Heart</subject><subject>Heptanoic Acids - administration & dosage</subject><subject>Heptanoic Acids - pharmacology</subject><subject>Heptanoic Acids - therapeutic use</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Hypercholesterolemia - physiopathology</subject><subject>Hyperemia - blood</subject><subject>Hyperemia - drug therapy</subject><subject>Hyperemia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitroglycerin - pharmacology</subject><subject>Pulsatile Flow - drug effects</subject><subject>Pyrroles - administration & dosage</subject><subject>Pyrroles - pharmacology</subject><subject>Pyrroles - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGK1TAUhoMozp3RR1CyUXTRTtI0TQOCyDCjwoAbXYc0PfHmkjY1Se8wb-RjmnIvzNJVSPL95_zn_Ai9oaSmhHbXh1pPB6PjWDeEsJrImtD-GdrRXsiKSsqeox0hpKkkbeUFukzpUK6U8u4luqBtJ0Ur2A79vbUWTMbBYp1DPOqUdXYz7gmefuMwY5jHkPfgnfbYgPfYrrPJrvx8sCGCjhMefAgjtj48fMRFupQCMOeEH1ze4yVCLlieyhNOENcJF7AaYU4uP2LvlrDEkKEIzT54SBli8NjDEXzCnyjbjFyP_hV6YbVP8Pp8XqFfd7c_b75V9z--fr_5cl8ZJmmurOmIAGHGoSkjNnYAw9tmYJxaLhjrDSemk5b01FLByGhby3XXWc4FSGEZu0LvT3WLqz9rsaMml7bB9QxhTaonRDDeiQLyE2hiSCmCVUt0k46PihK1RaQO6hyR2iJSRKoSUdG9PTdYhwnGJ9U5kwK8OwM6Ge1t1LNx6Ynb5qBUFu7ziSuLgqODqJIpizcwulgiVWNw_7HyD26atM8</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Wassmann, Sven</creator><creator>Ribaudo, Nicole</creator><creator>Faul, Anna</creator><creator>Laufs, Ulrich</creator><creator>Böhm, Michael</creator><creator>Nickenig, Georg</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl</title><author>Wassmann, Sven ; Ribaudo, Nicole ; Faul, Anna ; Laufs, Ulrich ; Böhm, Michael ; Nickenig, Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-fc607e7cdb26972fbec542b351f57338c50c69f081f1730df4f5a66f557e97f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Oral</topic><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Atorvastatin</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Heart</topic><topic>Heptanoic Acids - administration & dosage</topic><topic>Heptanoic Acids - pharmacology</topic><topic>Heptanoic Acids - therapeutic use</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Hyperemia - blood</topic><topic>Hyperemia - drug therapy</topic><topic>Hyperemia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitroglycerin - pharmacology</topic><topic>Pulsatile Flow - drug effects</topic><topic>Pyrroles - administration & dosage</topic><topic>Pyrroles - pharmacology</topic><topic>Pyrroles - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wassmann, Sven</creatorcontrib><creatorcontrib>Ribaudo, Nicole</creatorcontrib><creatorcontrib>Faul, Anna</creatorcontrib><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Böhm, Michael</creatorcontrib><creatorcontrib>Nickenig, Georg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wassmann, Sven</au><au>Ribaudo, Nicole</au><au>Faul, Anna</au><au>Laufs, Ulrich</au><au>Böhm, Michael</au><au>Nickenig, Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2004</date><risdate>2004</risdate><volume>93</volume><issue>1</issue><spage>84</spage><epage>88</epage><pages>84-88</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 ± 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14697473</pmid><doi>10.1016/j.amjcard.2003.09.018</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2004, Vol.93 (1), p.84-88 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80073567 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Atorvastatin Biological and medical sciences Blood Flow Velocity - drug effects Brachial Artery - drug effects Brachial Artery - physiology Cardiology. Vascular system Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Double-Blind Method Drug Administration Schedule Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female Forearm - blood supply Heart Heptanoic Acids - administration & dosage Heptanoic Acids - pharmacology Heptanoic Acids - therapeutic use Humans Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - physiopathology Hyperemia - blood Hyperemia - drug therapy Hyperemia - physiopathology Male Medical sciences Middle Aged Nitroglycerin - pharmacology Pulsatile Flow - drug effects Pyrroles - administration & dosage Pyrroles - pharmacology Pyrroles - therapeutic use Treatment Outcome Triglycerides - blood Vasodilation - drug effects Vasodilation - physiology |
| title | Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T11%3A50%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20atorvastatin%2080%20mg%20on%20endothelial%20cell%20function%20(forearm%20blood%20flow)%20in%20patients%20with%20pretreatment%20serum%20low-density%20lipoprotein%20cholesterol%20levels%20%3C130%20mg/dl&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Wassmann,%20Sven&rft.date=2004&rft.volume=93&rft.issue=1&rft.spage=84&rft.epage=88&rft.pages=84-88&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2003.09.018&rft_dat=%3Cproquest_cross%3E80073567%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80073567&rft_id=info:pmid/14697473&rft_els_id=S0002914903013353&rfr_iscdi=true |