HIV-1 Tat protein trans-activates transcription in vitro

Tat protein of human immunodeficiency virus 1 is a potent trans-activator of viral gene expression. We show that purified Tat protein stimulates transcription from viral promoters greater than 10-fold in vitro. A Tat protein mutant that does not trans-activate in vivo did not stimulate transcription...

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Veröffentlicht in:	Cell 1990-11, Vol.63 (4), p.791-802
Hauptverfasser:	Marciniak, Robert A., Calnan, Barbara J., Frankel, Alan D., Sharp, Phillip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cell Nucleus - metabolism Fundamental and applied biological sciences. Psychology Gene Products, tat - metabolism HIV-1 - genetics Microbiology Molecular Sequence Data Nucleic Acid Hybridization Plasmids Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA, Viral - genetics tat Gene Products, Human Immunodeficiency Virus Templates, Genetic Transcription, Genetic Transcriptional Activation Virology
Online-Zugang:	Volltext
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