Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis

We have shown the protection of human central nervous system (CNS) cultures by zinc (Zn) or cadmium (Cd)-pre-induced metallothionein (MT) synthesis from radiation-induced cytotoxicity (lactate dehydrogenase (LDH) release and neuronal dendritic injury). The present study is to further define the type...

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Veröffentlicht in:	Toxicology letters 2004-02, Vol.146 (3), p.217-226
Hauptverfasser:	Cai, Lu, Iskander, Sammy, Cherian, M.George, Hammond, Robert R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant Apoptosis - radiation effects Astrocytes - metabolism Astrocytes - pathology Astrocytes - radiation effects Cadmium - metabolism Cadmium - pharmacology Cell death Central Nervous System - metabolism Central Nervous System - pathology Central Nervous System - radiation effects chemoprotection Coloring Agents - metabolism DNA Fragmentation - radiation effects Fluorescent Antibody Technique Gamma Rays Human astrocytes Humans In Situ Nick-End Labeling L-Lactate Dehydrogenase - metabolism Metallothionein Metallothionein - biosynthesis Metallothionein - metabolism Oxidative stress Primary human CNS Propidium - metabolism Radiation Zinc - metabolism Zinc - pharmacology
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