Increased expression of the multidrug‐resistance gene in undifferentiated sarcoma
We analyzed multidrug‐resistance gene (mdr1 gene) expression in a patient with undifferentiated sarcoma of the liver using the cloned cDNA for the mdr1 gene. Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including do...
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| Veröffentlicht in: | Cancer 1990-11, Vol.66 (9), p.1980-1983 |
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| container_end_page | 1983 |
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| container_issue | 9 |
| container_start_page | 1980 |
| container_title | Cancer |
| container_volume | 66 |
| creator | Tawa, Akio Inoue, Masami Ishihara, Shigehiko Hara, Junichi Yumura‐Yagi, Keiko Okumura, Kenzo Okada, Akira Nihei, Akio Taguchi, Junji Kanai, Nobuhiro Tsuruo, Takashi Kawa‐Ha, Keisei |
| description | We analyzed multidrug‐resistance gene (mdr1 gene) expression in a patient with undifferentiated sarcoma of the liver using the cloned cDNA for the mdr1 gene. Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including doxorubicin and teniposide. The level of mdr1 gene expression was increased sevenfold in the intracranial tumor at the time of first relapse and 11‐fold at the second relapse. This case may be an example of acquired multidrug resistance associated with overexpression of the mdr1 gene. |
| doi_str_mv | 10.1002/1097-0142(19901101)66:9<1980::AID-CNCR2820660922>3.0.CO;2-E |
| format | Article |
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Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including doxorubicin and teniposide. The level of mdr1 gene expression was increased sevenfold in the intracranial tumor at the time of first relapse and 11‐fold at the second relapse. 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Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including doxorubicin and teniposide. The level of mdr1 gene expression was increased sevenfold in the intracranial tumor at the time of first relapse and 11‐fold at the second relapse. This case may be an example of acquired multidrug resistance associated with overexpression of the mdr1 gene.</description><subject>Child, Preschool</subject><subject>Drug Resistance - genetics</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Liver Neoplasms - genetics</subject><subject>Male</subject><subject>Sarcoma - genetics</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN2K1EAQhRtR1nH1EYRciV5krK7OdtKjCEscdWBxwB8QvCh6OpW1JT9jd4LunY_gM_okJsy4oBeCV0VxTp2q-oQoJSwlAD6WYPIUZIYPpTEgJchHWq_MU2kKWK3ON8_T8nX5BgsErcEgPlNLWJbbJ5iub4jF9fRNsQCAIj3L1Ifb4k6Mn6c2xzN1Ik4QMcuNXoi3m84FtpGrhL_tA8fo-y7p62T4xEk7NoOvwnj58_uPSfJxsJ3j5JI7TnyXjF3l65oDd4O3w5QQbXB9a--KW7VtIt871lPx_sX6Xfkqvdi-3JTnF6nLtMGUMzQqcyZDrVXlnEO0GaM0zKpSerfT0jq2GRQajdG5U0Zznbsd5gXURqpT8eCQuw_9l5HjQK2PjpvGdtyPkYrpXQA1Gz8ejC70MQauaR98a8MVSaAZOc3QaIZGv5GT1mRoRk40Iac_kZMioHJLSOsp_f7xjHHXcnWdfWQ86fVB_-obvvq_1f_c_JeifgFpPqAZ</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Tawa, Akio</creator><creator>Inoue, Masami</creator><creator>Ishihara, Shigehiko</creator><creator>Hara, Junichi</creator><creator>Yumura‐Yagi, Keiko</creator><creator>Okumura, Kenzo</creator><creator>Okada, Akira</creator><creator>Nihei, Akio</creator><creator>Taguchi, Junji</creator><creator>Kanai, Nobuhiro</creator><creator>Tsuruo, Takashi</creator><creator>Kawa‐Ha, Keisei</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901101</creationdate><title>Increased expression of the multidrug‐resistance gene in undifferentiated sarcoma</title><author>Tawa, Akio ; Inoue, Masami ; Ishihara, Shigehiko ; Hara, Junichi ; Yumura‐Yagi, Keiko ; Okumura, Kenzo ; Okada, Akira ; Nihei, Akio ; Taguchi, Junji ; Kanai, Nobuhiro ; Tsuruo, Takashi ; Kawa‐Ha, Keisei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4692-e42934c942663dccc22a4e219ee3d36bb61acea408629967c396ef7cb2780f913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Child, Preschool</topic><topic>Drug Resistance - genetics</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Liver Neoplasms - genetics</topic><topic>Male</topic><topic>Sarcoma - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tawa, Akio</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><creatorcontrib>Ishihara, Shigehiko</creatorcontrib><creatorcontrib>Hara, Junichi</creatorcontrib><creatorcontrib>Yumura‐Yagi, Keiko</creatorcontrib><creatorcontrib>Okumura, Kenzo</creatorcontrib><creatorcontrib>Okada, Akira</creatorcontrib><creatorcontrib>Nihei, Akio</creatorcontrib><creatorcontrib>Taguchi, Junji</creatorcontrib><creatorcontrib>Kanai, Nobuhiro</creatorcontrib><creatorcontrib>Tsuruo, Takashi</creatorcontrib><creatorcontrib>Kawa‐Ha, Keisei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tawa, Akio</au><au>Inoue, Masami</au><au>Ishihara, Shigehiko</au><au>Hara, Junichi</au><au>Yumura‐Yagi, Keiko</au><au>Okumura, Kenzo</au><au>Okada, Akira</au><au>Nihei, Akio</au><au>Taguchi, Junji</au><au>Kanai, Nobuhiro</au><au>Tsuruo, Takashi</au><au>Kawa‐Ha, Keisei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of the multidrug‐resistance gene in undifferentiated sarcoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>66</volume><issue>9</issue><spage>1980</spage><epage>1983</epage><pages>1980-1983</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>We analyzed multidrug‐resistance gene (mdr1 gene) expression in a patient with undifferentiated sarcoma of the liver using the cloned cDNA for the mdr1 gene. Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including doxorubicin and teniposide. The level of mdr1 gene expression was increased sevenfold in the intracranial tumor at the time of first relapse and 11‐fold at the second relapse. This case may be an example of acquired multidrug resistance associated with overexpression of the mdr1 gene.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2224796</pmid><doi>10.1002/1097-0142(19901101)66:9<1980::AID-CNCR2820660922>3.0.CO;2-E</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1990-11, Vol.66 (9), p.1980-1983 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80070031 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Child, Preschool Drug Resistance - genetics Gene Expression Humans Immunoblotting Liver Neoplasms - genetics Male Sarcoma - genetics |
| title | Increased expression of the multidrug‐resistance gene in undifferentiated sarcoma |
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