Evidence of GATA‐3‐dependent Th2 commitment during the in vivo immune response

The transcription factor GATA‐3 has been shown to play an important role for the in vitro induction of Th2 cells. To clarify how the in vivo immune response is governed under GATA‐3 function, we generated double‐transgenic mice by crossing GATA‐3 transgenic mice with ovalbumin (OVA)‐specific TCR tra...

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Veröffentlicht in:	International immunology 2004-01, Vol.16 (1), p.179-187
Hauptverfasser:	Tamauchi, Hidekazu, Terashima, Masazumi, Ito, Mamoru, Maruyama, Hiroko, Ikewaki, Nobunao, Inoue, Matsuhisa, Gao, Xiuhua, Hozumi, Katsuto, Habu, Sonoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigen‐specific Ig isotype Bronchoalveolar Lavage Fluid - immunology CD4 Antigens - immunology DNA-Binding Proteins - immunology Flow Cytometry GATA3 Transcription Factor GATA‐3 GATA‐3 transgenic mice Immunoblotting Immunoglobulin A - blood Immunoglobulin E - blood Immunoglobulin G - blood Interleukin-13 - biosynthesis Interleukin-5 - biosynthesis Lymphocyte Activation - immunology Mice Mice, Transgenic Ovalbumin - genetics Ovalbumin - immunology ovalbumin‐specific TCR transgenic mice Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Reverse Transcriptase Polymerase Chain Reaction Th2 Cells - immunology Th2 cytokine Trans-Activators - immunology
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