Redox-Sensing Release of Human Thioredoxin from T Lymphocytes with Negative Feedback Loops

Thioredoxin (TRX) is released from various types of mammalian cells despite no typical secretory signal sequence. We show here that a redox-active site in TRX is essential for its release from T lymphocytes in response to H2O2 and extracellular TRX regulates its own H2O2-induced release. Human T cel...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-01, Vol.172 (1), p.442-448
Hauptverfasser:	Kondo, Norihiko, Ishii, Yasuyuki, Kwon, Yong-Won, Tanito, Masaki, Horita, Hiroyuki, Nishinaka, Yumiko, Nakamura, Hajime, Yodoi, Junji
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Apoptosis - physiology Binding Sites - genetics Binding Sites - physiology Cell Line, Transformed Extracellular Fluid - metabolism Extracellular Fluid - physiology Feedback, Physiological - genetics Feedback, Physiological - physiology Human T-lymphotropic virus 1 - physiology Humans Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology Jurkat Cells Oxidation-Reduction Oxidative Stress - genetics Oxidative Stress - physiology Recombinant Proteins - pharmacology Signal Transduction - genetics Signal Transduction - physiology T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thioredoxins - genetics Thioredoxins - metabolism Transfection
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