Effects of Endothelin on Renal Hemodynamics and Renal Function in Anesthetized Dogs
Porcine endothelin was infused directly into the renal artery of anesthetized dogs to evaluate the renal action of endothelin. Endothelin (0.2 to 5.0 ng/kg/min) elicited a dose-dependent reduction in the renal blood blow with no changes in systemic blood pressure. Endothelin infusion (0.2 ng/kg/min)...
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| Veröffentlicht in: | American journal of hypertension 1990-08, Vol.3 (8-Pt-1), p.632-634 |
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| container_end_page | 634 |
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| container_issue | 8-Pt-1 |
| container_start_page | 632 |
| container_title | American journal of hypertension |
| container_volume | 3 |
| creator | Mxura, K. Yukimura, T. Yamashita, Y. Shichino, K. Shimmen, T. Saito, M. Okumura, M. Imanishi, M. Yamanaka, S. Yamamoto, K. |
| description | Porcine endothelin was infused directly into the renal artery of anesthetized dogs to evaluate the renal action of endothelin. Endothelin (0.2 to 5.0 ng/kg/min) elicited a dose-dependent reduction in the renal blood blow with no changes in systemic blood pressure. Endothelin infusion (0.2 ng/kg/min) decreased the renal blood flow by 30% and urinary sodium excretion by 50% without any changes in the glomerular filtration rate. However, higher doses did reduce glomerular filtration rate. These data suggest that endothelin preferentially constricts efferent arterioles and that endothelin may enhance the renal reabsorption of sodium. Am J Hypertens 1990:3:632-634 |
| doi_str_mv | 10.1093/ajh/3.8.632 |
| format | Article |
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Endothelin (0.2 to 5.0 ng/kg/min) elicited a dose-dependent reduction in the renal blood blow with no changes in systemic blood pressure. Endothelin infusion (0.2 ng/kg/min) decreased the renal blood flow by 30% and urinary sodium excretion by 50% without any changes in the glomerular filtration rate. However, higher doses did reduce glomerular filtration rate. These data suggest that endothelin preferentially constricts efferent arterioles and that endothelin may enhance the renal reabsorption of sodium. 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| fulltext | fulltext |
| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 1990-08, Vol.3 (8-Pt-1), p.632-634 |
| issn | 0895-7061 1941-7225 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Blood Pressure - drug effects Dogs Dose-Response Relationship, Drug Endothelin Endothelins - administration & dosage Endothelins - pharmacology Glomerular Filtration Rate - drug effects hemodynamics Infusions, Intra-Arterial Kidney - blood supply Kidney - drug effects Kidney - physiology Regional Blood Flow - drug effects renal Renal Artery - physiology Sodium - urine vasoconstrictor |
| title | Effects of Endothelin on Renal Hemodynamics and Renal Function in Anesthetized Dogs |
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