In vivo and in vitro effects of aldrin on rat brain synaptosomal Mg2+ and Na+, K+-adenosine triphosphatase

Aldrin, a chlorinated hydrocarbon, inhibited rat brain synaptosomal membrane-bound Na+,K(+)-adenosine triphosphatase (ATPase) and Mg2(+)-ATPase activities under in vivo and in vitro conditions. Na+,K(+)-ATPase was non-competitively inhibited whereas Mg2(+)-ATPase was inhibited uncompetitively. Arrhe...

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Veröffentlicht in:	Biochemical pharmacology 1990-10, Vol.40 (7), p.1449-1456
Hauptverfasser:	CHANDRA, M, PODDAR, M. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldrin - pharmacology Animals Biological and medical sciences Brain - drug effects Brain - enzymology Ca(2+) Mg(2+)-ATPase - antagonists & inhibitors Dose-Response Relationship, Drug In Vitro Techniques Kinetics L-Lactate Dehydrogenase - antagonists & inhibitors Male Medical sciences Membrane Fluidity - drug effects Pesticides, fertilizers and other agrochemicals toxicology Rats Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sonication Synaptosomes - drug effects Temperature Toxicology
Online-Zugang:	Volltext
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