A DNA ligase gene in the copenhagen strain of vaccinia virus is nonessential for viral replication and recombination

Biochemical and genetic analyses have been conducted to determine whether a vaccinia virus open reading frame (orf) with extensive homology to the Saccharomyces cerevisiae DNA ligase gene encodes a functional ligase activity. This orf in HindIII A, designated A50R, is capable of encoding a 552-amino...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1990-11, Vol.179 (1), p.267-275
Hauptverfasser:	Colinas, Robert J., Goebel, Scott J., Davis, Stephen W., Johnson, Gerard P., Norton, Elizabeth K., Paoletti, Enzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromosome Deletion Denmark DNA Ligases - genetics DNA Ligases - metabolism Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Genes, Viral Ligases Molecular Sequence Data Plasmids Recombination, Genetic Restriction Mapping Saccharomyces cerevisiae Sequence Homology, Nucleic Acid Transcription, Genetic vaccinia virus Vaccinia virus - enzymology Vaccinia virus - genetics Vaccinia virus - physiology Vero Cells Viral Structural Proteins - genetics Virus Replication
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