Rapidly Progressive Outer Retinal Necrosis in the Acquired Immunodeficiency Syndrome
Two patients, both seropositive for the human immunodeficiency virus, developed rapidly progressive retinal necrosis associated with a systemic herpes zoster infection. The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and...
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| Veröffentlicht in: | American journal of ophthalmology 1990-10, Vol.110 (4), p.341-348 |
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| container_end_page | 348 |
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| container_issue | 4 |
| container_start_page | 341 |
| container_title | American journal of ophthalmology |
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| creator | Forster, David J. Dugel, Pravin U. Frangieh, George T. Liggett, Peter E. Rao, Narsing A. |
| description | Two patients, both seropositive for the human immunodeficiency virus, developed rapidly progressive retinal necrosis associated with a systemic herpes zoster infection. The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, and polymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. This entity may represent a distinct form of acute retinal necrosis that is seen in immunocompromised individuals. |
| doi_str_mv | 10.1016/S0002-9394(14)77012-6 |
| format | Article |
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The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, and polymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. 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The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, and polymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. This entity may represent a distinct form of acute retinal necrosis that is seen in immunocompromised individuals.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Fluorescein Angiography</subject><subject>Fundus Oculi</subject><subject>Herpes Zoster Ophthalmicus - complications</subject><subject>HIV Seropositivity - complications</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Retina - pathology</subject><subject>Retina - ultrastructure</subject><subject>Retinal Necrosis Syndrome, Acute - complications</subject><subject>Retinal Necrosis Syndrome, Acute - pathology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOHDEQRa2IaBhIPmEkb4LCokNVv9xeRWgUHhIKCMjactvViVE_Brt7pPn7eB6CJSvLqnPLvoexBcIPBCwvngAgTWQm8--YnwsBmCblJzbHSsgEK4lHbP6GHLOTEF7itRS5mLFZmqYgSzFnz4965Wy74Q9--OspBLcmfj-N5Pkjja7XLf9Nxg_BBe56Pv4jfmleJ-fJ8tuum_rBUuOMo95s-NOmt37o6Av73Og20NfDecr-XP16Xt4kd_fXt8vLu8TkIhsTQhR1lmFhswqkhbrKtGmgsRkUYABMXoscrTAgKjJVYWRRxwKy1rpCitFTdrbfu_LD60RhVJ0LhtpW9zRMQVWxb5qn4kMQS5SFgC1Y7MFt5eCpUSvvOu03CkFttauddrV1qjBXO-2qjLnF4YGp7si-pQ6e4_zbYa6D0W3jdW9ceF8uo4VUFpH7uecoals78irs3JKNxs2o7OA--Ml_jG-exQ</recordid><startdate>19901015</startdate><enddate>19901015</enddate><creator>Forster, David J.</creator><creator>Dugel, Pravin U.</creator><creator>Frangieh, George T.</creator><creator>Liggett, Peter E.</creator><creator>Rao, Narsing A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19901015</creationdate><title>Rapidly Progressive Outer Retinal Necrosis in the Acquired Immunodeficiency Syndrome</title><author>Forster, David J. ; Dugel, Pravin U. ; Frangieh, George T. ; Liggett, Peter E. ; Rao, Narsing A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-e117b3315d3809d0b83acf0fd3050c00c4b741d7c078ec85c95b0679baa81e7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Fluorescein Angiography</topic><topic>Fundus Oculi</topic><topic>Herpes Zoster Ophthalmicus - complications</topic><topic>HIV Seropositivity - complications</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Retina - pathology</topic><topic>Retina - ultrastructure</topic><topic>Retinal Necrosis Syndrome, Acute - complications</topic><topic>Retinal Necrosis Syndrome, Acute - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forster, David J.</creatorcontrib><creatorcontrib>Dugel, Pravin U.</creatorcontrib><creatorcontrib>Frangieh, George T.</creatorcontrib><creatorcontrib>Liggett, Peter E.</creatorcontrib><creatorcontrib>Rao, Narsing A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forster, David J.</au><au>Dugel, Pravin U.</au><au>Frangieh, George T.</au><au>Liggett, Peter E.</au><au>Rao, Narsing A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapidly Progressive Outer Retinal Necrosis in the Acquired Immunodeficiency Syndrome</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1990-10-15</date><risdate>1990</risdate><volume>110</volume><issue>4</issue><spage>341</spage><epage>348</epage><pages>341-348</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Two patients, both seropositive for the human immunodeficiency virus, developed rapidly progressive retinal necrosis associated with a systemic herpes zoster infection. The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, and polymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. This entity may represent a distinct form of acute retinal necrosis that is seen in immunocompromised individuals.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2220967</pmid><doi>10.1016/S0002-9394(14)77012-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1990-10, Vol.110 (4), p.341-348 |
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| language | eng |
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| subjects | Acquired Immunodeficiency Syndrome - complications Adult AIDS/HIV Biological and medical sciences Fluorescein Angiography Fundus Oculi Herpes Zoster Ophthalmicus - complications HIV Seropositivity - complications Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Male Medical sciences Microscopy, Electron Retina - pathology Retina - ultrastructure Retinal Necrosis Syndrome, Acute - complications Retinal Necrosis Syndrome, Acute - pathology |
| title | Rapidly Progressive Outer Retinal Necrosis in the Acquired Immunodeficiency Syndrome |
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