Antiischemic Effect of Monophosphoryl Lipid A in Conscious Rabbits with Hypercholesterolemia and Atherosclerosis

We studied whether monophosphoryl lipid A (MLA), an endotoxin derivative, protected the heart from planned ischemia in hypercholesterolemic conscious rabbits. Normal and hypercholesterolemic (8-week exposure to 1.5% cholesterol-enriched diet) conscious rabbits with right ventricular electrode and le...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1998-08, Vol.32 (2), p.206-212
Hauptverfasser:	Szilvássy, Zoltán, Ferdinandy, Péter, Cluff, Christopher W, Elliott, Gary T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Arteriosclerosis - complications Biological and medical sciences Cardiovascular system Electrophysiology Heart - drug effects Heart - physiology Hemodynamics - drug effects Hypercholesterolemia - complications Lipid A - analogs & derivatives Lipid A - pharmacology Male Medical sciences Myocardial Ischemia - complications Myocardial Ischemia - prevention & control Pharmacology. Drug treatments Protective Agents - pharmacology Rabbits
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