Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia
We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-i...
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| Veröffentlicht in: | Southern medical journal (Birmingham, Ala.) Ala.), 1990-10, Vol.83 (10), p.1131-1137 |
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| container_title | Southern medical journal (Birmingham, Ala.) |
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| creator | Neal, G W Balm, T K |
| description | We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 months of diet only (29 subjects) or diet supplemented with 20.4 g of psyllium daily (30 subjects). Unlike women, men had a significant decrease in levels of both TC (-8.0%) and low-density lipoprotein cholesterol (LDL-C) (-10.1%) during the dietary lead-in. Psyllium supplementation resulted in an additional 5.5% reduction in the TC levels as compared to diet alone. Psyllium supplementation combined with dietary lead-in resulted in an overall 17.3% decrease in the TC and a 20.0% decrease in LDL-C for men, with decreases of 7.7% and 11.6%, respectively, for women. Psyllium effectively enhances the cholesterol-lowering effect of the phase I diet. |
| doi_str_mv | 10.1097/00007611-199010000-00005 |
| format | Article |
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Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 months of diet only (29 subjects) or diet supplemented with 20.4 g of psyllium daily (30 subjects). Unlike women, men had a significant decrease in levels of both TC (-8.0%) and low-density lipoprotein cholesterol (LDL-C) (-10.1%) during the dietary lead-in. Psyllium supplementation resulted in an additional 5.5% reduction in the TC levels as compared to diet alone. Psyllium supplementation combined with dietary lead-in resulted in an overall 17.3% decrease in the TC and a 20.0% decrease in LDL-C for men, with decreases of 7.7% and 11.6%, respectively, for women. 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Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 months of diet only (29 subjects) or diet supplemented with 20.4 g of psyllium daily (30 subjects). Unlike women, men had a significant decrease in levels of both TC (-8.0%) and low-density lipoprotein cholesterol (LDL-C) (-10.1%) during the dietary lead-in. Psyllium supplementation resulted in an additional 5.5% reduction in the TC levels as compared to diet alone. Psyllium supplementation combined with dietary lead-in resulted in an overall 17.3% decrease in the TC and a 20.0% decrease in LDL-C for men, with decreases of 7.7% and 11.6%, respectively, for women. Psyllium effectively enhances the cholesterol-lowering effect of the phase I diet.</description><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Disease - prevention & control</subject><subject>Drug Administration Schedule</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - diet therapy</subject><subject>Hypercholesterolemia - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Compliance</subject><subject>Psyllium - administration & dosage</subject><subject>Psyllium - therapeutic use</subject><subject>Sex Factors</subject><subject>Stimulation, Chemical</subject><subject>Time Factors</subject><subject>Weight Loss - drug effects</subject><issn>0038-4348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlOwzAQ9QFUSuETkHziFrDjeMkRVWwSEkjAOXLsCTXKhu0c8vc4tHRGmtGM3pvlIYQpuaGklLckmRSUZrQsCV2qbAn8BK0JYSorWKHO0HkI3wuQK7FCqzynSnCyRm_vcw_-y4XoDIamARMDHho8hrlt3dRh1-O4A2wdRO1nHD3o2EEfF9BuHsGb3dBCiOBT6py-QKeNbgNcHvIGfT7cf2yfspfXx-ft3UtmGCUxs7mFwjDLrNJNcl4zS6QxRS25YLYUVOqCMS4gFxqamhJQeSlrLSXXEjTboOv93NEPP1M6oOpcMNC2uodhCpUiRJC0KgHVHmj8EIKHphq969IvFSXVImD1L2B1FPCvxRP16rBjqjuwR-JBPfYLA8NvYw</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Neal, G W</creator><creator>Balm, T K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901001</creationdate><title>Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia</title><author>Neal, G W ; Balm, T K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-d2de4c3d3d8afafa5b3d07cc4b7563d9617a43356e26aefb10e8297ba775a7ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Disease - prevention & control</topic><topic>Drug Administration Schedule</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Food, Fortified</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - diet therapy</topic><topic>Hypercholesterolemia - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Compliance</topic><topic>Psyllium - administration & dosage</topic><topic>Psyllium - therapeutic use</topic><topic>Sex Factors</topic><topic>Stimulation, Chemical</topic><topic>Time Factors</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neal, G W</creatorcontrib><creatorcontrib>Balm, T K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neal, G W</au><au>Balm, T K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia</atitle><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle><addtitle>South Med J</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>83</volume><issue>10</issue><spage>1131</spage><epage>1137</epage><pages>1131-1137</pages><issn>0038-4348</issn><abstract>We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 months of diet only (29 subjects) or diet supplemented with 20.4 g of psyllium daily (30 subjects). Unlike women, men had a significant decrease in levels of both TC (-8.0%) and low-density lipoprotein cholesterol (LDL-C) (-10.1%) during the dietary lead-in. Psyllium supplementation resulted in an additional 5.5% reduction in the TC levels as compared to diet alone. Psyllium supplementation combined with dietary lead-in resulted in an overall 17.3% decrease in the TC and a 20.0% decrease in LDL-C for men, with decreases of 7.7% and 11.6%, respectively, for women. Psyllium effectively enhances the cholesterol-lowering effect of the phase I diet.</abstract><cop>United States</cop><pmid>2218650</pmid><doi>10.1097/00007611-199010000-00005</doi><tpages>7</tpages></addata></record> |
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| ispartof | Southern medical journal (Birmingham, Ala.), 1990-10, Vol.83 (10), p.1131-1137 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Cholesterol - blood Cholesterol, LDL - blood Coronary Disease - prevention & control Drug Administration Schedule Evaluation Studies as Topic Female Food, Fortified Humans Hypercholesterolemia - blood Hypercholesterolemia - diet therapy Hypercholesterolemia - metabolism Male Middle Aged Patient Compliance Psyllium - administration & dosage Psyllium - therapeutic use Sex Factors Stimulation, Chemical Time Factors Weight Loss - drug effects |
| title | Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia |
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