Lipoprotein composition and serum apolipoproteins in normoglycaemic first-degree relatives of non-insulin dependent diabetic patients
Cardiovascular disease is the leading cause of death in non-insulin dependent diabetes mellitus and first degree relatives of such patients are at increased risk of developing diabetes and cardiovascular disease. The aim of the present study was to determine whether lipid abnormalities occur in norm...
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| Veröffentlicht in: | Atherosclerosis 1998-07, Vol.139 (1), p.115-121 |
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| creator | Stewart, M.W Humphriss, D.B Mitcheson, J Webster, J Walker, M Laker, M.F |
| description | Cardiovascular disease is the leading cause of death in non-insulin dependent diabetes mellitus and first degree relatives of such patients are at increased risk of developing diabetes and cardiovascular disease. The aim of the present study was to determine whether lipid abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients. Cholesterol, triglycerides, apolipoprotein A-I and apolipoprotein B concentrations were measured in serum; the lipoprotein fractions very low density, intermediate density, low density and high density lipoprotein were prepared by sequential flotation ultracentrifugation and their composition investigated. The groups were matched for age, sex and blood glucose concentrations although the relatives (
n=126) were more insulin resistant as determined using the homeostasis model assessment method [1.9 (0.8–9.0) vs 1.6 (0.4–4.9) mmol/mU per l (mean {95% confidence intervals});
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| doi_str_mv | 10.1016/S0021-9150(98)00065-3 |
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n=126) were more insulin resistant as determined using the homeostasis model assessment method [1.9 (0.8–9.0) vs 1.6 (0.4–4.9) mmol/mU per l (mean {95% confidence intervals});
p<0.001] and had greater body mass indices [26.6 (4.1) vs 24.8 (3.9) (mean {S.D.});
p=0.001] than control subjects (
n=126). Relatives had higher serum apolipoprotein B concentrations than control subjects [0.9 (0.3) vs 0.8 (0.3) g/l,
p=0.02) and lower serum apolipoprotein A-I concentrations (1.4 (0.3) vs 1.5 (0.3),
p=0.02). In multivariate linear regression analysis of all subjects log insulin resistance (
p=0.0001), age (
p=0.002) and waist:hip ratio (
p=0.01) were independent predicators of apolipoprotein B concentrations while waist:hip ratio (
p<0.001) and smoking status (
p=0.002) were independent predictors of apolipoprotein A-I concentrations. Lipoprotein composition (measured in a subgroup of 76 control subjects and 88 relatives), serum cholesterol and serum triglyceride concentrations did not differ between the groups. We conclude that atherogenic apolipoprotein abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(98)00065-3</identifier><identifier>PMID: 9699898</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adult ; Apolipoprotein A-I ; Apolipoprotein A-I - blood ; Apolipoprotein B ; Apolipoproteins - blood ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Nonesterified - blood ; Female ; Humans ; Insulin - blood ; lipids ; Lipoprotein composition ; Male ; Medical sciences ; Non-insulin dependent diabetes mellitus ; Normoglycaemia ; Relatives</subject><ispartof>Atherosclerosis, 1998-07, Vol.139 (1), p.115-121</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f464557dedae596ace66fbb5ef77db65c9975ddc9b7f9a597e929d73b5da19a83</citedby><cites>FETCH-LOGICAL-c389t-f464557dedae596ace66fbb5ef77db65c9975ddc9b7f9a597e929d73b5da19a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9150(98)00065-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2338619$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9699898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stewart, M.W</creatorcontrib><creatorcontrib>Humphriss, D.B</creatorcontrib><creatorcontrib>Mitcheson, J</creatorcontrib><creatorcontrib>Webster, J</creatorcontrib><creatorcontrib>Walker, M</creatorcontrib><creatorcontrib>Laker, M.F</creatorcontrib><title>Lipoprotein composition and serum apolipoproteins in normoglycaemic first-degree relatives of non-insulin dependent diabetic patients</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Cardiovascular disease is the leading cause of death in non-insulin dependent diabetes mellitus and first degree relatives of such patients are at increased risk of developing diabetes and cardiovascular disease. The aim of the present study was to determine whether lipid abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients. Cholesterol, triglycerides, apolipoprotein A-I and apolipoprotein B concentrations were measured in serum; the lipoprotein fractions very low density, intermediate density, low density and high density lipoprotein were prepared by sequential flotation ultracentrifugation and their composition investigated. The groups were matched for age, sex and blood glucose concentrations although the relatives (
n=126) were more insulin resistant as determined using the homeostasis model assessment method [1.9 (0.8–9.0) vs 1.6 (0.4–4.9) mmol/mU per l (mean {95% confidence intervals});
p<0.001] and had greater body mass indices [26.6 (4.1) vs 24.8 (3.9) (mean {S.D.});
p=0.001] than control subjects (
n=126). Relatives had higher serum apolipoprotein B concentrations than control subjects [0.9 (0.3) vs 0.8 (0.3) g/l,
p=0.02) and lower serum apolipoprotein A-I concentrations (1.4 (0.3) vs 1.5 (0.3),
p=0.02). In multivariate linear regression analysis of all subjects log insulin resistance (
p=0.0001), age (
p=0.002) and waist:hip ratio (
p=0.01) were independent predicators of apolipoprotein B concentrations while waist:hip ratio (
p<0.001) and smoking status (
p=0.002) were independent predictors of apolipoprotein A-I concentrations. Lipoprotein composition (measured in a subgroup of 76 control subjects and 88 relatives), serum cholesterol and serum triglyceride concentrations did not differ between the groups. We conclude that atherogenic apolipoprotein abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients.</description><subject>Adult</subject><subject>Apolipoprotein A-I</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoprotein B</subject><subject>Apolipoproteins - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>lipids</subject><subject>Lipoprotein composition</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non-insulin dependent diabetes mellitus</subject><subject>Normoglycaemia</subject><subject>Relatives</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67j6ExZyENFDazLd-aiTyOIXDHhQzyGdVJZId6dN0gv7A_zfZneG8eipIPW8VZWHkCvO3nLG5bvvjO15B1yw16DfMMak6PpHZMe1go4PenhMdmfkKXlWyq8GDYrrC3IBEkCD3pE_h7imNaeKcaEuzWsqsca0ULt4WjBvM7Vrmv5BhTZwSXlON9OdszhHR0PMpXYebzIizTjZGm-x0BQauHQts00t5HHFxeNSqY92xNqCayPbQ3lOngQ7FXxxqpfk56ePP66_dIdvn79efzh0rtdQuzDIQQjl0VsUIK1DKcM4CgxK-VEKB6CE9w5GFcAKUAh78KofhbccrO4vyavj3PaZ3xuWauZYHE6TXTBtxWjG2lwmGyiOoMuplIzBrDnONt8Zzsy9fvOg39y7NaDNg37Tt9zVacE2zujPqZPv1n956tvi7BSyXVwsZ2zf91pyaNj7I4ZNxm3EbIprohz6mNFV41P8zyF_Aerkppo</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Stewart, M.W</creator><creator>Humphriss, D.B</creator><creator>Mitcheson, J</creator><creator>Webster, J</creator><creator>Walker, M</creator><creator>Laker, M.F</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Lipoprotein composition and serum apolipoproteins in normoglycaemic first-degree relatives of non-insulin dependent diabetic patients</title><author>Stewart, M.W ; Humphriss, D.B ; Mitcheson, J ; Webster, J ; Walker, M ; Laker, M.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-f464557dedae596ace66fbb5ef77db65c9975ddc9b7f9a597e929d73b5da19a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Apolipoprotein A-I</topic><topic>Apolipoprotein A-I - blood</topic><topic>Apolipoprotein B</topic><topic>Apolipoproteins - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>lipids</topic><topic>Lipoprotein composition</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non-insulin dependent diabetes mellitus</topic><topic>Normoglycaemia</topic><topic>Relatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stewart, M.W</creatorcontrib><creatorcontrib>Humphriss, D.B</creatorcontrib><creatorcontrib>Mitcheson, J</creatorcontrib><creatorcontrib>Webster, J</creatorcontrib><creatorcontrib>Walker, M</creatorcontrib><creatorcontrib>Laker, M.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stewart, M.W</au><au>Humphriss, D.B</au><au>Mitcheson, J</au><au>Webster, J</au><au>Walker, M</au><au>Laker, M.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein composition and serum apolipoproteins in normoglycaemic first-degree relatives of non-insulin dependent diabetic patients</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>139</volume><issue>1</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Cardiovascular disease is the leading cause of death in non-insulin dependent diabetes mellitus and first degree relatives of such patients are at increased risk of developing diabetes and cardiovascular disease. The aim of the present study was to determine whether lipid abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients. Cholesterol, triglycerides, apolipoprotein A-I and apolipoprotein B concentrations were measured in serum; the lipoprotein fractions very low density, intermediate density, low density and high density lipoprotein were prepared by sequential flotation ultracentrifugation and their composition investigated. The groups were matched for age, sex and blood glucose concentrations although the relatives (
n=126) were more insulin resistant as determined using the homeostasis model assessment method [1.9 (0.8–9.0) vs 1.6 (0.4–4.9) mmol/mU per l (mean {95% confidence intervals});
p<0.001] and had greater body mass indices [26.6 (4.1) vs 24.8 (3.9) (mean {S.D.});
p=0.001] than control subjects (
n=126). Relatives had higher serum apolipoprotein B concentrations than control subjects [0.9 (0.3) vs 0.8 (0.3) g/l,
p=0.02) and lower serum apolipoprotein A-I concentrations (1.4 (0.3) vs 1.5 (0.3),
p=0.02). In multivariate linear regression analysis of all subjects log insulin resistance (
p=0.0001), age (
p=0.002) and waist:hip ratio (
p=0.01) were independent predicators of apolipoprotein B concentrations while waist:hip ratio (
p<0.001) and smoking status (
p=0.002) were independent predictors of apolipoprotein A-I concentrations. Lipoprotein composition (measured in a subgroup of 76 control subjects and 88 relatives), serum cholesterol and serum triglyceride concentrations did not differ between the groups. We conclude that atherogenic apolipoprotein abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic patients.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9699898</pmid><doi>10.1016/S0021-9150(98)00065-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Atherosclerosis, 1998-07, Vol.139 (1), p.115-121 |
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| subjects | Adult Apolipoprotein A-I Apolipoprotein A-I - blood Apolipoprotein B Apolipoproteins - blood Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Female Humans Insulin - blood lipids Lipoprotein composition Male Medical sciences Non-insulin dependent diabetes mellitus Normoglycaemia Relatives |
| title | Lipoprotein composition and serum apolipoproteins in normoglycaemic first-degree relatives of non-insulin dependent diabetic patients |
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