Electrophysiological and behavioral effects of Tyr- d-Arg-Phe-Sar on locus coeruleus neurons of the rat

The effect of Tyr- d-Arg-Phe-Sar (TAPS), a μ-selective tetrapeptide analog of dermorphin, was studied in the rat both in vitro, using slices of the locus coeruleus, and in vivo, after microinjection into the locus coeruleus. In electrophysiological studies, TAPS (1–100 nM) was able to inhibit sponta...

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Veröffentlicht in:	European journal of pharmacology 1998-06, Vol.351 (1), p.23-30
Hauptverfasser:	Yang, Yea-Ru, Lee, Eminy H.Y, Chiu, Tsai-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Analgesics - pharmacology Animals Biological and medical sciences Dose-Response Relationship, Drug Electrophysiology Hypnotics and Sedatives - pharmacology Injections, Intraventricular Intracellular recording Locomotor activity Locus coeruleus Locus Coeruleus - drug effects Male Medical sciences Membrane Potentials - drug effects Motor Activity - drug effects Neurons - drug effects Neurons - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oligopeptides - administration & dosage Oligopeptides - antagonists & inhibitors Oligopeptides - pharmacology Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Potassium Channels - drug effects Rats Rats, Sprague-Dawley Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Tyr- d-Arg-Phe-Sar
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