Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to γ-radiation and premature senescence

The putative Brca2-MmRad51 interaction is analyzed in mouse cells deleted for the COOH terminus of Brca2 (amino acids 3140-3328), which contains a region that associates with MmRad51 by yeast two-hybrid. These cells are hypersensitive to gamma-radiation (suggesting defective recombinational repair)...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-08, Vol.58 (15), p.3441-3447
Hauptverfasser:	MORIMATSU, M, DONOHO, G, HASTY, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Biological and medical sciences BRCA2 Protein Cell Division - physiology Cell physiology Cellular Senescence - physiology Cellular Senescence - radiation effects DNA Damage DNA Repair DNA-Binding Proteins - metabolism Exons Fibroblasts - cytology Fibroblasts - physiology Fibroblasts - radiation effects Fundamental and applied biological sciences. Psychology Gamma Rays Gene Deletion Gene Targeting Mice Molecular and cellular biology Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Radiation Tolerance - physiology Transcription Factors - genetics Transcription Factors - metabolism
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