Five SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin (SMARC) Genes Are Dispersed in the Human Genome

The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes toregions on four different human chromosomes,SMARCC1to 3p23–p21,SMARCC2to 12q13–q14,SMARCD1to 12q13–q14,SMARCD2to 17q23–q24, andSMARCD3to 7q35–q36.SMARCC1,SMARCC2,andSMARCD1are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers.SMARCD1was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied.