Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue
β-Lipotropin, a pituitary peptide, is a potent stimulator of lipolysis in rabbit adipose tissue in vitro and in vivo. Insulin inhibited the β-lipotropin (1–100 nM)-stimulated glycerol release from rabbit adipocytes and fat pads significantly at concentrations of 10 and 100 μM. Both these concentrati...
Gespeichert in:
| Veröffentlicht in: | Regulatory peptides 1990-07, Vol.29 (2), p.257-266 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 266 |
|---|---|
| container_issue | 2 |
| container_start_page | 257 |
| container_title | Regulatory peptides |
| container_volume | 29 |
| creator | Richter, Werner O. Jacob, Bernd G. Schwandt, Peter |
| description | β-Lipotropin, a pituitary peptide, is a potent stimulator of lipolysis in rabbit adipose tissue in vitro and in vivo. Insulin inhibited the β-lipotropin (1–100 nM)-stimulated glycerol release from rabbit adipocytes and fat pads significantly at concentrations of 10 and 100 μM. Both these concentrations of insulin also decreased the degradation of β-lipotropin in intact adipose tissue to the same extent as the lipolytic activity. Furthermore, insulin reduced the degradation of β-lipotropin in rabbit adipose tissue homogenate. Like insulin, several lysosomotropic agents also decreased significantly the degradation and the lipolytic activity of β-lipotropin. On the other hand, insulin-like growth factor I in lower concentrations (1–100 nM) did not effect degradation and lipolytic activity of β-lipotropin in rabbit adipose tissue. Thus, a direct influence of insulin on lysosomal enzymes degrading β-lipotropin in rabbit adipose tissue can be suggested. |
| doi_str_mv | 10.1016/0167-0115(90)90088-E |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80057634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>016701159090088E</els_id><sourcerecordid>80057634</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-b69b1f961bf00d361288845e4064255bcb4b6e7035593ac3f50d53fb01eedc7d3</originalsourceid><addsrcrecordid>eNp9kMtq3DAUhkVpSSdp36ABbVqShdMjy7p4EyhhcoFANsmyCF2OWwWPPZXkwLxWHqTPVE9mSHZdHATnfP-P-Aj5wuCMAZPf51EVMCZOWjhtAbSulu_IgmnFKya1fE8Wr8hHcpjzIwATSvEDclDXTLUgFuTnzZCnPg40Dr-jiyXTPq7HflOip9aX-BTLhtoh0IC_kg22xHGgY0f_PldbsKRx_RKmybo5Tm2YtxlpiTlP-Il86Gyf8fP-PSIPl8v7i-vq9u7q5uLHbeW5VqVysnWsayVzHUDgktVa60ZgA7KphXDeNU6iAi5Ey63nnYAgeOeAIQavAj8i33a96zT-mTAXs4rZY9_bAccpGw0glOTNDDY70Kcx54SdWae4smljGJitVbNVZrbKTAvmxapZzrHjff_kVhheQ3uN8_3r_m6zt32X7OBjfutua8VYo2fufMfhLOMpYjLZRxw8hpjQFxPG-P-P_ANUEZT3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80057634</pqid></control><display><type>article</type><title>Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Richter, Werner O. ; Jacob, Bernd G. ; Schwandt, Peter</creator><creatorcontrib>Richter, Werner O. ; Jacob, Bernd G. ; Schwandt, Peter</creatorcontrib><description>β-Lipotropin, a pituitary peptide, is a potent stimulator of lipolysis in rabbit adipose tissue in vitro and in vivo. Insulin inhibited the β-lipotropin (1–100 nM)-stimulated glycerol release from rabbit adipocytes and fat pads significantly at concentrations of 10 and 100 μM. Both these concentrations of insulin also decreased the degradation of β-lipotropin in intact adipose tissue to the same extent as the lipolytic activity. Furthermore, insulin reduced the degradation of β-lipotropin in rabbit adipose tissue homogenate. Like insulin, several lysosomotropic agents also decreased significantly the degradation and the lipolytic activity of β-lipotropin. On the other hand, insulin-like growth factor I in lower concentrations (1–100 nM) did not effect degradation and lipolytic activity of β-lipotropin in rabbit adipose tissue. Thus, a direct influence of insulin on lysosomal enzymes degrading β-lipotropin in rabbit adipose tissue can be suggested.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(90)90088-E</identifier><identifier>PMID: 2217905</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adipose tissue ; Adipose Tissue - cytology ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; beta-Lipotropin - metabolism ; beta-Lipotropin - pharmacology ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions ; Glycerol - metabolism ; In Vitro Techniques ; Insulin ; Insulin - pharmacology ; Insulin-Like Growth Factor I - pharmacology ; Lipolysis - drug effects ; Lipolytic activity ; Rabbit ; Rabbits ; Stimulation, Chemical ; Vertebrates: endocrinology</subject><ispartof>Regulatory peptides, 1990-07, Vol.29 (2), p.257-266</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-b69b1f961bf00d361288845e4064255bcb4b6e7035593ac3f50d53fb01eedc7d3</citedby><cites>FETCH-LOGICAL-c387t-b69b1f961bf00d361288845e4064255bcb4b6e7035593ac3f50d53fb01eedc7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016701159090088E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19271148$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2217905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richter, Werner O.</creatorcontrib><creatorcontrib>Jacob, Bernd G.</creatorcontrib><creatorcontrib>Schwandt, Peter</creatorcontrib><title>Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>β-Lipotropin, a pituitary peptide, is a potent stimulator of lipolysis in rabbit adipose tissue in vitro and in vivo. Insulin inhibited the β-lipotropin (1–100 nM)-stimulated glycerol release from rabbit adipocytes and fat pads significantly at concentrations of 10 and 100 μM. Both these concentrations of insulin also decreased the degradation of β-lipotropin in intact adipose tissue to the same extent as the lipolytic activity. Furthermore, insulin reduced the degradation of β-lipotropin in rabbit adipose tissue homogenate. Like insulin, several lysosomotropic agents also decreased significantly the degradation and the lipolytic activity of β-lipotropin. On the other hand, insulin-like growth factor I in lower concentrations (1–100 nM) did not effect degradation and lipolytic activity of β-lipotropin in rabbit adipose tissue. Thus, a direct influence of insulin on lysosomal enzymes degrading β-lipotropin in rabbit adipose tissue can be suggested.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>beta-Lipotropin - metabolism</subject><subject>beta-Lipotropin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions</subject><subject>Glycerol - metabolism</subject><subject>In Vitro Techniques</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin-Like Growth Factor I - pharmacology</subject><subject>Lipolysis - drug effects</subject><subject>Lipolytic activity</subject><subject>Rabbit</subject><subject>Rabbits</subject><subject>Stimulation, Chemical</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtq3DAUhkVpSSdp36ABbVqShdMjy7p4EyhhcoFANsmyCF2OWwWPPZXkwLxWHqTPVE9mSHZdHATnfP-P-Aj5wuCMAZPf51EVMCZOWjhtAbSulu_IgmnFKya1fE8Wr8hHcpjzIwATSvEDclDXTLUgFuTnzZCnPg40Dr-jiyXTPq7HflOip9aX-BTLhtoh0IC_kg22xHGgY0f_PldbsKRx_RKmybo5Tm2YtxlpiTlP-Il86Gyf8fP-PSIPl8v7i-vq9u7q5uLHbeW5VqVysnWsayVzHUDgktVa60ZgA7KphXDeNU6iAi5Ey63nnYAgeOeAIQavAj8i33a96zT-mTAXs4rZY9_bAccpGw0glOTNDDY70Kcx54SdWae4smljGJitVbNVZrbKTAvmxapZzrHjff_kVhheQ3uN8_3r_m6zt32X7OBjfutua8VYo2fufMfhLOMpYjLZRxw8hpjQFxPG-P-P_ANUEZT3</recordid><startdate>19900730</startdate><enddate>19900730</enddate><creator>Richter, Werner O.</creator><creator>Jacob, Bernd G.</creator><creator>Schwandt, Peter</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900730</creationdate><title>Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue</title><author>Richter, Werner O. ; Jacob, Bernd G. ; Schwandt, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-b69b1f961bf00d361288845e4064255bcb4b6e7035593ac3f50d53fb01eedc7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - cytology</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>beta-Lipotropin - metabolism</topic><topic>beta-Lipotropin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions</topic><topic>Glycerol - metabolism</topic><topic>In Vitro Techniques</topic><topic>Insulin</topic><topic>Insulin - pharmacology</topic><topic>Insulin-Like Growth Factor I - pharmacology</topic><topic>Lipolysis - drug effects</topic><topic>Lipolytic activity</topic><topic>Rabbit</topic><topic>Rabbits</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richter, Werner O.</creatorcontrib><creatorcontrib>Jacob, Bernd G.</creatorcontrib><creatorcontrib>Schwandt, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richter, Werner O.</au><au>Jacob, Bernd G.</au><au>Schwandt, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1990-07-30</date><risdate>1990</risdate><volume>29</volume><issue>2</issue><spage>257</spage><epage>266</epage><pages>257-266</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>β-Lipotropin, a pituitary peptide, is a potent stimulator of lipolysis in rabbit adipose tissue in vitro and in vivo. Insulin inhibited the β-lipotropin (1–100 nM)-stimulated glycerol release from rabbit adipocytes and fat pads significantly at concentrations of 10 and 100 μM. Both these concentrations of insulin also decreased the degradation of β-lipotropin in intact adipose tissue to the same extent as the lipolytic activity. Furthermore, insulin reduced the degradation of β-lipotropin in rabbit adipose tissue homogenate. Like insulin, several lysosomotropic agents also decreased significantly the degradation and the lipolytic activity of β-lipotropin. On the other hand, insulin-like growth factor I in lower concentrations (1–100 nM) did not effect degradation and lipolytic activity of β-lipotropin in rabbit adipose tissue. Thus, a direct influence of insulin on lysosomal enzymes degrading β-lipotropin in rabbit adipose tissue can be suggested.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2217905</pmid><doi>10.1016/0167-0115(90)90088-E</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-0115 |
| ispartof | Regulatory peptides, 1990-07, Vol.29 (2), p.257-266 |
| issn | 0167-0115 1873-1686 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80057634 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adipose tissue Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Animals beta-Lipotropin - metabolism beta-Lipotropin - pharmacology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Glycerol - metabolism In Vitro Techniques Insulin Insulin - pharmacology Insulin-Like Growth Factor I - pharmacology Lipolysis - drug effects Lipolytic activity Rabbit Rabbits Stimulation, Chemical Vertebrates: endocrinology |
| title | Insulin inhibits lipolytic activity and degradation of β-lipotropin in rabbit adipose tissue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T18%3A40%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin%20inhibits%20lipolytic%20activity%20and%20degradation%20of%20%CE%B2-lipotropin%20in%20rabbit%20adipose%20tissue&rft.jtitle=Regulatory%20peptides&rft.au=Richter,%20Werner%20O.&rft.date=1990-07-30&rft.volume=29&rft.issue=2&rft.spage=257&rft.epage=266&rft.pages=257-266&rft.issn=0167-0115&rft.eissn=1873-1686&rft.coden=REPPDY&rft_id=info:doi/10.1016/0167-0115(90)90088-E&rft_dat=%3Cproquest_cross%3E80057634%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80057634&rft_id=info:pmid/2217905&rft_els_id=016701159090088E&rfr_iscdi=true |