Notch Receptor Activation Inhibits Oligodendrocyte Differentiation

In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notc...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1998-07, Vol.21 (1), p.63-75
Hauptverfasser:	Wang, Songli, Sdrulla, Andrei D, diSibio, Guy, Bush, Gay, Nofziger, Donna, Hicks, Carol, Weinmaster, Gerry, Barres, Ben A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - growth & development Calcium-Binding Proteins Cell Differentiation - physiology Cells, Cultured Cellular Senescence - physiology Coculture Techniques Humans Intercellular Signaling Peptides and Proteins Jagged-1 Protein Ligands Membrane Proteins - genetics Membrane Proteins - physiology Notch protein Oligodendroglia - cytology Optic Nerve - cytology Optic Nerve - growth & development Optic Nerve - metabolism Proteins - genetics Proteins - metabolism Rats Rats, Sprague-Dawley Receptors, Cell Surface - physiology Receptors, Notch Retina - cytology Retina - growth & development Retina - metabolism RNA, Messenger - metabolism Serrate-Jagged Proteins
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