l-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study
Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of l-dihydroxyphenylalanine ( l-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine...
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| Veröffentlicht in: | Life sciences (1973) 1998-06, Vol.63 (4), p.PL59-PL64 |
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| container_title | Life sciences (1973) |
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| creator | Kashihara, Kenichi Sakai, Kenichi Marui, Konosuke Shohmori, Toshikiyo |
| description | Using
in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of
l-dihydroxyphenylalanine (
l-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of
l-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of
l-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra. |
| doi_str_mv | 10.1016/S0024-3205(98)00275-6 |
| format | Article |
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in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of
l-dihydroxyphenylalanine (
l-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of
l-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of
l-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00275-6</identifier><identifier>PMID: 9698040</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Animals ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Dopamine - metabolism ; Extracellular Space - metabolism ; L-dopa ; Levodopa - pharmacology ; Male ; Microdialysis ; nitric oxide ; Nitric Oxide - biosynthesis ; Nitric Oxide - metabolism ; Rats ; Rats, Sprague-Dawley ; striatum ; substantia nigra ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism</subject><ispartof>Life sciences (1973), 1998-06, Vol.63 (4), p.PL59-PL64</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-558fa1fb8ddca26288a94c99f4439a4868b54d8af8a3a6dbd676ec31d3d37fa33</citedby><cites>FETCH-LOGICAL-c391t-558fa1fb8ddca26288a94c99f4439a4868b54d8af8a3a6dbd676ec31d3d37fa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(98)00275-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9698040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashihara, Kenichi</creatorcontrib><creatorcontrib>Sakai, Kenichi</creatorcontrib><creatorcontrib>Marui, Konosuke</creatorcontrib><creatorcontrib>Shohmori, Toshikiyo</creatorcontrib><title>l-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Using
in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of
l-dihydroxyphenylalanine (
l-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of
l-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of
l-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Extracellular Space - metabolism</subject><subject>L-dopa</subject><subject>Levodopa - pharmacology</subject><subject>Male</subject><subject>Microdialysis</subject><subject>nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>striatum</subject><subject>substantia nigra</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKtvCT6jkE4JDwI4dx-aCqkKhUqUiAWdrYjswKHGK7ay6_x5vd9VrT6PRfG9G8x4h55y954yrDz8Ya2UjWta9NfpdbfquUc_IhuveNEwJ_pxsHpGX5DTnv4yxruvFCTkxymgm2YbcT83n2-8X1C8h07gUOoLDCQuUQCOWhI4u9-gDvUuLX13BJVKMtPwJNEGhuRJQ1plC9DSvQy4QC0KV_k7wkV5HusXtQmd0VY4w7TLmKlr97hV5McKUw-tjPSO_rr78vPzW3Nx-vb68uGmcMLw0XadH4OOgvXfQqlZrMNIZM0opDEit9NBJr2HUIED5wateBSe4F170IwhxRt4c9tYH_q0hFztjdmGaIIZlzVZXTxST7ZMgV1LyvlcV7A5g_SnnFEZ7l3CGtLOc2X009iEau_fdGm0forF73fnxwDrMwT-qjlnU-afDPFQ7thiSzQ5DdMFjCq5Yv-ATF_4DkxWfqg</recordid><startdate>19980619</startdate><enddate>19980619</enddate><creator>Kashihara, Kenichi</creator><creator>Sakai, Kenichi</creator><creator>Marui, Konosuke</creator><creator>Shohmori, Toshikiyo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980619</creationdate><title>l-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study</title><author>Kashihara, Kenichi ; Sakai, Kenichi ; Marui, Konosuke ; Shohmori, Toshikiyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-558fa1fb8ddca26288a94c99f4439a4868b54d8af8a3a6dbd676ec31d3d37fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Extracellular Space - metabolism</topic><topic>L-dopa</topic><topic>Levodopa - pharmacology</topic><topic>Male</topic><topic>Microdialysis</topic><topic>nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>striatum</topic><topic>substantia nigra</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashihara, Kenichi</creatorcontrib><creatorcontrib>Sakai, Kenichi</creatorcontrib><creatorcontrib>Marui, Konosuke</creatorcontrib><creatorcontrib>Shohmori, Toshikiyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashihara, Kenichi</au><au>Sakai, Kenichi</au><au>Marui, Konosuke</au><au>Shohmori, Toshikiyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>l-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998-06-19</date><risdate>1998</risdate><volume>63</volume><issue>4</issue><spage>PL59</spage><epage>PL64</epage><pages>PL59-PL64</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Using
in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of
l-dihydroxyphenylalanine (
l-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of
l-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of
l-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9698040</pmid><doi>10.1016/S0024-3205(98)00275-6</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Extracellular Space - metabolism L-dopa Levodopa - pharmacology Male Microdialysis nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - metabolism Rats Rats, Sprague-Dawley striatum substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism |
| title | l-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study |
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