Early Prognostic Indicators in Primary Perinatal Human Immunodeficiency Virus Type 1 Infection: Importance of Viral RNA and the Timing of Transmission on Long-Term Outcome
The time of perinatal human immunodeficiency virus type 1 (HIV-1) transmission and the pattern of early plasma viremia as predictors of disease progression were evaluated in infected infants followed from birth. Cox proportional hazards modeling demonstrated that a 1-log higher HIV-1 RNA copy number...
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| Veröffentlicht in: | The Journal of infectious diseases 1998-08, Vol.178 (2), p.375-387 |
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| creator | Dickover, Ruth E. Dillon, Maryanne Leung, Kwan-Moon Krogstad, Paul Plaeger, Susan Kwok, Shirley Christopherson, Cindy Deveikis, Audra Keller, Margaret Stiehm, E. Richard Bryson, Yvonne J. |
| description | The time of perinatal human immunodeficiency virus type 1 (HIV-1) transmission and the pattern of early plasma viremia as predictors of disease progression were evaluated in infected infants followed from birth. Cox proportional hazards modeling demonstrated that a 1-log higher HIV-1 RNA copy number at birth was associated with a 40% increase in the relative hazard (RH) of developing CDC class A or B symptoms (P = .004), a 60% increase in developing AIDS (P = .01), and an 80% increase in the of risk death (P = .023) over the follow-up period of up to 8 years. the peak HIV-1 RNA copy number for infants during primary viremia was also predictive of progression to AIDS (RH, 9.9; 95% confidence interval [95% CI], 1.8–54.1; P = .008) and death (RH, 6.9; 95% CI, 1.1–43.8; P = .04). The results indicate that high levels of HIV-1 RNA at birth and during primary viremia are associated with early onset of symptoms and rapid disease progression to AIDS and death in perinatally infected children. |
| doi_str_mv | 10.1086/515637 |
| format | Article |
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Richard ; Bryson, Yvonne J.</creator><creatorcontrib>Dickover, Ruth E. ; Dillon, Maryanne ; Leung, Kwan-Moon ; Krogstad, Paul ; Plaeger, Susan ; Kwok, Shirley ; Christopherson, Cindy ; Deveikis, Audra ; Keller, Margaret ; Stiehm, E. Richard ; Bryson, Yvonne J.</creatorcontrib><description>The time of perinatal human immunodeficiency virus type 1 (HIV-1) transmission and the pattern of early plasma viremia as predictors of disease progression were evaluated in infected infants followed from birth. Cox proportional hazards modeling demonstrated that a 1-log higher HIV-1 RNA copy number at birth was associated with a 40% increase in the relative hazard (RH) of developing CDC class A or B symptoms (P = .004), a 60% increase in developing AIDS (P = .01), and an 80% increase in the of risk death (P = .023) over the follow-up period of up to 8 years. the peak HIV-1 RNA copy number for infants during primary viremia was also predictive of progression to AIDS (RH, 9.9; 95% confidence interval [95% CI], 1.8–54.1; P = .008) and death (RH, 6.9; 95% CI, 1.1–43.8; P = .04). The results indicate that high levels of HIV-1 RNA at birth and during primary viremia are associated with early onset of symptoms and rapid disease progression to AIDS and death in perinatally infected children.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/515637</identifier><identifier>PMID: 9697717</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - physiopathology ; Acquired Immunodeficiency Syndrome - virology ; Age of Onset ; AIDS ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Disease progression ; DNA ; Follow-Up Studies ; HIV ; HIV 1 ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infants ; Infections ; Infectious diseases ; Longitudinal Studies ; Major Articles ; Medical sciences ; Polymerase chain reaction ; Prognosis ; Prospective Studies ; Reverse Transcriptase Inhibitors - therapeutic use ; RNA ; RNA, Viral - blood ; Symptoms ; Time Factors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Zidovudine - therapeutic use</subject><ispartof>The Journal of infectious diseases, 1998-08, Vol.178 (2), p.375-387</ispartof><rights>Copyright 1998 Infectious Diseases Society of America</rights><rights>1998 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Aug 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-c00b437f3039539ada5987abb0957fbbda9c57cd191d73b934592ac9b3909ebc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30119552$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30119552$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,27931,27932,58024,58257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2342357$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9697717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dickover, Ruth E.</creatorcontrib><creatorcontrib>Dillon, Maryanne</creatorcontrib><creatorcontrib>Leung, Kwan-Moon</creatorcontrib><creatorcontrib>Krogstad, Paul</creatorcontrib><creatorcontrib>Plaeger, Susan</creatorcontrib><creatorcontrib>Kwok, Shirley</creatorcontrib><creatorcontrib>Christopherson, Cindy</creatorcontrib><creatorcontrib>Deveikis, Audra</creatorcontrib><creatorcontrib>Keller, Margaret</creatorcontrib><creatorcontrib>Stiehm, E. Richard</creatorcontrib><creatorcontrib>Bryson, Yvonne J.</creatorcontrib><title>Early Prognostic Indicators in Primary Perinatal Human Immunodeficiency Virus Type 1 Infection: Importance of Viral RNA and the Timing of Transmission on Long-Term Outcome</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The time of perinatal human immunodeficiency virus type 1 (HIV-1) transmission and the pattern of early plasma viremia as predictors of disease progression were evaluated in infected infants followed from birth. Cox proportional hazards modeling demonstrated that a 1-log higher HIV-1 RNA copy number at birth was associated with a 40% increase in the relative hazard (RH) of developing CDC class A or B symptoms (P = .004), a 60% increase in developing AIDS (P = .01), and an 80% increase in the of risk death (P = .023) over the follow-up period of up to 8 years. the peak HIV-1 RNA copy number for infants during primary viremia was also predictive of progression to AIDS (RH, 9.9; 95% confidence interval [95% CI], 1.8–54.1; P = .008) and death (RH, 6.9; 95% CI, 1.1–43.8; P = .04). The results indicate that high levels of HIV-1 RNA at birth and during primary viremia are associated with early onset of symptoms and rapid disease progression to AIDS and death in perinatally infected children.</description><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Age of Onset</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease progression</subject><subject>DNA</subject><subject>Follow-Up Studies</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Reverse Transcriptase Inhibitors - therapeutic use</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>Symptoms</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Zidovudine - therapeutic use</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqHCEYRqU0pJu0fYOClJK7SXUcdexdCEl2YduEMg2lN-I4ztbtjG7Vgewz9SXrssu29KYgeHGOn_p_ALzG6BKjmr2nmDLCn4EZpoQXjGHyHMwQKssC10K8AGcxrhFCFWH8FJwKJjjHfAZ-3agwbOFD8CvnY7IaLlxntUo-RGhdBnZUIQsmWKeSGuB8GpWDi3GcnO9Mb7U1Tm_how1ThM12YyDOGb3RyXr3IYsbH5Jy2kDf76wc8fnTFVSug-m7gY0drVvtWBOUi6ONMZ-DeS29WxWNCSO8n5L2o3kJTno1RPPqsJ-DL7c3zfW8WN7fLa6vloUmNU2FRqitCO8JIoISoTpFRc1V2yJBed-2nRKact1hgTtOWkEqKkqlRUsEEqbV5Bxc7HM3wf-cTEwyv0qbYVDO-CnKGiFKGeX_FTHHVHDBsvj2H3Htp-DyJ2RZ7q7N2p80HXyMwfRysx--xEjuOpb7jrP45pA2taPpjtqh1MzfHbiKWg19nqu28aiVpCoJ_StmHXPbR0wQxoLSMvNiz21M5unIVfghGSecyvnXb_Lx4wO5ExWTc_IbQdbG-A</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Dickover, Ruth E.</creator><creator>Dillon, Maryanne</creator><creator>Leung, Kwan-Moon</creator><creator>Krogstad, Paul</creator><creator>Plaeger, Susan</creator><creator>Kwok, Shirley</creator><creator>Christopherson, Cindy</creator><creator>Deveikis, Audra</creator><creator>Keller, Margaret</creator><creator>Stiehm, E. Richard</creator><creator>Bryson, Yvonne J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Early Prognostic Indicators in Primary Perinatal Human Immunodeficiency Virus Type 1 Infection: Importance of Viral RNA and the Timing of Transmission on Long-Term Outcome</title><author>Dickover, Ruth E. ; Dillon, Maryanne ; Leung, Kwan-Moon ; Krogstad, Paul ; Plaeger, Susan ; Kwok, Shirley ; Christopherson, Cindy ; Deveikis, Audra ; Keller, Margaret ; Stiehm, E. Richard ; Bryson, Yvonne J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-c00b437f3039539ada5987abb0957fbbda9c57cd191d73b934592ac9b3909ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>Age of Onset</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease progression</topic><topic>DNA</topic><topic>Follow-Up Studies</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Longitudinal Studies</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Reverse Transcriptase Inhibitors - therapeutic use</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>Symptoms</topic><topic>Time Factors</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Zidovudine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dickover, Ruth E.</creatorcontrib><creatorcontrib>Dillon, Maryanne</creatorcontrib><creatorcontrib>Leung, Kwan-Moon</creatorcontrib><creatorcontrib>Krogstad, Paul</creatorcontrib><creatorcontrib>Plaeger, Susan</creatorcontrib><creatorcontrib>Kwok, Shirley</creatorcontrib><creatorcontrib>Christopherson, Cindy</creatorcontrib><creatorcontrib>Deveikis, Audra</creatorcontrib><creatorcontrib>Keller, Margaret</creatorcontrib><creatorcontrib>Stiehm, E. 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Richard</au><au>Bryson, Yvonne J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Prognostic Indicators in Primary Perinatal Human Immunodeficiency Virus Type 1 Infection: Importance of Viral RNA and the Timing of Transmission on Long-Term Outcome</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>178</volume><issue>2</issue><spage>375</spage><epage>387</epage><pages>375-387</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The time of perinatal human immunodeficiency virus type 1 (HIV-1) transmission and the pattern of early plasma viremia as predictors of disease progression were evaluated in infected infants followed from birth. Cox proportional hazards modeling demonstrated that a 1-log higher HIV-1 RNA copy number at birth was associated with a 40% increase in the relative hazard (RH) of developing CDC class A or B symptoms (P = .004), a 60% increase in developing AIDS (P = .01), and an 80% increase in the of risk death (P = .023) over the follow-up period of up to 8 years. the peak HIV-1 RNA copy number for infants during primary viremia was also predictive of progression to AIDS (RH, 9.9; 95% confidence interval [95% CI], 1.8–54.1; P = .008) and death (RH, 6.9; 95% CI, 1.1–43.8; P = .04). The results indicate that high levels of HIV-1 RNA at birth and during primary viremia are associated with early onset of symptoms and rapid disease progression to AIDS and death in perinatally infected children.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9697717</pmid><doi>10.1086/515637</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of infectious diseases, 1998-08, Vol.178 (2), p.375-387 |
| issn | 0022-1899 1537-6613 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Acquired Immunodeficiency Syndrome - physiopathology Acquired Immunodeficiency Syndrome - virology Age of Onset AIDS AIDS/HIV Anti-HIV Agents - therapeutic use Biological and medical sciences Child Child, Preschool Disease progression DNA Follow-Up Studies HIV HIV 1 HIV Infections - drug therapy HIV Infections - immunology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infant Infant, Newborn Infants Infections Infectious diseases Longitudinal Studies Major Articles Medical sciences Polymerase chain reaction Prognosis Prospective Studies Reverse Transcriptase Inhibitors - therapeutic use RNA RNA, Viral - blood Symptoms Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Zidovudine - therapeutic use |
| title | Early Prognostic Indicators in Primary Perinatal Human Immunodeficiency Virus Type 1 Infection: Importance of Viral RNA and the Timing of Transmission on Long-Term Outcome |
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