Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA

Protein-DNA recognition is often mediated by a small domain containing a recognizable structural motif, such as the helix-turn-helix or the zinc-finger. These motifs are compact structures that dock against the DNA double helix. Another DNA recognition motif, found in a highly conserved family of eu...

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Veröffentlicht in:	Nature (London) 1990-10, Vol.347 (6293), p.575-578
Hauptverfasser:	WEISS, M. A, ELLENBERGER, T, WOBBE, C. R, LEE, J. P, HARRISON, S. C, STRUHL, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factors Activator protein 1 Amino Acid Sequence Base Sequence Binding Sites Biochemistry Biological and medical sciences Blood Proteins - metabolism Circular Dichroism Conformational dynamics in molecular biology Cyclic AMP Response Element-Binding Protein Deoxyribonucleic acid Dichroism Dimerization Dimers DNA DNA - metabolism DNA-Binding Proteins - metabolism Folding Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Gene expression Genetics Leucine Leucine zipper proteins Leucine Zippers Macromolecular Substances Magnetic Resonance Spectroscopy Molecular biophysics Molecular Sequence Data NMR Nuclear magnetic resonance Peptides Protein Conformation Protein Kinases Proteins Proto-Oncogene Proteins c-jun Recognition Saccharomyces cerevisiae Proteins Science Spectrum analysis Transcription factors Transcription Factors - metabolism Yeast Yeasts
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