A method to measure dual NK1/NK2-antagonist activity in dogs

The major pulmonary effects of tachykinins are produced by activation of both NK1- and NK2-receptors. A variety of animal models have been used to profile activity of the tachykinins, particularly rodents and guinea pigs, but little information exists regarding methods to evaluate NK1- and NK2-recep...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1998-03, Vol.39 (2), p.97-101
Hauptverfasser:	Sherwood, J E, Young, S, Selig, W, Schilling, A, Kreutner, W, Egan, R W, Chapman, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Dogs Male Neurokinin A - pharmacology Piperidines - pharmacology Propofol - pharmacology Receptors, Neurokinin-2 - antagonists & inhibitors Receptors, Tachykinin - agonists Receptors, Tachykinin - antagonists & inhibitors Respiratory System - drug effects Substance P - pharmacology Tachykinins - metabolism
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