Expression of moesin and its associated molecule CD44 in epithelial skin tumors
Moesin, one of the ERM (ezrin; radixin; moesin) family members, is directly associated with the cytoplasmic domain of CD44, which is now thought to be related to the metastatic potential of tumor cells. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and vario...
Gespeichert in:
| Veröffentlicht in: | Journal of cutaneous pathology 1998-05, Vol.25 (5), p.237-243 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 243 |
|---|---|
| container_issue | 5 |
| container_start_page | 237 |
| container_title | Journal of cutaneous pathology |
| container_volume | 25 |
| creator | Ichikawa, Takeshi Masumoto, Junya Kaneko, Miwako Saida, Toshiaki Sagara, Junji Taniguchi, Shun'ichiro |
| description | Moesin, one of the ERM (ezrin; radixin; moesin) family members, is directly associated with the cytoplasmic domain of CD44, which is now thought to be related to the metastatic potential of tumor cells. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and various kinds of epithelial skin tumors: squamous cell carcinoma, verrucous carcinoma, Bowen's disease, solar keratosis, keratoacanthoma, basal cell carcinoma, and extramammary Paget's disease. Normal skin showed positive epidermal staining for moesin with the exception of the stratum corneum. The expression of moesin varied with the type of skin tumor. In basal cell carcinoma, Bowen's disease, and extramammary Paget's disease, moesin expression was either faint or negative. In contrast to Bowen's disease, invasive squamous cell carcinoma showed more intense and heterogeneous staining of the cytoplasm and the cell membrane. Verrucous carcinoma was weakly positive, with a tendency for the moesin to be distributed in the cell membrane. The staining pattern of moesin varied among the different kinds of epithelial skin tumors, and its expression was generally similar to that of the standard form of CD44. These results suggest that moesin is closely inter‐related with CD44 in epithelial skin cells as seen in other cellular systems, and that the variable pattern of moesin staining among the skin tumor cells could reflect expression disorders associated with the transformation. |
| doi_str_mv | 10.1111/j.1600-0560.1998.tb01727.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80050650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80050650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4887-f55fa09a8691041fe9a10af9e6d7997fb157ab0351eb16f92367d1e84d474afb3</originalsourceid><addsrcrecordid>eNqVkF2L1DAUhoMo67j6E4Qi4l3Hk7b58kLQ2XVXWNwVXLwMaXuCmU3b2Z4WZ_-9GabMvbkJyfucN-Fh7B2HNU_r43bNJUAOQqYLY_R6qoGrQq33z9jqFD1nKyihzKXR6iV7RbQF4FJLccbOjDSy0HrFbi_3uxGJwtBng8-6ASn0mevbLEyUOaKhCW7CNiURmzlitrmoqiwxuAvTH4zBxYwe0nmau2Gk1-yFd5HwzbKfs_tvl7821_nN7dX3zZebvKm0VrkXwjswTkvDoeIejePgvEHZKmOUr7lQroZScKy59KYopWo56qqtVOV8XZ6zD8fe3Tg8zkiT7QI1GKPrcZjJagABUkACPx3BZhyIRvR2N4bOjU-Wgz3YtFt7UGYPyuzBpl1s2n0afru8MtcdtqfRRV_K3y-5o8ZFP7q-CXTCikIYI3nCPh-xvyHi0398wG7u74pSpYL8WBBowv2pwI0PVqpSCfv7x5W9uCu-Ssl_2uvyH-dsoAc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80050650</pqid></control><display><type>article</type><title>Expression of moesin and its associated molecule CD44 in epithelial skin tumors</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Ichikawa, Takeshi ; Masumoto, Junya ; Kaneko, Miwako ; Saida, Toshiaki ; Sagara, Junji ; Taniguchi, Shun'ichiro</creator><creatorcontrib>Ichikawa, Takeshi ; Masumoto, Junya ; Kaneko, Miwako ; Saida, Toshiaki ; Sagara, Junji ; Taniguchi, Shun'ichiro</creatorcontrib><description>Moesin, one of the ERM (ezrin; radixin; moesin) family members, is directly associated with the cytoplasmic domain of CD44, which is now thought to be related to the metastatic potential of tumor cells. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and various kinds of epithelial skin tumors: squamous cell carcinoma, verrucous carcinoma, Bowen's disease, solar keratosis, keratoacanthoma, basal cell carcinoma, and extramammary Paget's disease. Normal skin showed positive epidermal staining for moesin with the exception of the stratum corneum. The expression of moesin varied with the type of skin tumor. In basal cell carcinoma, Bowen's disease, and extramammary Paget's disease, moesin expression was either faint or negative. In contrast to Bowen's disease, invasive squamous cell carcinoma showed more intense and heterogeneous staining of the cytoplasm and the cell membrane. Verrucous carcinoma was weakly positive, with a tendency for the moesin to be distributed in the cell membrane. The staining pattern of moesin varied among the different kinds of epithelial skin tumors, and its expression was generally similar to that of the standard form of CD44. These results suggest that moesin is closely inter‐related with CD44 in epithelial skin cells as seen in other cellular systems, and that the variable pattern of moesin staining among the skin tumor cells could reflect expression disorders associated with the transformation.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.1600-0560.1998.tb01727.x</identifier><identifier>PMID: 9696288</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Carcinoma - metabolism ; Carcinoma - pathology ; Dermatology ; Humans ; Hyaluronan Receptors - metabolism ; Immunoenzyme Techniques ; Keratoacanthoma - metabolism ; Keratoacanthoma - pathology ; Keratosis - metabolism ; Keratosis - pathology ; Medical sciences ; Microfilament Proteins ; Neoplasms, Glandular and Epithelial - metabolism ; Neoplasms, Glandular and Epithelial - pathology ; Paget Disease, Extramammary - metabolism ; Paget Disease, Extramammary - pathology ; Proteins - metabolism ; Skin - metabolism ; Skin - pathology ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of cutaneous pathology, 1998-05, Vol.25 (5), p.237-243</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4887-f55fa09a8691041fe9a10af9e6d7997fb157ab0351eb16f92367d1e84d474afb3</citedby><cites>FETCH-LOGICAL-c4887-f55fa09a8691041fe9a10af9e6d7997fb157ab0351eb16f92367d1e84d474afb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0560.1998.tb01727.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0560.1998.tb01727.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2259961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9696288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichikawa, Takeshi</creatorcontrib><creatorcontrib>Masumoto, Junya</creatorcontrib><creatorcontrib>Kaneko, Miwako</creatorcontrib><creatorcontrib>Saida, Toshiaki</creatorcontrib><creatorcontrib>Sagara, Junji</creatorcontrib><creatorcontrib>Taniguchi, Shun'ichiro</creatorcontrib><title>Expression of moesin and its associated molecule CD44 in epithelial skin tumors</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Moesin, one of the ERM (ezrin; radixin; moesin) family members, is directly associated with the cytoplasmic domain of CD44, which is now thought to be related to the metastatic potential of tumor cells. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and various kinds of epithelial skin tumors: squamous cell carcinoma, verrucous carcinoma, Bowen's disease, solar keratosis, keratoacanthoma, basal cell carcinoma, and extramammary Paget's disease. Normal skin showed positive epidermal staining for moesin with the exception of the stratum corneum. The expression of moesin varied with the type of skin tumor. In basal cell carcinoma, Bowen's disease, and extramammary Paget's disease, moesin expression was either faint or negative. In contrast to Bowen's disease, invasive squamous cell carcinoma showed more intense and heterogeneous staining of the cytoplasm and the cell membrane. Verrucous carcinoma was weakly positive, with a tendency for the moesin to be distributed in the cell membrane. The staining pattern of moesin varied among the different kinds of epithelial skin tumors, and its expression was generally similar to that of the standard form of CD44. These results suggest that moesin is closely inter‐related with CD44 in epithelial skin cells as seen in other cellular systems, and that the variable pattern of moesin staining among the skin tumor cells could reflect expression disorders associated with the transformation.</description><subject>Biological and medical sciences</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Immunoenzyme Techniques</subject><subject>Keratoacanthoma - metabolism</subject><subject>Keratoacanthoma - pathology</subject><subject>Keratosis - metabolism</subject><subject>Keratosis - pathology</subject><subject>Medical sciences</subject><subject>Microfilament Proteins</subject><subject>Neoplasms, Glandular and Epithelial - metabolism</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Paget Disease, Extramammary - metabolism</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Proteins - metabolism</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2L1DAUhoMo67j6E4Qi4l3Hk7b58kLQ2XVXWNwVXLwMaXuCmU3b2Z4WZ_-9GabMvbkJyfucN-Fh7B2HNU_r43bNJUAOQqYLY_R6qoGrQq33z9jqFD1nKyihzKXR6iV7RbQF4FJLccbOjDSy0HrFbi_3uxGJwtBng8-6ASn0mevbLEyUOaKhCW7CNiURmzlitrmoqiwxuAvTH4zBxYwe0nmau2Gk1-yFd5HwzbKfs_tvl7821_nN7dX3zZebvKm0VrkXwjswTkvDoeIejePgvEHZKmOUr7lQroZScKy59KYopWo56qqtVOV8XZ6zD8fe3Tg8zkiT7QI1GKPrcZjJagABUkACPx3BZhyIRvR2N4bOjU-Wgz3YtFt7UGYPyuzBpl1s2n0afru8MtcdtqfRRV_K3y-5o8ZFP7q-CXTCikIYI3nCPh-xvyHi0398wG7u74pSpYL8WBBowv2pwI0PVqpSCfv7x5W9uCu-Ssl_2uvyH-dsoAc</recordid><startdate>199805</startdate><enddate>199805</enddate><creator>Ichikawa, Takeshi</creator><creator>Masumoto, Junya</creator><creator>Kaneko, Miwako</creator><creator>Saida, Toshiaki</creator><creator>Sagara, Junji</creator><creator>Taniguchi, Shun'ichiro</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199805</creationdate><title>Expression of moesin and its associated molecule CD44 in epithelial skin tumors</title><author>Ichikawa, Takeshi ; Masumoto, Junya ; Kaneko, Miwako ; Saida, Toshiaki ; Sagara, Junji ; Taniguchi, Shun'ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4887-f55fa09a8691041fe9a10af9e6d7997fb157ab0351eb16f92367d1e84d474afb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Immunoenzyme Techniques</topic><topic>Keratoacanthoma - metabolism</topic><topic>Keratoacanthoma - pathology</topic><topic>Keratosis - metabolism</topic><topic>Keratosis - pathology</topic><topic>Medical sciences</topic><topic>Microfilament Proteins</topic><topic>Neoplasms, Glandular and Epithelial - metabolism</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Paget Disease, Extramammary - metabolism</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Proteins - metabolism</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikawa, Takeshi</creatorcontrib><creatorcontrib>Masumoto, Junya</creatorcontrib><creatorcontrib>Kaneko, Miwako</creatorcontrib><creatorcontrib>Saida, Toshiaki</creatorcontrib><creatorcontrib>Sagara, Junji</creatorcontrib><creatorcontrib>Taniguchi, Shun'ichiro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikawa, Takeshi</au><au>Masumoto, Junya</au><au>Kaneko, Miwako</au><au>Saida, Toshiaki</au><au>Sagara, Junji</au><au>Taniguchi, Shun'ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of moesin and its associated molecule CD44 in epithelial skin tumors</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>1998-05</date><risdate>1998</risdate><volume>25</volume><issue>5</issue><spage>237</spage><epage>243</epage><pages>237-243</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>Moesin, one of the ERM (ezrin; radixin; moesin) family members, is directly associated with the cytoplasmic domain of CD44, which is now thought to be related to the metastatic potential of tumor cells. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and various kinds of epithelial skin tumors: squamous cell carcinoma, verrucous carcinoma, Bowen's disease, solar keratosis, keratoacanthoma, basal cell carcinoma, and extramammary Paget's disease. Normal skin showed positive epidermal staining for moesin with the exception of the stratum corneum. The expression of moesin varied with the type of skin tumor. In basal cell carcinoma, Bowen's disease, and extramammary Paget's disease, moesin expression was either faint or negative. In contrast to Bowen's disease, invasive squamous cell carcinoma showed more intense and heterogeneous staining of the cytoplasm and the cell membrane. Verrucous carcinoma was weakly positive, with a tendency for the moesin to be distributed in the cell membrane. The staining pattern of moesin varied among the different kinds of epithelial skin tumors, and its expression was generally similar to that of the standard form of CD44. These results suggest that moesin is closely inter‐related with CD44 in epithelial skin cells as seen in other cellular systems, and that the variable pattern of moesin staining among the skin tumor cells could reflect expression disorders associated with the transformation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9696288</pmid><doi>10.1111/j.1600-0560.1998.tb01727.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6987 |
| ispartof | Journal of cutaneous pathology, 1998-05, Vol.25 (5), p.237-243 |
| issn | 0303-6987 1600-0560 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80050650 |
| source | MEDLINE; Wiley Journals |
| subjects | Biological and medical sciences Carcinoma - metabolism Carcinoma - pathology Dermatology Humans Hyaluronan Receptors - metabolism Immunoenzyme Techniques Keratoacanthoma - metabolism Keratoacanthoma - pathology Keratosis - metabolism Keratosis - pathology Medical sciences Microfilament Proteins Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Paget Disease, Extramammary - metabolism Paget Disease, Extramammary - pathology Proteins - metabolism Skin - metabolism Skin - pathology Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Expression of moesin and its associated molecule CD44 in epithelial skin tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T16%3A50%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20moesin%20and%20its%20associated%20molecule%20CD44%20in%20epithelial%20skin%20tumors&rft.jtitle=Journal%20of%20cutaneous%20pathology&rft.au=Ichikawa,%20Takeshi&rft.date=1998-05&rft.volume=25&rft.issue=5&rft.spage=237&rft.epage=243&rft.pages=237-243&rft.issn=0303-6987&rft.eissn=1600-0560&rft.coden=JCUPBN&rft_id=info:doi/10.1111/j.1600-0560.1998.tb01727.x&rft_dat=%3Cproquest_cross%3E80050650%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80050650&rft_id=info:pmid/9696288&rfr_iscdi=true |