Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population
von Willebrand factor (vWF) is a large glycoprotein secreted predominantly by endothelial cells in both the systemic and pulmonary circulations and has a central role in the formation of the platelet plug. It has been put forward as a possible marker of endothelial cell injury, but is not ideal in t...
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| Veröffentlicht in: | Respiratory medicine 1998-03, Vol.92 (3), p.395-400 |
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| creator | Boldy, D.A.R. Short, P.E. Cowen, P. Hill, F.G.H. Chambers, D.C. Ayres, J.G. |
| description | von Willebrand factor (vWF) is a large glycoprotein secreted predominantly by endothelial cells in both the systemic and pulmonary circulations and has a central role in the formation of the platelet plug. It has been put forward as a possible marker of endothelial cell injury, but is not ideal in that it is not specific for either the pulmonary or systemic circulation and may be released as part of the acute phase response from otherwise healthy endothelial cells.
We undertook two studies (i) to assess within-subject variation in plasma von Willebrand factor antigen (vWF:Ag) levels over time and to assess between-subject variation in a healthy patient population, and (ii) as part of a descriptive study of acute bronchitis, to assess whether plasma vWF:Ag levels altered in such a common and minor insult.
A random sample of patients aged 45–74 years were taken from a local general practice. vWF:Ag levels were measured on three occasions, and spirometry was performed. The descriptive study was undertaken on patients in the general practice diagnosed with acute bronchitis without pre-existing pulmonary disease. Plasma vWF:Ag was measured on presentation and 14 and 42 days later.
In 219 randomly selected patients the mean plasma vWF:Ag was similar at all three visits, the within-subject standard deviation being 0·09 U ml
−1. vWF:Ag levels rose significantly with age (
r
2=0·29,
P |
| doi_str_mv | 10.1016/S0954-6111(98)90281-5 |
| format | Article |
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We undertook two studies (i) to assess within-subject variation in plasma von Willebrand factor antigen (vWF:Ag) levels over time and to assess between-subject variation in a healthy patient population, and (ii) as part of a descriptive study of acute bronchitis, to assess whether plasma vWF:Ag levels altered in such a common and minor insult.
A random sample of patients aged 45–74 years were taken from a local general practice. vWF:Ag levels were measured on three occasions, and spirometry was performed. The descriptive study was undertaken on patients in the general practice diagnosed with acute bronchitis without pre-existing pulmonary disease. Plasma vWF:Ag was measured on presentation and 14 and 42 days later.
In 219 randomly selected patients the mean plasma vWF:Ag was similar at all three visits, the within-subject standard deviation being 0·09 U ml
−1. vWF:Ag levels rose significantly with age (
r
2=0·29,
P<0·01). In 39 patients with acute bronchitis, the plasma vWF:Ag level at presentation (1·51 U ml
−1) was significantly higher than at 2 and 6 weeks later (1·06 U ml
−1 and 1·12 U ml
−1 respectively). There was no correlation between plasma vWF:Ag and C-reactive protein on presentation.
We conclude that there is relatively little variation in an individual's plasma vWF:Ag level but that levels increase significantly with age. The observed elevation occurring with acute bronchitis is a true phenomenon; the absence of an associated acute phase response suggests that endothelial cell injury is the mechanism for the rise. These observations are important in the context of vWF as a marker of endothelial cell damage, as a common and supposedly minor insult such as acute bronchitis may markedly raise plasma levels.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/S0954-6111(98)90281-5</identifier><identifier>PMID: 9692095</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acute Disease ; Age Factors ; Aged ; Antigens - blood ; Biological and medical sciences ; Bronchitis - blood ; Bronchitis - epidemiology ; Bronchitis - physiopathology ; England - epidemiology ; Female ; Forced Expiratory Volume ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Respiratory system ; Vital Capacity ; von Willebrand Factor - immunology</subject><ispartof>Respiratory medicine, 1998-03, Vol.92 (3), p.395-400</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-a9d6cfab9f9a1283962d55bc58439bd704c8621d91672e9d06e81db60b8134c93</citedby><cites>FETCH-LOGICAL-c502t-a9d6cfab9f9a1283962d55bc58439bd704c8621d91672e9d06e81db60b8134c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611198902815$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2219199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9692095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boldy, D.A.R.</creatorcontrib><creatorcontrib>Short, P.E.</creatorcontrib><creatorcontrib>Cowen, P.</creatorcontrib><creatorcontrib>Hill, F.G.H.</creatorcontrib><creatorcontrib>Chambers, D.C.</creatorcontrib><creatorcontrib>Ayres, J.G.</creatorcontrib><title>Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>von Willebrand factor (vWF) is a large glycoprotein secreted predominantly by endothelial cells in both the systemic and pulmonary circulations and has a central role in the formation of the platelet plug. It has been put forward as a possible marker of endothelial cell injury, but is not ideal in that it is not specific for either the pulmonary or systemic circulation and may be released as part of the acute phase response from otherwise healthy endothelial cells.
We undertook two studies (i) to assess within-subject variation in plasma von Willebrand factor antigen (vWF:Ag) levels over time and to assess between-subject variation in a healthy patient population, and (ii) as part of a descriptive study of acute bronchitis, to assess whether plasma vWF:Ag levels altered in such a common and minor insult.
A random sample of patients aged 45–74 years were taken from a local general practice. vWF:Ag levels were measured on three occasions, and spirometry was performed. The descriptive study was undertaken on patients in the general practice diagnosed with acute bronchitis without pre-existing pulmonary disease. Plasma vWF:Ag was measured on presentation and 14 and 42 days later.
In 219 randomly selected patients the mean plasma vWF:Ag was similar at all three visits, the within-subject standard deviation being 0·09 U ml
−1. vWF:Ag levels rose significantly with age (
r
2=0·29,
P<0·01). In 39 patients with acute bronchitis, the plasma vWF:Ag level at presentation (1·51 U ml
−1) was significantly higher than at 2 and 6 weeks later (1·06 U ml
−1 and 1·12 U ml
−1 respectively). There was no correlation between plasma vWF:Ag and C-reactive protein on presentation.
We conclude that there is relatively little variation in an individual's plasma vWF:Ag level but that levels increase significantly with age. The observed elevation occurring with acute bronchitis is a true phenomenon; the absence of an associated acute phase response suggests that endothelial cell injury is the mechanism for the rise. These observations are important in the context of vWF as a marker of endothelial cell damage, as a common and supposedly minor insult such as acute bronchitis may markedly raise plasma levels.</description><subject>Acute Disease</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Antigens - blood</subject><subject>Biological and medical sciences</subject><subject>Bronchitis - blood</subject><subject>Bronchitis - epidemiology</subject><subject>Bronchitis - physiopathology</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Respiratory system</subject><subject>Vital Capacity</subject><subject>von Willebrand Factor - immunology</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67j6ExZyENFDa5JOsqmTyOIXLCioeJKQTqo1kk7GpHvAf2_3zjBXTwX1PvXBQ8gVZy854_rVFwZKdppz_hzMC2DC8E7dIzuuetH1TMv7ZHdGHpJHrf1mjIGU7IJcgAaxhjvy43NybXI04QFTo2Wkh5Lp95gSDtXlQEfn51Kpy3P8iZnGTJ1fZqRDLdn_inNsdMO2Ps2lTi7Rfdkvyc2x5MfkwehSwyenekm-vXv79eZDd_vp_cebN7edV0zMnYOg_egGGMFxYXrQIig1eGVkD0O4ZtIbLXgArq8FQmAaDQ-DZoPhvfTQX5Jnx737Wv4s2GY7xeYxJZexLM0axhSTQq6gOoK-ltYqjnZf4-TqX8uZ3bTaO612c2bB2DutVq1zV6cDyzBhOE-dPK7501PumndpXNX52M6YEBw4bH--PmKrazxErLb5iNljiBX9bEOJ_3nkHw_Hk_I</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Boldy, D.A.R.</creator><creator>Short, P.E.</creator><creator>Cowen, P.</creator><creator>Hill, F.G.H.</creator><creator>Chambers, D.C.</creator><creator>Ayres, J.G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population</title><author>Boldy, D.A.R. ; Short, P.E. ; Cowen, P. ; Hill, F.G.H. ; Chambers, D.C. ; Ayres, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-a9d6cfab9f9a1283962d55bc58439bd704c8621d91672e9d06e81db60b8134c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acute Disease</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Antigens - blood</topic><topic>Biological and medical sciences</topic><topic>Bronchitis - blood</topic><topic>Bronchitis - epidemiology</topic><topic>Bronchitis - physiopathology</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Respiratory system</topic><topic>Vital Capacity</topic><topic>von Willebrand Factor - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boldy, D.A.R.</creatorcontrib><creatorcontrib>Short, P.E.</creatorcontrib><creatorcontrib>Cowen, P.</creatorcontrib><creatorcontrib>Hill, F.G.H.</creatorcontrib><creatorcontrib>Chambers, D.C.</creatorcontrib><creatorcontrib>Ayres, J.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boldy, D.A.R.</au><au>Short, P.E.</au><au>Cowen, P.</au><au>Hill, F.G.H.</au><au>Chambers, D.C.</au><au>Ayres, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>92</volume><issue>3</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>von Willebrand factor (vWF) is a large glycoprotein secreted predominantly by endothelial cells in both the systemic and pulmonary circulations and has a central role in the formation of the platelet plug. It has been put forward as a possible marker of endothelial cell injury, but is not ideal in that it is not specific for either the pulmonary or systemic circulation and may be released as part of the acute phase response from otherwise healthy endothelial cells.
We undertook two studies (i) to assess within-subject variation in plasma von Willebrand factor antigen (vWF:Ag) levels over time and to assess between-subject variation in a healthy patient population, and (ii) as part of a descriptive study of acute bronchitis, to assess whether plasma vWF:Ag levels altered in such a common and minor insult.
A random sample of patients aged 45–74 years were taken from a local general practice. vWF:Ag levels were measured on three occasions, and spirometry was performed. The descriptive study was undertaken on patients in the general practice diagnosed with acute bronchitis without pre-existing pulmonary disease. Plasma vWF:Ag was measured on presentation and 14 and 42 days later.
In 219 randomly selected patients the mean plasma vWF:Ag was similar at all three visits, the within-subject standard deviation being 0·09 U ml
−1. vWF:Ag levels rose significantly with age (
r
2=0·29,
P<0·01). In 39 patients with acute bronchitis, the plasma vWF:Ag level at presentation (1·51 U ml
−1) was significantly higher than at 2 and 6 weeks later (1·06 U ml
−1 and 1·12 U ml
−1 respectively). There was no correlation between plasma vWF:Ag and C-reactive protein on presentation.
We conclude that there is relatively little variation in an individual's plasma vWF:Ag level but that levels increase significantly with age. The observed elevation occurring with acute bronchitis is a true phenomenon; the absence of an associated acute phase response suggests that endothelial cell injury is the mechanism for the rise. These observations are important in the context of vWF as a marker of endothelial cell damage, as a common and supposedly minor insult such as acute bronchitis may markedly raise plasma levels.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9692095</pmid><doi>10.1016/S0954-6111(98)90281-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Respiratory medicine, 1998-03, Vol.92 (3), p.395-400 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Age Factors Aged Antigens - blood Biological and medical sciences Bronchitis - blood Bronchitis - epidemiology Bronchitis - physiopathology England - epidemiology Female Forced Expiratory Volume Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Respiratory system Vital Capacity von Willebrand Factor - immunology |
| title | Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population |
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