Temporal and kinetic determinants of the inhibition of LDL oxidation by N-acetylcysteine (NAC)
We investigated the ability of NAC to inhibit in vitro LDL oxidation, and the effects of the timing of NAC addition, repeated additions of NAC, and the presence of preoxidized LDL, on the oxidation reaction. NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2′-azobis(2-amidinopropane...
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| Veröffentlicht in: | Atherosclerosis 1998-06, Vol.138 (2), p.319-327 |
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| container_title | Atherosclerosis |
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| creator | Rattan, Anil K. Arad, Yadon |
| description | We investigated the ability of NAC to inhibit in vitro LDL oxidation, and the effects of the timing of NAC addition, repeated additions of NAC, and the presence of preoxidized LDL, on the oxidation reaction. NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2′-azobis(2-amidinopropane) dihydrochloride, and UV light, and protected LDL against depletion of antioxidant vitamins. Glutathione was similarly effective against copper-mediated LDL oxidation. NAC's effectiveness was inversely related to the timing of its addition. Sequential NAC additions prolonged the lag phase more effectively than initial addition of the same total dose. NAC reduced CD formation during the oxidation of native LDL by oxidized LDL. NAC's effectiveness as an inhibitor of in vitro LDL oxidation is dependent on the temporal sequence of the oxidation reaction, sequential additions, and the presence of previously oxidized LDL. |
| doi_str_mv | 10.1016/S0021-9150(98)00041-0 |
| format | Article |
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NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2′-azobis(2-amidinopropane) dihydrochloride, and UV light, and protected LDL against depletion of antioxidant vitamins. Glutathione was similarly effective against copper-mediated LDL oxidation. NAC's effectiveness was inversely related to the timing of its addition. Sequential NAC additions prolonged the lag phase more effectively than initial addition of the same total dose. NAC reduced CD formation during the oxidation of native LDL by oxidized LDL. NAC's effectiveness as an inhibitor of in vitro LDL oxidation is dependent on the temporal sequence of the oxidation reaction, sequential additions, and the presence of previously oxidized LDL.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(98)00041-0</identifier><identifier>PMID: 9690915</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Acetylcysteine - metabolism ; Acetylcysteine - pharmacology ; Atherosclerosis ; Biological and medical sciences ; Free Radical Scavengers - metabolism ; Free Radical Scavengers - pharmacology ; Humans ; Kinetics ; LDL ; Lipid Peroxidation - drug effects ; Lipoproteins, LDL - metabolism ; Medical sciences ; Oxidation ; Oxidation-Reduction ; Pharmacology. 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NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2′-azobis(2-amidinopropane) dihydrochloride, and UV light, and protected LDL against depletion of antioxidant vitamins. Glutathione was similarly effective against copper-mediated LDL oxidation. NAC's effectiveness was inversely related to the timing of its addition. Sequential NAC additions prolonged the lag phase more effectively than initial addition of the same total dose. NAC reduced CD formation during the oxidation of native LDL by oxidized LDL. NAC's effectiveness as an inhibitor of in vitro LDL oxidation is dependent on the temporal sequence of the oxidation reaction, sequential additions, and the presence of previously oxidized LDL.</description><subject>Acetylcysteine - metabolism</subject><subject>Acetylcysteine - pharmacology</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>LDL</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Medical sciences</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiratory system</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qFWyhPwHJB1TBIcVOnMQ-VWihH9IKDtBrrYk9EYbE2dpe1P33eD-0V0623nlmxn4IOePsG2e8uXpgrOSF4jW7UPKSMSZ4wT6QGZetKriQ4iOZHZBj8jnG5w3UcnlEjlSjWM5n5O8jjsspwEDBW_riPCZnqMWEYXQefIp06ml6Qur8k-tccpPfJIubBZ3-OwvboFvTuwIMpvVg1jFhHkMv7q7nl6fkUw9DxC_784T8-XH7OP9VLO5__p5fLwoj6joV3DYGKokK267ppWCc97Yzbb6xVhlr-kYC66FEBUJYXlkGXQ0MbImlraA6IV93c5dh-rfCmPToosFhAI_TKmqZfy7rWmSw3oEmTDEG7PUyuBHCWnOmN1711qveSNNK6q1XzXLf2X7BqhvRHrr2InP9fF-HaGDoA3jj4gErq7IUlczY9x2GWcarw6CjcegNWhfQJG0n985D3gC5mJR4</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Rattan, Anil K.</creator><creator>Arad, Yadon</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Temporal and kinetic determinants of the inhibition of LDL oxidation by N-acetylcysteine (NAC)</title><author>Rattan, Anil K. ; Arad, Yadon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-1d6ca38e9e7b6f84011fdbc7840079cdcf68a0fa2e9a44d13d0ab5a0ad2e2d3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylcysteine - metabolism</topic><topic>Acetylcysteine - pharmacology</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>LDL</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Medical sciences</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rattan, Anil K.</creatorcontrib><creatorcontrib>Arad, Yadon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rattan, Anil K.</au><au>Arad, Yadon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal and kinetic determinants of the inhibition of LDL oxidation by N-acetylcysteine (NAC)</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>138</volume><issue>2</issue><spage>319</spage><epage>327</epage><pages>319-327</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>We investigated the ability of NAC to inhibit in vitro LDL oxidation, and the effects of the timing of NAC addition, repeated additions of NAC, and the presence of preoxidized LDL, on the oxidation reaction. NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2′-azobis(2-amidinopropane) dihydrochloride, and UV light, and protected LDL against depletion of antioxidant vitamins. Glutathione was similarly effective against copper-mediated LDL oxidation. NAC's effectiveness was inversely related to the timing of its addition. Sequential NAC additions prolonged the lag phase more effectively than initial addition of the same total dose. NAC reduced CD formation during the oxidation of native LDL by oxidized LDL. NAC's effectiveness as an inhibitor of in vitro LDL oxidation is dependent on the temporal sequence of the oxidation reaction, sequential additions, and the presence of previously oxidized LDL.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9690915</pmid><doi>10.1016/S0021-9150(98)00041-0</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 1998-06, Vol.138 (2), p.319-327 |
| issn | 0021-9150 1879-1484 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcysteine - metabolism Acetylcysteine - pharmacology Atherosclerosis Biological and medical sciences Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology Humans Kinetics LDL Lipid Peroxidation - drug effects Lipoproteins, LDL - metabolism Medical sciences Oxidation Oxidation-Reduction Pharmacology. Drug treatments Respiratory system |
| title | Temporal and kinetic determinants of the inhibition of LDL oxidation by N-acetylcysteine (NAC) |
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