Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models
DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limb...
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| Veröffentlicht in: | Neuroreport 1998-07, Vol.9 (10), p.2415-2421 |
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| creator | Doretto, M C Garcia-Cairasco, N Pimenta, N J.G Souza, D A Tatsuo, M A.K.F |
| description | DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures. |
| doi_str_mv | 10.1097/00001756-199807130-00048 |
| format | Article |
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Insights from three experimental epilepsy models</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Doretto, M C ; Garcia-Cairasco, N ; Pimenta, N J.G ; Souza, D A ; Tatsuo, M A.K.F</creator><creatorcontrib>Doretto, M C ; Garcia-Cairasco, N ; Pimenta, N J.G ; Souza, D A ; Tatsuo, M A.K.F</creatorcontrib><description>DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199807130-00048</identifier><identifier>PMID: 9694238</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Acoustic Stimulation ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anticonvulsants - pharmacology ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Behavior, Animal - drug effects ; Biological and medical sciences ; Dipyrone - pharmacology ; Electroshock ; Female ; Kindling, Neurologic ; Medical sciences ; Neuropharmacology ; Pain Measurement - drug effects ; Pharmacology. Drug treatments ; Postural Balance - drug effects ; Rats ; Rats, Wistar ; Reflex - drug effects ; Seizures - genetics ; Seizures - prevention & control</subject><ispartof>Neuroreport, 1998-07, Vol.9 (10), p.2415-2421</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4158-1a2760dd21fa5ccc09d6dc0b749a5da1aa4a145e16ec1d7888adc95d7ae08a623</citedby><cites>FETCH-LOGICAL-c4158-1a2760dd21fa5ccc09d6dc0b749a5da1aa4a145e16ec1d7888adc95d7ae08a623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2339172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9694238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doretto, M C</creatorcontrib><creatorcontrib>Garcia-Cairasco, N</creatorcontrib><creatorcontrib>Pimenta, N J.G</creatorcontrib><creatorcontrib>Souza, D A</creatorcontrib><creatorcontrib>Tatsuo, M A.K.F</creatorcontrib><title>Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dipyrone - pharmacology</subject><subject>Electroshock</subject><subject>Female</subject><subject>Kindling, Neurologic</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Postural Balance - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reflex - drug effects</subject><subject>Seizures - genetics</subject><subject>Seizures - prevention & control</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJyD5gDgRsBN_nhAqBSpV4gJSb9bUnnQDThzspGX_fV122RvCF1t-nxlrHhNCOXvLmdXvWF1cS9Vwaw3TvGNNvRHmEdlwobtGSnP1mGyYlbYRVsmn5FkpPypiGTcn5MQqK9rObMjVx2He5TThGwp0SrcYKUzL4NN0u8ZSjxRucFre04upDDfbpdA-p5Eu24xI8feMeRhrDpHiPEScy46OKWAsz8mTHmLBF4f9lHz_dP7t7Etz-fXzxdmHy8YLLk3DodWKhdDyHqT3ntmggmfXWliQATiAAC4kcoWeB22MgeCtDBqQGVBtd0pe7_vOOf1asSxuHIrHGGHCtBZnqhbNlP0vyJUUgjNRQbMHfU6lZOzdXIeEvHOcuQf77q99d7Tv_tivpS8Pb6zXI4Zj4UF3zV8dcigeYp9h8kM5Ym3XWa4fZhJ77C7FBXP5Gdc7zG6LEJet-9ffd_dKs52Y</recordid><startdate>19980713</startdate><enddate>19980713</enddate><creator>Doretto, M C</creator><creator>Garcia-Cairasco, N</creator><creator>Pimenta, N J.G</creator><creator>Souza, D A</creator><creator>Tatsuo, M A.K.F</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980713</creationdate><title>Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models</title><author>Doretto, M C ; Garcia-Cairasco, N ; Pimenta, N J.G ; Souza, D A ; Tatsuo, M A.K.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4158-1a2760dd21fa5ccc09d6dc0b749a5da1aa4a145e16ec1d7888adc95d7ae08a623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Dipyrone - pharmacology</topic><topic>Electroshock</topic><topic>Female</topic><topic>Kindling, Neurologic</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Postural Balance - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reflex - drug effects</topic><topic>Seizures - genetics</topic><topic>Seizures - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doretto, M C</creatorcontrib><creatorcontrib>Garcia-Cairasco, N</creatorcontrib><creatorcontrib>Pimenta, N J.G</creatorcontrib><creatorcontrib>Souza, D A</creatorcontrib><creatorcontrib>Tatsuo, M A.K.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doretto, M C</au><au>Garcia-Cairasco, N</au><au>Pimenta, N J.G</au><au>Souza, D A</au><au>Tatsuo, M A.K.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-07-13</date><risdate>1998</risdate><volume>9</volume><issue>10</issue><spage>2415</spage><epage>2421</epage><pages>2415-2421</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>DIPYRONE, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9694238</pmid><doi>10.1097/00001756-199807130-00048</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neuroreport, 1998-07, Vol.9 (10), p.2415-2421 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Acoustic Stimulation Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Biological and medical sciences Dipyrone - pharmacology Electroshock Female Kindling, Neurologic Medical sciences Neuropharmacology Pain Measurement - drug effects Pharmacology. Drug treatments Postural Balance - drug effects Rats Rats, Wistar Reflex - drug effects Seizures - genetics Seizures - prevention & control |
| title | Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models |
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