Minor Congenital Malformations in Infants of Insulin-Dependent Diabetic Women: Association With Poor Glycemic Control
A prospective study of 171 insulin-dependent diabetic pregnant women was undertaken to establish the relationship of glycemic control with minor congenital malformations. Each live-born infant was assessed systematically by two independent examiners using a standardized checklist. There were 32 infa...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1990-11, Vol.76 (5), p.745-749 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | ROSENN, BARAK MIODOVNIK, MENACHEM St. JOHN DIGNAN, PETER SIDDIQI, TARIQ A. KHOURY, JANE MIMOUNI, FRANCIS |
| description | A prospective study of 171 insulin-dependent diabetic pregnant women was undertaken to establish the relationship of glycemic control with minor congenital malformations. Each live-born infant was assessed systematically by two independent examiners using a standardized checklist. There were 32 infants with minor congenital malformations (18.7%). There were significant differences in mean glycohemoglobin A1 between the group with minor congenital malformations and the group without congenital malformations at 12, 16, and 20 weeks, but not at 8 or 24 weeks. Logistic regression analysis showed that maternal age, race, gravidity, White class, duration of diabetes, maternal vasculopathy, and cigarette smoking were not significant variables correlated with minor congenital malformations. Because glycohemoglobin levels from 12-20 weeks are believed to reflect glycemic control from approximately 6-20 weeks, we conclude that poor glycemic control during late embryogenesis and early fetal development is associated with an increased risk of minor congenital malformations. We speculate that improvement of glycemic control during this period should decrease the risk of minor congenital malformations. (Obstet Gynecol 76:745, 1990) |
| doi_str_mv | 10.1097/00006250-199011000-00003 |
| format | Article |
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Each live-born infant was assessed systematically by two independent examiners using a standardized checklist. There were 32 infants with minor congenital malformations (18.7%). There were significant differences in mean glycohemoglobin A1 between the group with minor congenital malformations and the group without congenital malformations at 12, 16, and 20 weeks, but not at 8 or 24 weeks. Logistic regression analysis showed that maternal age, race, gravidity, White class, duration of diabetes, maternal vasculopathy, and cigarette smoking were not significant variables correlated with minor congenital malformations. Because glycohemoglobin levels from 12-20 weeks are believed to reflect glycemic control from approximately 6-20 weeks, we conclude that poor glycemic control during late embryogenesis and early fetal development is associated with an increased risk of minor congenital malformations. We speculate that improvement of glycemic control during this period should decrease the risk of minor congenital malformations. (Obstet Gynecol 76:745, 1990)</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/00006250-199011000-00003</identifier><identifier>PMID: 2216217</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Biological and medical sciences ; Blood Glucose - analysis ; Congenital Abnormalities - epidemiology ; Congenital Abnormalities - etiology ; Diabetes Mellitus, Type 1 - complications ; Female ; Glycated Hemoglobin A - analysis ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy in Diabetics - complications ; Pregnancy Trimester, First ; Pregnancy. Fetus. Placenta ; Prospective Studies ; Regression Analysis ; Risk Factors</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1990-11, Vol.76 (5), p.745-749</ispartof><rights>1990 The American College of Obstetricians and Gynecologists</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19407755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2216217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSENN, BARAK</creatorcontrib><creatorcontrib>MIODOVNIK, MENACHEM</creatorcontrib><creatorcontrib>St. JOHN DIGNAN, PETER</creatorcontrib><creatorcontrib>SIDDIQI, TARIQ A.</creatorcontrib><creatorcontrib>KHOURY, JANE</creatorcontrib><creatorcontrib>MIMOUNI, FRANCIS</creatorcontrib><title>Minor Congenital Malformations in Infants of Insulin-Dependent Diabetic Women: Association With Poor Glycemic Control</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>A prospective study of 171 insulin-dependent diabetic pregnant women was undertaken to establish the relationship of glycemic control with minor congenital malformations. Each live-born infant was assessed systematically by two independent examiners using a standardized checklist. There were 32 infants with minor congenital malformations (18.7%). There were significant differences in mean glycohemoglobin A1 between the group with minor congenital malformations and the group without congenital malformations at 12, 16, and 20 weeks, but not at 8 or 24 weeks. Logistic regression analysis showed that maternal age, race, gravidity, White class, duration of diabetes, maternal vasculopathy, and cigarette smoking were not significant variables correlated with minor congenital malformations. Because glycohemoglobin levels from 12-20 weeks are believed to reflect glycemic control from approximately 6-20 weeks, we conclude that poor glycemic control during late embryogenesis and early fetal development is associated with an increased risk of minor congenital malformations. We speculate that improvement of glycemic control during this period should decrease the risk of minor congenital malformations. (Obstet Gynecol 76:745, 1990)</description><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Congenital Abnormalities - etiology</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - complications</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PXCEUhklTY0fbn9CETbu7LR_3i-7MaNVE0y5M7I4A99Ch5cIUuDH-e9GZ6ko2cM553vckLwhhSr5QIoavpJ6edaShQhBKa9U8tvgbtKLjwBvG-a-3aEUIE80wtu07dJTzn0rQXvBDdMgY7RkdVmi5diEmvI7hNwRXlMfXytuYZlVcDBm7gC-DVaFkHG195sW70JzCFsIEoeBTpzQUZ_BtnCF8wyc5R-OexPjWlQ3-Gav9ub83MFeq7ikp-vfowCqf4cP-PkY3389u1hfN1Y_zy_XJVWM4J7yZ-o4waoZJWE3aaQKiu6mWrFej7VsteK8NaEtHyugkQJuRtzBYYTTpYOTH6PPOdpvivwVykbPLBrxXAeKS5UhI23MmKjjuQJNizgms3CY3q3QvKZGPgcv_gcvnwJ9avEo_7ncseobpWbhPuM4_7ecqmxptUsG4_OIvWjIMXVe5dsfdRV8g5b9-uYMkN6B82cjX_ps_AEyHmZ0</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>ROSENN, BARAK</creator><creator>MIODOVNIK, MENACHEM</creator><creator>St. JOHN DIGNAN, PETER</creator><creator>SIDDIQI, TARIQ A.</creator><creator>KHOURY, JANE</creator><creator>MIMOUNI, FRANCIS</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199011</creationdate><title>Minor Congenital Malformations in Infants of Insulin-Dependent Diabetic Women: Association With Poor Glycemic Control</title><author>ROSENN, BARAK ; MIODOVNIK, MENACHEM ; St. JOHN DIGNAN, PETER ; SIDDIQI, TARIQ A. ; KHOURY, JANE ; MIMOUNI, FRANCIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3303-d65021c7d9fb04dde0b5dc7d26a8f64b936bcebf18121d9ebc834e7f9cb05e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Congenital Abnormalities - etiology</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - complications</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Fetus. 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Each live-born infant was assessed systematically by two independent examiners using a standardized checklist. There were 32 infants with minor congenital malformations (18.7%). There were significant differences in mean glycohemoglobin A1 between the group with minor congenital malformations and the group without congenital malformations at 12, 16, and 20 weeks, but not at 8 or 24 weeks. Logistic regression analysis showed that maternal age, race, gravidity, White class, duration of diabetes, maternal vasculopathy, and cigarette smoking were not significant variables correlated with minor congenital malformations. Because glycohemoglobin levels from 12-20 weeks are believed to reflect glycemic control from approximately 6-20 weeks, we conclude that poor glycemic control during late embryogenesis and early fetal development is associated with an increased risk of minor congenital malformations. We speculate that improvement of glycemic control during this period should decrease the risk of minor congenital malformations. (Obstet Gynecol 76:745, 1990)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>2216217</pmid><doi>10.1097/00006250-199011000-00003</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Blood Glucose - analysis Congenital Abnormalities - epidemiology Congenital Abnormalities - etiology Diabetes Mellitus, Type 1 - complications Female Glycated Hemoglobin A - analysis Gynecology. Andrology. Obstetrics Humans Infant, Newborn Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy in Diabetics - complications Pregnancy Trimester, First Pregnancy. Fetus. Placenta Prospective Studies Regression Analysis Risk Factors |
| title | Minor Congenital Malformations in Infants of Insulin-Dependent Diabetic Women: Association With Poor Glycemic Control |
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