In vitro evaluation of guar gum as a carrier for colon-specific drug delivery
A novel tablet formulation for oral administration using guar gum as the carrier and indomethacin as a model drug has been investigated for colon-specific drug delivery using in vitro methods. Drug release studies under conditions mimicking mouth to colon transit have shown that guar gum protects th...
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| Veröffentlicht in: | Journal of controlled release 1998-02, Vol.51 (2), p.281-287 |
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| container_title | Journal of controlled release |
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| creator | Prasad, Y.V.Rama Krishnaiah, Y.S.R Satyanarayana, S |
| description | A novel tablet formulation for oral administration using guar gum as the carrier and indomethacin as a model drug has been investigated for colon-specific drug delivery using in vitro methods. Drug release studies under conditions mimicking mouth to colon transit have shown that guar gum protects the drug from being released completely in the physiological environment of stomach and small intestine. Studies in pH 6.8 phosphate buffered saline (PBS) containing rat caecal contents have demonstrated the susceptibility of guar gum to the colonic bacterial enzyme action with consequent drug release. The pre-treatment of rats orally with 1 ml of 2% w/v aqueous dispersion of guar gum for 3 days induced enzymes specifically acting on guar gum thereby increasing drug release. A further increase in drug release was observed with rat caecal contents obtained after 7 days of pre-treatment. The presence of 4% w/v of caecal contents obtained after 3 days and 7 days of enzyme induction showed biphasic drug release curves. The results illustrate the usefulness of guar gum as a potential carrier for colon-specific drug delivery. The study also reveals that the use of 4% w/v of rat caecal contents in PBS, obtained after 7 days of enzyme induction provide the best conditions for in vitro evaluation of guar gum. |
| doi_str_mv | 10.1016/S0168-3659(97)00181-8 |
| format | Article |
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Drug release studies under conditions mimicking mouth to colon transit have shown that guar gum protects the drug from being released completely in the physiological environment of stomach and small intestine. Studies in pH 6.8 phosphate buffered saline (PBS) containing rat caecal contents have demonstrated the susceptibility of guar gum to the colonic bacterial enzyme action with consequent drug release. The pre-treatment of rats orally with 1 ml of 2% w/v aqueous dispersion of guar gum for 3 days induced enzymes specifically acting on guar gum thereby increasing drug release. A further increase in drug release was observed with rat caecal contents obtained after 7 days of pre-treatment. The presence of 4% w/v of caecal contents obtained after 3 days and 7 days of enzyme induction showed biphasic drug release curves. The results illustrate the usefulness of guar gum as a potential carrier for colon-specific drug delivery. The study also reveals that the use of 4% w/v of rat caecal contents in PBS, obtained after 7 days of enzyme induction provide the best conditions for in vitro evaluation of guar gum.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/S0168-3659(97)00181-8</identifier><identifier>PMID: 9685926</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Buffers ; Carrier ; Cecum - metabolism ; Colon - metabolism ; Colon-specific drug delivery ; Delayed-Action Preparations ; Dietary Fiber ; Drug Carriers ; Galactans ; Gastrointestinal Transit - physiology ; General pharmacology ; Guar gum ; Hydrogen-Ion Concentration ; Indomethacin - administration & dosage ; Indomethacin - metabolism ; Intestine, Small - metabolism ; Male ; Mannans ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Plant Gums ; Polysaccharide ; Rat caecal contents ; Rats ; Stomach - metabolism ; Tablets</subject><ispartof>Journal of controlled release, 1998-02, Vol.51 (2), p.281-287</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-fbd73a3f8e48b3053797d844e567abdbd279da2e7c088a70fc9ce48023968ca73</citedby><cites>FETCH-LOGICAL-c439t-fbd73a3f8e48b3053797d844e567abdbd279da2e7c088a70fc9ce48023968ca73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365997001818$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2169288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9685926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasad, Y.V.Rama</creatorcontrib><creatorcontrib>Krishnaiah, Y.S.R</creatorcontrib><creatorcontrib>Satyanarayana, S</creatorcontrib><title>In vitro evaluation of guar gum as a carrier for colon-specific drug delivery</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>A novel tablet formulation for oral administration using guar gum as the carrier and indomethacin as a model drug has been investigated for colon-specific drug delivery using in vitro methods. Drug release studies under conditions mimicking mouth to colon transit have shown that guar gum protects the drug from being released completely in the physiological environment of stomach and small intestine. Studies in pH 6.8 phosphate buffered saline (PBS) containing rat caecal contents have demonstrated the susceptibility of guar gum to the colonic bacterial enzyme action with consequent drug release. The pre-treatment of rats orally with 1 ml of 2% w/v aqueous dispersion of guar gum for 3 days induced enzymes specifically acting on guar gum thereby increasing drug release. A further increase in drug release was observed with rat caecal contents obtained after 7 days of pre-treatment. The presence of 4% w/v of caecal contents obtained after 3 days and 7 days of enzyme induction showed biphasic drug release curves. The results illustrate the usefulness of guar gum as a potential carrier for colon-specific drug delivery. The study also reveals that the use of 4% w/v of rat caecal contents in PBS, obtained after 7 days of enzyme induction provide the best conditions for in vitro evaluation of guar gum.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Buffers</subject><subject>Carrier</subject><subject>Cecum - metabolism</subject><subject>Colon - metabolism</subject><subject>Colon-specific drug delivery</subject><subject>Delayed-Action Preparations</subject><subject>Dietary Fiber</subject><subject>Drug Carriers</subject><subject>Galactans</subject><subject>Gastrointestinal Transit - physiology</subject><subject>General pharmacology</subject><subject>Guar gum</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indomethacin - administration & dosage</subject><subject>Indomethacin - metabolism</subject><subject>Intestine, Small - metabolism</subject><subject>Male</subject><subject>Mannans</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Gums</subject><subject>Polysaccharide</subject><subject>Rat caecal contents</subject><subject>Rats</subject><subject>Stomach - metabolism</subject><subject>Tablets</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LJDEQhoO4jKPuTxByEFkPvaY73Z3kJDKsH-CyB91zqE4qEunpjEn3gP_ezAdz9VJ1qKeqXh5CLkr2u2Rle_OSiyx426hfSlwzVsqykEdkXkrBi1qp5pjMD8gJOU3pnTHW8FrMyEy1slFVOyd_nwa69mMMFNfQTzD6MNDg6NsEMZclhUSBGojRY6QuRGpCH4YirdB45w21cXqjFnu_xvh5Tn446BP-3Pcz8v_-z-visXj-9_C0uHsuTM3VWLjOCg7cSaxlx3MmoYSVdY1NK6Czna2EslChMExKEMwZZTLKKp5zGxD8jFzt7q5i-JgwjXrpk8G-hwHDlLRkrG5UyzPY7EATQ0oRnV5Fv4T4qUumNxr1VqPeONJK6K1GLfPexf7B1C3RHrb23vL8cj-HZKB3EQbj0wGrylZVcnPmdodhlrHOBnUyHgeD1kc0o7bBfxPkC_DFjqk</recordid><startdate>19980212</startdate><enddate>19980212</enddate><creator>Prasad, Y.V.Rama</creator><creator>Krishnaiah, Y.S.R</creator><creator>Satyanarayana, S</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980212</creationdate><title>In vitro evaluation of guar gum as a carrier for colon-specific drug delivery</title><author>Prasad, Y.V.Rama ; Krishnaiah, Y.S.R ; Satyanarayana, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-fbd73a3f8e48b3053797d844e567abdbd279da2e7c088a70fc9ce48023968ca73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Buffers</topic><topic>Carrier</topic><topic>Cecum - metabolism</topic><topic>Colon - metabolism</topic><topic>Colon-specific drug delivery</topic><topic>Delayed-Action Preparations</topic><topic>Dietary Fiber</topic><topic>Drug Carriers</topic><topic>Galactans</topic><topic>Gastrointestinal Transit - physiology</topic><topic>General pharmacology</topic><topic>Guar gum</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indomethacin - administration & dosage</topic><topic>Indomethacin - metabolism</topic><topic>Intestine, Small - metabolism</topic><topic>Male</topic><topic>Mannans</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Gums</topic><topic>Polysaccharide</topic><topic>Rat caecal contents</topic><topic>Rats</topic><topic>Stomach - metabolism</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasad, Y.V.Rama</creatorcontrib><creatorcontrib>Krishnaiah, Y.S.R</creatorcontrib><creatorcontrib>Satyanarayana, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasad, Y.V.Rama</au><au>Krishnaiah, Y.S.R</au><au>Satyanarayana, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of guar gum as a carrier for colon-specific drug delivery</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>1998-02-12</date><risdate>1998</risdate><volume>51</volume><issue>2</issue><spage>281</spage><epage>287</epage><pages>281-287</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>A novel tablet formulation for oral administration using guar gum as the carrier and indomethacin as a model drug has been investigated for colon-specific drug delivery using in vitro methods. Drug release studies under conditions mimicking mouth to colon transit have shown that guar gum protects the drug from being released completely in the physiological environment of stomach and small intestine. Studies in pH 6.8 phosphate buffered saline (PBS) containing rat caecal contents have demonstrated the susceptibility of guar gum to the colonic bacterial enzyme action with consequent drug release. The pre-treatment of rats orally with 1 ml of 2% w/v aqueous dispersion of guar gum for 3 days induced enzymes specifically acting on guar gum thereby increasing drug release. A further increase in drug release was observed with rat caecal contents obtained after 7 days of pre-treatment. The presence of 4% w/v of caecal contents obtained after 3 days and 7 days of enzyme induction showed biphasic drug release curves. The results illustrate the usefulness of guar gum as a potential carrier for colon-specific drug delivery. The study also reveals that the use of 4% w/v of rat caecal contents in PBS, obtained after 7 days of enzyme induction provide the best conditions for in vitro evaluation of guar gum.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9685926</pmid><doi>10.1016/S0168-3659(97)00181-8</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Buffers Carrier Cecum - metabolism Colon - metabolism Colon-specific drug delivery Delayed-Action Preparations Dietary Fiber Drug Carriers Galactans Gastrointestinal Transit - physiology General pharmacology Guar gum Hydrogen-Ion Concentration Indomethacin - administration & dosage Indomethacin - metabolism Intestine, Small - metabolism Male Mannans Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plant Gums Polysaccharide Rat caecal contents Rats Stomach - metabolism Tablets |
| title | In vitro evaluation of guar gum as a carrier for colon-specific drug delivery |
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